Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance L Verkoczy, M Diaz, TM Holl, YB Ouyang, H Bouton-Verville, SM Alam, ... Proceedings of the National Academy of Sciences 107 (1), 181-186, 2010 | 236 | 2010 |
Antibody polyspecificity and neutralization of HIV-1: a hypothesis BF Haynes, MA Moody, L Verkoczy, G Kelsoe, SM Alam Human antibodies 14 (3-4), 59-67, 2005 | 211 | 2005 |
Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ M Diaz, LK Verkoczy, MF Flajnik, N R Klinman The Journal of Immunology 167 (1), 327-335, 2001 | 178 | 2001 |
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation KO Saunders, K Wiehe, M Tian, P Acharya, T Bradley, SM Alam, EP Go, ... Science 366 (6470), eaay7199, 2019 | 150 | 2019 |
Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies L Verkoczy, G Kelsoe, MA Moody, BF Haynes Current opinion in immunology 23 (3), 383-390, 2011 | 128 | 2011 |
Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH× VL knockin mice reveals multiple tolerance controls L Verkoczy, Y Chen, H Bouton-Verville, J Zhang, M Diaz, J Hutchinson, ... The Journal of Immunology 187 (7), 3785-3797, 2011 | 127 | 2011 |
Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection L Verkoczy, B Duong, P Skog, D Aït-Azzouzene, K Puri, JL Vela, ... The Journal of Immunology 178 (10), 6332-6341, 2007 | 125 | 2007 |
Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies MA Moody, I Pedroza-Pacheco, NA Vandergrift, C Chui, KE Lloyd, ... Science immunology 1 (1), aag0851-aag0851, 2016 | 120 | 2016 |
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1 M Bonsignori, K Wiehe, SK Grimm, R Lynch, G Yang, DM Kozink, F Perrin, ... The Journal of clinical investigation 124 (4), 1835-1843, 2014 | 116 | 2014 |
Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages R Zhang, L Verkoczy, K Wiehe, S Munir Alam, NI Nicely, S Santra, ... Science translational medicine 8 (336), 336ra62-336ra62, 2016 | 109 | 2016 |
Vaccine induction of heterologous tier 2 HIV-1 neutralizing antibodies in animal models KO Saunders, LK Verkoczy, C Jiang, J Zhang, R Parks, H Chen, ... Cell reports 21 (13), 3681-3690, 2017 | 107 | 2017 |
Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10 Y Chen, J Zhang, KK Hwang, H Bouton-Verville, SM Xia, A Newman, ... The Journal of Immunology 191 (3), 1260-1275, 2013 | 104 | 2013 |
A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes L Verkoczy, D Aït-Azzouzene, P Skog, A Märtensson, J Lang, B Duong, ... Immunity 22 (4), 519-531, 2005 | 102 | 2005 |
Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against MPER-associated autoreactivity limits T-dependent responses L Verkoczy, Y Chen, J Zhang, H Bouton-Verville, A Newman, B Lockwood, ... The Journal of Immunology 191 (5), 2538-2550, 2013 | 100* | 2013 |
Progress in HIV-1 vaccine development BF Haynes, MA Moody, M Alam, M Bonsignori, L Verkoczy, G Ferrari, ... Journal of Allergy and Clinical Immunology 134 (1), 3-10, 2014 | 89 | 2014 |
An immunoglobulin Cκ-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system D Ait-Azzouzene, L Verkoczy, J Peters, A Gavin, P Skog, JL Vela, ... The Journal of experimental medicine 201 (5), 817-828, 2005 | 88 | 2005 |
Decreased Frequency and Highly Aberrant Spectrum of Ultraviolet-Induced Mutations in the hprt Gene of Mouse Fibroblasts Expressing Antisense RNA to DNA … M Diaz, NB Watson, G Turkington, LK Verkoczy, NR Klinman, ... Molecular cancer research 1 (11), 836-847, 2003 | 86 | 2003 |
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations WB Williams, J Zhang, C Jiang, NI Nicely, D Fera, K Luo, MA Moody, ... Nature communications 8 (1), 1732, 2017 | 85 | 2017 |
HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design M Bonsignori, SM Alam, HX Liao, L Verkoczy, GD Tomaras, BF Haynes, ... Trends in microbiology 20 (11), 532-539, 2012 | 83 | 2012 |
Host controls of HIV neutralizing antibodies BF Haynes, L Verkoczy Science 344 (6184), 588-589, 2014 | 81 | 2014 |