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Franziska Blaeschke
Franziska Blaeschke
Postdoctoral Scientist, The Gladstone Institutes/ UCSF
gladstone.ucsf.edu의 이메일 확인됨
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Landscape of stimulation-responsive chromatin across diverse human immune cells
D Calderon, MLT Nguyen, A Mezger, A Kathiria, F Müller, V Nguyen, ...
Nature genetics 51 (10), 1494-1505, 2019
2572019
CRISPR activation and interference screens decode stimulation responses in primary human T cells
R Schmidt, Z Steinhart, M Layeghi, JW Freimer, R Bueno, VQ Nguyen, ...
Science 375 (6580), eabj4008, 2022
1892022
Pooled knockin targeting for genome engineering of cellular immunotherapies
TL Roth, PJ Li, F Blaeschke, JF Nies, R Apathy, C Mowery, R Yu, ...
Cell 181 (3), 728-744. e21, 2020
1832020
T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic …
J Feucht, S Kayser, D Gorodezki, M Hamieh, M Döring, F Blaeschke, ...
Oncotarget 7 (47), 76902, 2016
1772016
Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice …
F Blaeschke, D Stenger, T Kaeuferle, S Willier, R Lotfi, AD Kaiser, ...
Cancer Immunology, Immunotherapy 67, 1053-1066, 2018
1652018
Strategies of adoptive T-cell transfer to treat refractory viral infections post allogeneic stem cell transplantation
T Kaeuferle, R Krauss, F Blaeschke, S Willier, T Feuchtinger
Journal of hematology & oncology 12, 1-10, 2019
1512019
Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering
JR Hamilton, CA Tsuchida, DN Nguyen, BR Shy, ER McGarrigle, ...
Cell reports 35 (9), 2021
1472021
Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR
D Stenger, TA Stief, T Käuferle, S Willier, F Rataj, K Schober, B Vick, ...
Blood, 2020
1402020
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
BR Shy, VS Vykunta, A Ha, A Talbot, TL Roth, DN Nguyen, WG Pfeifer, ...
Nature biotechnology 41 (4), 521-531, 2023
1362023
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
J Carnevale, E Shifrut, N Kale, WA Nyberg, F Blaeschke, YY Chen, Z Li, ...
Nature 609 (7925), 174-182, 2022
1222022
CLEC12A and CD33 co-expression as preferential target on pediatric AML for combinatorial immunotherapy
S Willier, P Rothämel, M Hastreiter, J Wilhelm, D Stenger, F Blaeschke, ...
Blood, 2020
692020
Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)
R Dong, KA Libby, F Blaeschke, W Fuchs, A Marson, RD Vale, X Su
The EMBO Journal 39 (16), e104730, 2020
612020
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
RL Rutishauser, CDT Deguit, J Hiatt, F Blaeschke, TL Roth, L Wang, ...
JCI insight 6 (3), 2021
542021
Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation
M Döring, KM Cabanillas Stanchi, M Queudeville, J Feucht, F Blaeschke, ...
Journal of cancer research and clinical oncology 143, 1281-1292, 2017
502017
Leukemia-induced dysfunctional TIM-3+CD4+ bone marrow T cells increase risk of relapse in pediatric B-precursor ALL patients
F Blaeschke, S Willier, D Stenger, M Lepenies, MA Horstmann, ...
Leukemia 34 (10), 2607-2620, 2020
392020
Human HLA-A* 02: 01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo
F Blaeschke, U Thiel, A Kirschner, M Thiede, RA Rubio, D Schirmer, ...
Oncotarget 7 (28), 43267, 2016
322016
Modular pooled discovery of synthetic knockin sequences to program durable cell therapies
F Blaeschke, YY Chen, R Apathy, B Daniel, AY Chen, PA Chen, K Sandor, ...
Cell 186 (19), 4216-4234. e33, 2023
312023
Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy
F Blaeschke, MC Paul, MU Schuhmann, A Rabsteyn, C Schroeder, ...
Cytotherapy 21 (9), 973-986, 2019
312019
CRISPR-Cas9-mediated glucocorticoid resistance in virus-specific T cells for adoptive T cell therapy posttransplantation
T Kaeuferle, L Deisenberger, L Jablonowski, TA Stief, F Blaeschke, ...
Molecular Therapy 28 (9), 1965-1973, 2020
292020
Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A* 02: 01-specific allorestricted T cell receptor transgenic T cells
U Thiel, SJ Schober, I Einspieler, A Kirschner, M Thiede, D Schirmer, ...
Oncoimmunology 6 (5), e1312239, 2017
282017
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