| Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration CA Lindemans, M Calafiore, AM Mertelsmann, MH O’connor, JA Dudakov, ... Nature 528 (7583), 560-564, 2015 | 1076 | 2015 |
| Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ... Science 350 (6266), 1391-1396, 2015 | 961 | 2015 |
| Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer LE Dow, KP O’Rourke, J Simon, DF Tschaharganeh, JH van Es, ... Cell 161 (7), 1539-1552, 2015 | 600 | 2015 |
| Inducible in vivo genome editing with CRISPR-Cas9 LE Dow, J Fisher, KP O'rourke, A Muley, ER Kastenhuber, G Livshits, ... Nature biotechnology 33 (4), 390-394, 2015 | 591 | 2015 |
| Transcriptional plasticity promotes primary and acquired resistance to BET inhibition P Rathert, M Roth, T Neumann, F Muerdter, JS Roe, M Muhar, S Deswal, ... Nature 525 (7570), 543-547, 2015 | 523 | 2015 |
| A rectal cancer organoid platform to study individual responses to chemoradiation K Ganesh, C Wu, KP O’Rourke, BC Szeglin, Y Zheng, CEG Sauvé, ... Nature medicine 25 (10), 1607-1614, 2019 | 449 | 2019 |
| A rapid and scalable system for studying gene function in mice using conditional RNA interference PK Premsrirut, LE Dow, SY Kim, M Camiolo, CD Malone, C Miething, ... Cell 145 (1), 145-158, 2011 | 365 | 2011 |
| Wnt signaling and colorectal cancer EM Schatoff, BI Leach, LE Dow Current colorectal cancer reports 13 (2), 101-110, 2017 | 356 | 2017 |
| Optimized base editors enable efficient editing in cells, organoids and mice MP Zafra, EM Schatoff, A Katti, M Foronda, M Breinig, AY Schweitzer, ... Nature biotechnology 36 (9), 888-893, 2018 | 354 | 2018 |
| CRISPR in cancer biology and therapy A Katti, BJ Diaz, CM Caragine, NE Sanjana, LE Dow Nature Reviews Cancer 22 (5), 259-279, 2022 | 334 | 2022 |
| Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi J Zuber, K McJunkin, C Fellmann, LE Dow, MJ Taylor, GJ Hannon, ... Nature biotechnology 29 (1), 79-83, 2011 | 320 | 2011 |
| A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, ... Immunity 22 (6), 737-748, 2005 | 307 | 2005 |
| Genetic liver-specific AMPK activation protects against diet-induced obesity and NAFLD D Garcia, K Hellberg, A Chaix, M Wallace, S Herzig, MG Badur, T Lin, ... Cell reports 26 (1), 192-208. e6, 2019 | 266 | 2019 |
| p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer DF Tschaharganeh, W Xue, DF Calvisi, M Evert, TV Michurina, LE Dow, ... Cell 158 (3), 579-592, 2014 | 265 | 2014 |
| Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer KP O'Rourke, E Loizou, G Livshits, EM Schatoff, T Baslan, E Manchado, ... Nature biotechnology 35 (6), 577-582, 2017 | 249 | 2017 |
| Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis B Palikuqi, DHT Nguyen, G Li, R Schreiner, AF Pellegata, Y Liu, ... Nature 585 (7825), 426-432, 2020 | 215 | 2020 |
| SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia HB Pearson, PA Perez-Mancera, LE Dow, A Ryan, P Tennstedt, D Bogani, ... The Journal of clinical investigation 121 (11), 4257-4267, 2011 | 213 | 2011 |
| Dietary fructose improves intestinal cell survival and nutrient absorption SR Taylor, S Ramsamooj, RJ Liang, A Katti, R Pozovskiy, N Vasan, ... Nature 597 (7875), 263-267, 2021 | 212 | 2021 |
| A pipeline for the generation of shRNA transgenic mice LE Dow, PK Premsrirut, J Zuber, C Fellmann, K McJunkin, C Miething, ... Nature protocols 7 (2), 374-393, 2012 | 207 | 2012 |
| Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition JE Bolden, N Tasdemir, LE Dow, JH van Es, JE Wilkinson, Z Zhao, ... Cell reports 8 (6), 1919-1929, 2014 | 206 | 2014 |