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Gareth R. Howell
Gareth R. Howell
Professor, The Jackson Laboratory
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The classical complement cascade mediates CNS synapse elimination
B Stevens, NJ Allen, LE Vazquez, GR Howell, KS Christopherson, ...
Cell 131 (6), 1164-1178, 2007
34372007
The DNA sequence of the human X chromosome
MT Ross, DV Grafham, AJ Coffey, S Scherer, K McLay, D Muzny, ...
Nature 434 (7031), 325-337, 2005
14392005
Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
AJ Coffey, RA Brooksbank, O Brandau, T Oohashi, GR Howell, JM Bye, ...
Nature genetics 20 (2), 129-135, 1998
8981998
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse modelsTREM2 expression and function in AD
TR Jay, CM Miller, PJ Cheng, LC Graham, S Bemiller, ML Broihier, G Xu, ...
The Journal of experimental medicine 212 (3), 287-295, 2015
7432015
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
GR Howell, RT Libby, TC Jakobs, RS Smith, FC Phalan, JW Barter, ...
The Journal of cell biology 179 (7), 1523-1537, 2007
6602007
The DNA sequence and analysis of human chromosome 6
AJ Mungall, SA Palmer, SK Sims, CA Edwards, JL Ashurst, L Wilming, ...
Nature 425 (6960), 805-811, 2003
5462003
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
GR Howell, DG Macalinao, GL Sousa, M Walden, I Soto, SC Kneeland, ...
The Journal of clinical investigation 121 (4), 1429-1444, 2011
4802011
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
CA Tagge, AM Fisher, OV Minaeva, A Gaudreau-Balderrama, ...
Brain 141 (2), 422-458, 2018
4462018
Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
RW Nickells, GR Howell, I Soto, SWM John
Annual review of neuroscience 35, 153-179, 2012
3962012
A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation
A Carrié, L Jun, T Bienvenu, MC Vinet, N McDonell, P Couvert, R Zemni, ...
Nature genetics 23 (1), 25-31, 1999
3451999
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma
JNC Bailey, SJ Loomis, JH Kang, RR Allingham, P Gharahkhani, CC Khor, ...
Nature genetics 48 (2), 189-194, 2016
2822016
A robust system for RNA interference in the chicken using a modified microRNA operon
RM Das, NJ Van Hateren, GR Howell, ER Farrell, FK Bangs, VC Porteous, ...
Developmental biology 294 (2), 554-563, 2006
2462006
Meta-analysis of the Alzheimer’s disease human brain transcriptome and functional dissection in mouse models
YW Wan, R Al-Ouran, CG Mangleburg, TM Perumal, TV Lee, K Allison, ...
Cell reports 32 (2), 107908, 2020
2442020
Neuroinflammation in glaucoma: A new opportunity
PA Williams, N Marsh-Armstrong, GR Howell, A Bosco, J Danias, J Simon, ...
Experimental eye research 157, 20-27, 2017
2442017
The complex role of neuroinflammation in glaucoma
I Soto, GR Howell
Cold Spring Harbor perspectives in medicine 4 (8), a017269, 2014
2412014
Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma
GR Howell, I Soto, X Zhu, M Ryan, DG Macalinao, GL Sousa, LB Caddle, ...
The Journal of clinical investigation 122 (4), 1246-1261, 2012
2382012
Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study
AL Oblak, PB Lin, KP Kotredes, RS Pandey, D Garceau, HM Williams, ...
Frontiers in aging neuroscience 13, 713726, 2021
2352021
Mutations in the RNA granule component TDRD7 cause cataract and glaucoma
SA Lachke, FS Alkuraya, SC Kneeland, T Ohn, A Aboukhalil, GR Howell, ...
Science 331 (6024), 1571-1576, 2011
2132011
Toward more predictive genetic mouse models of Alzheimer's disease
KD Onos, SJS Rizzo, GR Howell, M Sasner
Brain research bulletin 122, 1-11, 2016
1862016
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
PA Williams, JR Tribble, KW Pepper, SD Cross, BP Morgan, JE Morgan, ...
Molecular neurodegeneration 11, 1-13, 2016
1842016
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