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Shazia Iqbal, Ph.D
Shazia Iqbal, Ph.D
Trustlife Labs Drug Research & Development Center
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New carbazole linked 1, 2, 3-triazoles as highly potent non-sugar α-glucosidase inhibitors
S Iqbal, MA Khan, K Javaid, R Sadiq, S Fazal-ur-Rehman, MI Choudhary, ...
Bioorganic Chemistry 74, 72-81, 2017
732017
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning
C Zhang, M Shi, W Kim, M Arif, M Klevstig, X Li, H Yang, C Bayram, I Bolat, ...
EBioMedicine 83, 2022
212022
Ellagic acid and its metabolites as potent and selective allosteric inhibitors of liver pyruvate kinase
UM Battisti, C Gao, F Akladios, W Kim, H Yang, C Bayram, I Bolat, ...
Nutrients 15 (3), 577, 2023
142023
Suppression of COX-2/PGE2 levels by carbazole-linked triazoles via modulating methylglyoxal-AGEs and glucose-AGEs–induced ROS/NF-κB signaling in monocytes
H Jahan, NN Siddiqui, S Iqbal, FZ Basha, S Shaikh, M Pizzi, ...
Cellular Signalling 97, 110372, 2022
132022
Chemical constituents from Parrotia persica-Structural derivatization and their potential prolyl endopeptidase inhibition activity
H Ali, K Ullah, H Siddiqui, S Iqbal, N Goren, SA Ayatollahi, MI Choudhary
Bioorganic Chemistry 96, 103526, 2020
112020
Indole-linked 1, 2, 3-triazole derivatives efficiently modulate COX-2 protein and PGE2 levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kβ nexus
H Jahan, NN Siddiqui, S Iqbal, FZ Basha, MA Khan, T Aslam, ...
Life Sciences 291, 120282, 2022
102022
Synthesis of 1, 2, 3, triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies
H Siddiqui, MAA Baheej, S Ullah, F Rizvi, S Iqbal, HM Haniffa, A Wahab, ...
Molecular Diversity, 1-19, 2021
92021
Synthesis of new bicarbazole-linked triazoles as non-cytotoxic reactive oxygen species (ROS) inhibitors
S Iqbal, MA Khan, Z Ansari, A Jabeen, A Faheem, S Fazal-Ur-Rehman, ...
Synthetic Communications 49 (18), 2330-2341, 2019
92019
Carbazole‐Linked 1,2,3‐Triazoles: In Vitro β‐Glucuronidase Inhibitory Potential, Kinetics, and Molecular Docking Studies
NN Shaikh, S Iqbal, N Syed, MA Khan, ST Moin, MI Choudhary, FZ Basha
ChemistrySelect 4 (20), 6181-6189, 2019
82019
New Benzamide Analogues of Metronidazole‐tethered Triazoles as Non‐sugar Based Inhibitors of β‐Glucuronidase
F Batool, MA Khan, NN Shaikh, S Iqbal, S Akbar, S Fazal‐ur‐rehman, ...
ChemistrySelect 4 (29), 8634-8637, 2019
72019
Synthesis, crystal structure, and reactive oxygen species (ROS) inhibition of N–and O–linked triazole analogues of harmine
S Iqbal, MA Khan, A Jabeen, S Yousuf, F Zafar, F Batool, MU Ganatra, ...
Journal of Molecular Structure 1261, 132796, 2022
42022
Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma
S Iqbal, J Sebhaoui, S Ashraf, M Ozcan, W Kim, B Belmen, G Yeşilyurt, ...
Bioorganic chemistry 147, 107425, 2024
12024
Synthesis of novel tetrahydrobenzo [b] thiophene-3-carbonitrile (THBTC)-based heterocycles: Structural insights, reactivity profiles, and in-silico bioactivity studies
J Sebhaoui, S Ashraf, S Iqbal, M Hajji, B Belmen, G Yeşilyurt, ...
Journal of Molecular Structure 1326, 141110, 2025
2025
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
H Yang, C Zhang, W Kim, M Shi, M Kiliclioglu, C Bayram, I Bolar, ...
eLife 13, RP98427, 2025
2025
PKLR-modulating compounds show promising effects for the treatment of hepatocellular carcinoma
A Mardinoglu, W Kim, H Jin, M Ozcan, X Liao, M Li, S Iqbal, J Sebhaoui, ...
2024
Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4, 5, 6, 7-tetrahydrobenzo [b] thiophen-2-yl) naphthalene-1-sulfonamide derivatives
S Ashraf, S Iqbal, J Sebhaoui, M Ozcan, W Kim, B Belmen, G Yeşilyurt, ...
Journal of Molecular Structure 1312, 138470, 2024
2024
Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins
S Iqbal, MZ Islam, S Ashraf, W Kim, AA Al-Sharabi, M Ozcan, ...
International Journal of Molecular Sciences 25 (14), 7986, 2024
2024
Corrigendum to “Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning”[eBioMedicine, 2022; 83: 104214]
C Zhang, M Shi, W Kim, M Arif, M Klevstig, X Li, H Yang, C Bayram, I Bolat, ...
Ebiomedicine 105, 2024
2024
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
H Yang, C Zhang, W Kim, M Shi, M Kiliclioglu, C Bayram, I Bolat, ...
bioRxiv, 2024.04. 22.590583, 2024
2024
Antioxidant and lipoxygenase inhibition studies of 4-(4-bromophenyl)-2, 2'-bipyridine and its metal complexes Synthesis, characterization and biological screening.
S Fazal-ur-Rehman, AA Wasim, MA Khan, M Ali, S Iqbal
Pakistan Journal of Pharmaceutical Sciences 32, 2019
2019
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