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Bridgette Cumming
Bridgette Cumming
Research Associate, Africa Health Research Institute
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S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis
R Gopal, L Monin, D Torres, S Slight, S Mehra, KC McKenna, ...
American journal of respiratory and critical care medicine 188 (9), 1137-1146, 2013
2652013
Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
DA Lamprecht, PM Finin, MA Rahman, BM Cumming, SL Russell, ...
Nature communications 7 (1), 12393, 2016
2302016
Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages
BM Cumming, KW Addicott, JH Adamson, AJC Steyn
Elife 7, e39169, 2018
1932018
Ergothioneine maintains redox and bioenergetic homeostasis essential for drug susceptibility and virulence of Mycobacterium tuberculosis
V Saini, BM Cumming, L Guidry, DA Lamprecht, JH Adamson, VP Reddy, ...
Cell reports 14 (3), 572-585, 2016
1532016
Role of ergothioneine in microbial physiology and pathogenesis
BM Cumming, KC Chinta, VP Reddy, AJC Steyn
Antioxidants & Redox Signaling 28 (6), 431-444, 2018
1102018
Mycobacterial WhiB6 differentially regulates ESX-1 and the Dos regulon to modulate granuloma formation and virulence in zebrafish
Z Chen, Y Hu, BM Cumming, P Lu, L Feng, J Deng, AJC Steyn, S Chen
Cell reports 16 (9), 2512-2524, 2016
892016
Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis
MA Rahman, BM Cumming, KW Addicott, HT Pacl, SL Russell, K Nargan, ...
Proceedings of the National Academy of Sciences 117 (12), 6663-6674, 2020
752020
The physiology and genetics of oxidative stress in mycobacteria
BM Cumming, DA Lamprecht, RM Wells, V Saini, JH Mazorodze, ...
Molecular Genetics of Mycobacteria, 297-322, 2014
482014
Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection
BM Cumming, MA Rahman, DA Lamprecht, KH Rohde, V Saini, ...
PLoS pathogens 13 (5), e1006389, 2017
462017
Comprehensive Examination of the Mouse Lung Metabolome Following Mycobacterium tuberculosis Infection Using a Multiplatform Mass Spectrometry Approach
M Fernández-García, F Rey-Stolle, J Boccard, VP Reddy, A García, ...
Journal of proteome research 19 (5), 2053-2070, 2020
442020
Relevance of the Warburg effect in tuberculosis for host-directed therapy
BM Cumming, HT Pacl, AJC Steyn
Frontiers in cellular and infection microbiology 10, 576596, 2020
362020
Metabolic plasticity of central carbon metabolism protects mycobacteria
BM Cumming, AJC Steyn
Proceedings of the National Academy of Sciences 112 (43), 13135-13136, 2015
272015
RbpA and σB association regulates polyphosphate levels to modulate mycobacterial isoniazid‐tolerance
Z Wang, BM Cumming, C Mao, Y Zhu, P Lu, AJC Steyn, S Chen, Y Hu
Molecular microbiology 108 (6), 627-640, 2018
162018
Evolutionary views of tuberculosis: indoleamine 2, 3‐dioxygenase catalyzed nicotinamide synthesis reflects shifts in macrophage metabolism: indoleamine 2, 3‐dioxygenase …
MS Suchard, CG Adu‐Gyamfi, BM Cumming, DM Savulescu
BioEssays 42 (5), 1900220, 2020
142020
Mycobacterial WhiB6 differentially regulates ESX-1 and the Dos regulon to modulate granuloma formation and virulence in zebrafish. Cell Rep 16: 2512–2524
Z Chen, Y Hu, BM Cumming, P Lu, L Feng, J Deng, AJ Steyn, S Chen
102016
Monocyte phagocytosis of malaria β-haematin in the presence of artemisinin, amodiaquine, chloroquine, doxycycline, primaquine, pyrimethamine and quinine
BM Cumming, JPD Goldring
Experimental parasitology 197, 93-102, 2019
82019
A feedback regulatory loop containing McdR and WhiB2 controls cell division and DNA repair in mycobacteria
W Zhou, S Huang, BM Cumming, Y Zhang, W Tang, AJC Steyn, S Chen, ...
mbio 13 (2), e03343-21, 2022
62022
The Analysis of Mycobacterium tuberculosis-Induced Bioenergetic Changes in Infected Macrophages Using an Extracellular Flux Analyzer
BM Cumming, VP Reddy, AJC Steyn
Immunometabolism: Methods and Protocols, 161-184, 2020
32020
Plasmodium falciparum: effect of antimalarial drugs, malaria pigment (β-haematin) and Plasmodium falciparum lysate on monocyte GTP-cyclohydrolase 1 gene expression
BM Cumming, GMF Watson, JPD Goldring
Experimental parasitology 129 (3), 312-317, 2011
32011
Host bioenergetic parameters reveal cytotoxicity of anti-tuberculosis drugs undetected using conventional viability assays.
BM Cumming, Z Baig, KW Addicott, D Chen, AJ Steyn
Antimicrobial Agents and Chemotherapy. AAC0093221. doi: 10.1128/AAC.00932-21., 2021
22021
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