Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase I Pecsi, I Leveles, V Harmat, BG Vertessy, J Toth Nucleic acids research 38 (20), 7179-7186, 2010 | 79 | 2010 |
Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control JE Szabo, V Németh, V Papp-Kádár, K Nyíri, I Leveles, AA Bendes, ... Nucleic acids research 42 (19), 11912-11920, 2014 | 60 | 2014 |
Preventive DNA repair by sanitizing the cellular (deoxy) nucleoside triphosphate pool GN Nagy, I Leveles, BG Vértessy The FEBS journal 281 (18), 4207-4223, 2014 | 57 | 2014 |
Regulation of the equilibrium between closed and open conformations of annexin A2 by N-terminal phosphorylation and S100A4-binding P Ecsédi, B Kiss, G Gógl, L Radnai, L Buday, K Koprivanacz, K Liliom, ... Structure 25 (8), 1195-1207. e5, 2017 | 53 | 2017 |
Structural characterization of arginine fingers: identification of an arginine finger for the pyrophosphatase dUTPases GN Nagy, R Suardíaz, A Lopata, O Ozohanics, K Vékey, BR Brooks, ... Journal of the American Chemical Society 138 (45), 15035-15045, 2016 | 49 | 2016 |
Structure and enzymatic mechanism of a moonlighting dUTPase I Leveles, V Németh, JE Szabó, V Harmat, K Nyíri, ÁÁ Bendes, ... Biological Crystallography 69 (12), 2298-2308, 2013 | 37 | 2013 |
A novel fruitfly protein under developmental control degrades uracil-DNA A Békési, M Pukáncsik, V Muha, I Zagyva, I Leveles, E Hunyadi-Gulyás, ... Biochemical and biophysical research communications 355 (3), 643-648, 2007 | 34 | 2007 |
Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases E Takács, G Nagy, I Leveles, V Harmat, A Lopata, J Tóth, BG Vértessy FEBS letters 584 (14), 3047-3054, 2010 | 32 | 2010 |
Substrate tunnel engineering aided by X-ray crystallography and functional dynamics swaps the function of MIO-enzymes Z Bata, Z Molnar, E Madaras, B Molnar, E Santa-Bell, A Varga, I Leveles, ... ACS catalysis 11 (8), 4538-4549, 2021 | 30 | 2021 |
The First Enantioselective Total Synthesis of (−)-trans-Dihydronarciclasine G Varró, L Hegedűs, A Simon, A Balogh, A Grün, I Leveles, ... Journal of Natural Products 80 (6), 1909-1917, 2017 | 24 | 2017 |
Molecular dynamics of the cryo-EM CFTR structure H Tordai, I Leveles, T Hegedűs Biochemical and Biophysical Research Communications 491 (4), 986-993, 2017 | 22 | 2017 |
The electrical conductivity of living tissue: a parameter in the bioelectrical inverse problem MJ Peters, JG Stinstra, I Leveles Modeling and Imaging of Bioelectrical Activity: Principles and Applications …, 2005 | 21 | 2005 |
Beyond chelation: EDTA tightly binds taq DNA polymerase, MutT and dUTPase and directly inhibits dNTPase activity A Lopata, B Jójárt, ÉV Surányi, E Takács, L Bezúr, I Leveles, ÁÁ Bendes, ... Biomolecules 9 (10), 621, 2019 | 18 | 2019 |
A hidden active site in the potential drug target mycobacterium tuberculosis dUTPase is accessible through small amplitude protein conformational changes A Lopata, I Leveles, ÁÁ Bendes, B Viskolcz, BG Vértessy, B Jójárt, J Tóth Journal of Biological Chemistry 291 (51), 26320-26331, 2016 | 18 | 2016 |
Structural insights into the tyrosine phosphorylation–mediated inhibition of SH3 domain–ligand interactions B Merő, L Radnai, G Gógl, O Tőke, I Leveles, K Koprivanacz, B Szeder, ... Journal of Biological Chemistry 294 (12), 4608-4620, 2019 | 16 | 2019 |
Origin of problems related to Staudinger reduction in carbopeptoid syntheses B Csordás, A Nagy, V Harmat, V Zsoldos-Mády, I Leveles, I Pintér, ... Amino Acids 48, 2619-2633, 2016 | 13 | 2016 |
Crystallization and preliminary crystallographic analysis of dUTPase from the φ11 helper phage of Staphylococcus aureus I Leveles, G Róna, I Zagyva, Á Bendes, V Harmat, BG Vértessy Structural Biology and Crystallization Communications 67 (11), 1411-1413, 2011 | 12 | 2011 |
Structural characterization of a complex derived from lead (II) perchlorate and acridono-18-crown-6 ether T Németh, Á Golcs, I Leveles, T Tóth, BG Vértessy, P Huszthy Structural Chemistry 26, 1467-1471, 2015 | 11 | 2015 |
An acridone‐based fluorescent chemosensor for cationic and anionic species, and its application for molecular logic operations D Pál, P Baranyai, I Leveles, BG Vértessy, P Huszthy, I Móczár ChemistrySelect 4 (40), 11936-11943, 2019 | 10 | 2019 |
The role of a key amino acid position in species-specific proteinaceous dUTPase inhibition A Benedek, F Temesváry-Kis, T Khatanbaatar, I Leveles, ÉV Surányi, ... Biomolecules 9 (6), 221, 2019 | 10 | 2019 |