The pro-and anti-inflammatory properties of the cytokine interleukin-6 J Scheller, A Chalaris, D Schmidt-Arras, S Rose-John Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1813 (5), 878-888, 2011 | 4099 | 2011 |
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer S Grivennikov, E Karin, J Terzic, D Mucida, GY Yu, S Vallabhapurapu, ... Cancer cell 15 (2), 103-113, 2009 | 2557 | 2009 |
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis … R Atreya, J Mudter, S Finotto, J Müllberg, T Jostock, S Wirtz, M Schütz, ... Nature medicine 6 (5), 583-588, 2000 | 1603 | 2000 |
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6 S Rose-John International journal of biological sciences 8 (9), 1237, 2012 | 1260 | 2012 |
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation SM Hurst, TS Wilkinson, RM McLoughlin, S Jones, S Horiuchi, ... Immunity 14 (6), 705-714, 2001 | 1086 | 2001 |
Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia DT Teachey, SF Lacey, PA Shaw, JJ Melenhorst, SL Maude, N Frey, ... Cancer discovery 6 (6), 664-679, 2016 | 1082 | 2016 |
Soluble receptors for cytokines and growth factors: generation and biological function. S Rose-John, PC Heinrich Biochemical Journal 300 (Pt 2), 281, 1994 | 1006 | 1994 |
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer M Lesina, MU Kurkowski, K Ludes, S Rose-John, M Treiber, G Klöppel, ... Cancer cell 19 (4), 456-469, 2011 | 959 | 2011 |
TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling C Becker, MC Fantini, C Schramm, HA Lehr, S Wirtz, A Nikolaev, J Burg, ... Immunity 21 (4), 491-501, 2004 | 950 | 2004 |
IL-6 pathway in the liver: from physiopathology to therapy D Schmidt-Arras, S Rose-John Journal of hepatology 64 (6), 1403-1415, 2016 | 908 | 2016 |
Interleukin-6 family cytokines S Rose-John Cold Spring Harbor perspectives in biology 10 (2), a028415, 2018 | 888 | 2018 |
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer S Rose-John, J Scheller, G Elson, SA Jones Journal of leukocyte biology 80 (2), 227-236, 2006 | 888 | 2006 |
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion C Hundhausen, D Misztela, TA Berkhout, N Broadway, P Saftig, K Reiss, ... Blood 102 (4), 1186-1195, 2003 | 835 | 2003 |
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling SA Jones, J Scheller, S Rose-John The Journal of clinical investigation 121 (9), 3375-3383, 2011 | 832 | 2011 |
Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses T Jostock, J Müllberg, S Özbek, R Atreya, G Blinn, N Voltz, M Fischer, ... European journal of biochemistry 268 (1), 160-167, 2001 | 805 | 2001 |
A switch from white to brown fat increases energy expenditure in cancer-associated cachexia M Petruzzelli, M Schweiger, R Schreiber, R Campos-Olivas, M Tsoli, ... Cell metabolism 20 (3), 433-447, 2014 | 761 | 2014 |
Interleukin-6 and its receptors: a highly regulated and dynamic system J Wolf, S Rose-John, C Garbers Cytokine 70 (1), 11-20, 2014 | 722 | 2014 |
The soluble interleukin‐6 receptor is generated by shedding J Mülberg, H Schooltink, T Stoyan, M Günther, L Graeve, G Buse, ... European journal of immunology 23 (2), 473-480, 1993 | 679 | 1993 |
Transcriptional profiling identifies Id2 function in dendritic cell development C Hacker, RD Kirsch, XS Ju, T Hieronymus, TC Gust, C Kuhl, T Jorgas, ... Nature immunology 4 (4), 380-386, 2003 | 670 | 2003 |
A bioactive designer cytokine for human hematopoietic progenitor cell expansion M Fischer, J Goldschmitt, C Peschel, JPG Brakenhoff, KJ Kallen, ... Nature biotechnology 15 (2), 142-145, 1997 | 623 | 1997 |