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Andrew Sewell
Andrew Sewell
Distinguished Research Professor
cardiff.ac.uk의 이메일 확인됨 - 홈페이지
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Monoclonal TCR-redirected tumor cell killing
N Liddy, G Bossi, KJ Adams, A Lissina, TM Mahon, NJ Hassan, J Gavarret, ...
Nature medicine 18 (6), 980-987, 2012
10752012
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
DA Price, PJR Goulder, P Klenerman, AK Sewell, PJ Easterbrook, ...
Proceedings of the National Academy of Sciences 94 (5), 1890-1895, 1997
9211997
Why must T cells be cross-reactive?
AK Sewell
Nature Reviews Immunology 12 (9), 669-677, 2012
6242012
A single autoimmune T cell receptor recognizes more than a million different peptides
L Wooldridge, J Ekeruche-Makinde, H Van Den Berg, A Skowera, ...
Journal of Biological Chemistry 287 (2), 1168-1177, 2012
5312012
VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
M Shugay, DV Bagaev, IV Zvyagin, RM Vroomans, JC Crawford, G Dolton, ...
Nucleic acids research 46 (D1), D419-D427, 2018
5072018
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes
A Oxenius, DA Price, PJ Easterbrook, CA O'Callaghan, AD Kelleher, ...
Proceedings of the National Academy of Sciences 97 (7), 3382-3387, 2000
5022000
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
A Skowera, RJ Ellis, R Varela-Calviño, S Arif, GC Huang, C Van-Krinks, ...
The Journal of clinical investigation 118 (10), 3390-3402, 2008
4772008
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
DA Price, JM Brenchley, LE Ruff, MR Betts, BJ Hill, M Roederer, RA Koup, ...
The Journal of experimental medicine 202 (10), 1349-1361, 2005
4772005
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
DV Bagaev, RMA Vroomans, J Samir, U Stervbo, C Rius, G Dolton, ...
Nucleic acids research 48 (D1), D1057-D1062, 2020
3692020
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
JL Chen, G Stewart-Jones, G Bossi, NM Lissin, L Wooldridge, EML Choi, ...
The Journal of experimental medicine 201 (8), 1243-1255, 2005
3252005
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
A Varela-Rohena, PE Molloy, SM Dunn, Y Li, MM Suhoski, RG Carroll, ...
Nature medicine 14 (12), 1390-1395, 2008
3162008
Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
B Laugel, HA van den Berg, E Gostick, DK Cole, L Wooldridge, J Boulter, ...
Journal of Biological Chemistry 282 (33), 23799-23810, 2007
2972007
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
A Leslie, D Kavanagh, I Honeyborne, K Pfafferott, C Edwards, T Pillay, ...
The Journal of experimental medicine 201 (6), 891-902, 2005
2922005
Human TCR-binding affinity is governed by MHC class restriction
DK Cole, NJ Pumphrey, JM Boulter, M Sami, JI Bell, E Gostick, DA Price, ...
The Journal of Immunology 178 (9), 5727-5734, 2007
2812007
The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is …
RE Hewitt, A Lissina, AE Green, ES Slay, DA Price, AK Sewell
Clinical & Experimental Immunology 139 (1), 101-111, 2005
2772005
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
PM Maciocia, PA Wawrzyniecka, B Philip, I Ricciardelli, AU Akarca, ...
Nature medicine 23 (12), 1416-1423, 2017
2752017
Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
MD Crowther, G Dolton, M Legut, ME Caillaud, A Lloyd, M Attaf, ...
Nature immunology 21 (2), 178-185, 2020
2642020
Tricks with tetramers: how to get the most from multimeric peptide–MHC
L Wooldridge, A Lissina, DK Cole, HA Van Den Berg, DA Price, AK Sewell
Immunology 126 (2), 147-164, 2009
2522009
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
SV Pageon, T Tabarin, Y Yamamoto, Y Ma, PR Nicovich, JS Bridgeman, ...
Proceedings of the National Academy of Sciences 113 (37), E5454-E5463, 2016
2502016
CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells
M Legut, G Dolton, AA Mian, OG Ottmann, AK Sewell
Blood, The Journal of the American Society of Hematology 131 (3), 311-322, 2018
2462018
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