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| Simultaneous optimization of biomolecular energy functions on features from small molecules and macromolecules H Park, P Bradley, P Greisen Jr, Y Liu, VK Mulligan, DE Kim, D Baker, ... Journal of chemical theory and computation 12 (12), 6201-6212, 2016 | 495 | 2016 |
| Accurate de novo design of hyperstable constrained peptides G Bhardwaj, VK Mulligan, CD Bahl, JM Gilmore, PJ Harvey, O Cheneval, ... Nature 538 (7625), 329-335, 2016 | 444 | 2016 |
| De novo design of bioactive protein switches RA Langan, SE Boyken, AH Ng, JA Samson, G Dods, AM Westbrook, ... Nature 572 (7768), 205-210, 2019 | 279 | 2019 |
| Comprehensive computational design of ordered peptide macrocycles P Hosseinzadeh, G Bhardwaj, VK Mulligan, MD Shortridge, TW Craven, ... Science 358 (6369), 1461-1466, 2017 | 201 | 2017 |
| Programmable design of orthogonal protein heterodimers Z Chen, SE Boyken, M Jia, F Busch, D Flores-Solis, MJ Bick, P Lu, ... Nature 565 (7737), 106-111, 2019 | 198 | 2019 |
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| Prion disease susceptibility is affected by β-structure folding propensity and local side-chain interactions in PrP MQ Khan, B Sweeting, VK Mulligan, PE Arslan, NR Cashman, EF Pai, ... Proceedings of the National Academy of Sciences 107 (46), 19808-19813, 2010 | 155 | 2010 |
| Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy JH Mills, SD Khare, JM Bolduc, F Forouhar, VK Mulligan, S Lew, ... Journal of the American Chemical Society 135 (36), 13393-13399, 2013 | 135 | 2013 |
| Accurate de novo design of membrane-traversing macrocycles G Bhardwaj, J O’Connor, S Rettie, YH Huang, TA Ramelot, VK Mulligan, ... Cell 185 (19), 3520-3532. e26, 2022 | 107 | 2022 |
| Protein misfolding in the late‐onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis VK Mulligan, A Chakrabartty Proteins: Structure, Function, and Bioinformatics 81 (8), 1285-1303, 2013 | 105 | 2013 |
| Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli C D'Alterio, DDD Tran, MWYA Yeung, MSH Hwang, MA Li, CJ Arana, ... The Journal of cell biology 171 (3), 549-558, 2005 | 83 | 2005 |
| CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization*♦ DF Ceccarelli, RC Laister, VK Mulligan, MJ Kean, M Goudreault, IC Scott, ... Journal of Biological Chemistry 286 (28), 25056-25064, 2011 | 81 | 2011 |
| Early steps in oxidation-induced SOD1 misfolding: implications for non-amyloid protein aggregation in familial ALS VK Mulligan, A Kerman, RC Laister, PR Sharda, PE Arslan, ... Journal of molecular biology 421 (4-5), 631-652, 2012 | 68 | 2012 |
| Denaturational stress induces formation of zinc-deficient monomers of Cu, Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis VK Mulligan, A Kerman, S Ho, A Chakrabartty Journal of molecular biology 383 (2), 424-436, 2008 | 67 | 2008 |
| De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures B Dang, H Wu, VK Mulligan, M Mravic, Y Wu, T Lemmin, A Ford, DA Silva, ... Proceedings of the National Academy of Sciences 114 (41), 10852-10857, 2017 | 64 | 2017 |
| Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites P Hosseinzadeh, PR Watson, TW Craven, X Li, S Rettie, F Pardo-Avila, ... Nature Communications 12 (1), 3384, 2021 | 62 | 2021 |
| ALS-causing SOD1 mutations promote production of copper-deficient misfolded species P Ip, VK Mulligan, A Chakrabartty Journal of molecular biology 409 (5), 839-852, 2011 | 59 | 2011 |
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