| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, ... Nature genetics 42 (2), 105-116, 2010 | 2612 | 2010 |
| Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis BF Voight, LJ Scott, V Steinthorsdottir, AP Morris, C Dina, RP Welch, ... Nature genetics 42 (7), 579-589, 2010 | 2221 | 2010 |
| Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps A Mahajan, D Taliun, M Thurner, NR Robertson, JM Torres, NW Rayner, ... Nature genetics 50 (11), 1505-1513, 2018 | 1769 | 2018 |
| Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6. 2 and permanent neonatal diabetes AL Gloyn, ER Pearson, JF Antcliff, P Proks, GJ Bruining, AS Slingerland, ... New England Journal of Medicine 350 (18), 1838-1849, 2004 | 1498 | 2004 |
| The genetic architecture of type 2 diabetes C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, ... Nature 536 (7614), 41-47, 2016 | 1307 | 2016 |
| Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6. 2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant … AL Gloyn, MN Weedon, KR Owen, MJ Turner, BA Knight, G Hitman, ... Diabetes 52 (2), 568-572, 2003 | 1036 | 2003 |
| Parental origin of sequence variants associated with complex diseases A Kong, V Steinthorsdottir, G Masson, G Thorleifsson, P Sulem, ... Nature 462 (7275), 868-874, 2009 | 673 | 2009 |
| Update on mutations in glucokinase (GCK), which cause maturity‐onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia KK Osbak, K Colclough, C Saint‐Martin, NL Beer, C Bellanné‐Chantelot, ... Human mutation 30 (11), 1512-1526, 2009 | 617 | 2009 |
| Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants L Pasquali, KJ Gaulton, SA Rodríguez-Seguí, L Mularoni, ... Nature genetics 46 (2), 136-143, 2014 | 596 | 2014 |
| Mutations in PTF1A cause pancreatic and cerebellar agenesis GS Sellick, KT Barker, I Stolte-Dijkstra, C Fleischmann, R J Coleman, ... Nature genetics 36 (12), 1301-1305, 2004 | 522 | 2004 |
| The trans-ancestral genomic architecture of glycemic traits J Chen, CN Spracklen, G Marenne, A Varshney, LJ Corbin, J Luan, ... Nature genetics 53 (6), 840-860, 2021 | 520 | 2021 |
| Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes I Morán, I Akerman, M Van De Bunt, R Xie, M Benazra, T Nammo, L Arnes, ... Cell metabolism 16 (4), 435-448, 2012 | 500 | 2012 |
| Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes RJ Strawbridge, J Dupuis, I Prokopenko, A Barker, E Ahlqvist, D Rybin, ... Diabetes 60 (10), 2624-2634, 2011 | 470 | 2011 |
| Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation A Mahajan, CN Spracklen, W Zhang, MCY Ng, LE Petty, H Kitajima, ... Nature genetics 54 (5), 560-572, 2022 | 461 | 2022 |
| The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in … NL Beer, ND Tribble, LJ McCulloch, C Roos, PRV Johnson, ... Human molecular genetics 18 (21), 4081-4088, 2009 | 458 | 2009 |
| Permanent Neonatal Diabetes due to Mutations in KCNJ11 Encoding Kir6.2: Patient Characteristics and Initial Response to Sulfonylurea Therapy JV Sagen, H Ræder, E Hathout, N Shehadeh, K Gudmundsson, H Bævre, ... Diabetes 53 (10), 2713-2718, 2004 | 457 | 2004 |
| Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood SE Flanagan, AM Patch, DJG Mackay, EL Edghill, AL Gloyn, D Robinson, ... Diabetes 56 (7), 1930-1937, 2007 | 456 | 2007 |
| Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci KJ Gaulton, T Ferreira, Y Lee, A Raimondo, R Mägi, ME Reschen, ... Nature genetics 47 (12), 1415-1425, 2015 | 436 | 2015 |
| Identification of type 2 diabetes loci in 433,540 East Asian individuals CN Spracklen, M Horikoshi, YJ Kim, K Lin, F Bragg, S Moon, K Suzuki, ... Nature 582 (7811), 240-245, 2020 | 398 | 2020 |
| Glucokinase (GCK) mutations in hyper‐ and hypoglycemia: Maturity‐onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy AL Gloyn Human mutation 22 (5), 353-362, 2003 | 372 | 2003 |