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J. Andrew Alspaugh
J. Andrew Alspaugh
Professor of Medicine, Duke University School of Medicine
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Cryptococcus neoformans mating and virulence are regulated by the G-protein α subunit GPA1 and cAMP
JA Alspaugh, JR Perfect, J Heitman
Genes & development 11 (23), 3206-3217, 1997
4941997
The Cryptococcus neoformans capsule: a sword and a shield
TR O'Meara, JA Alspaugh
Clinical microbiology reviews 25 (3), 387-408, 2012
4002012
Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans
CA D'Souza, JA Alspaugh, C Yue, T Harashima, GM Cox, JR Perfect, ...
Molecular and cellular biology, 2001
3862001
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans
JA Alspaugh, LM Cavallo, JR Perfect, J Heitman
Molecular microbiology 36 (2), 352-365, 2000
2812000
Adenylyl Cyclase Functions Downstream of the Gα Protein Gpa1 and Controls Mating and Pathogenicity of Cryptococcus neoformans
JA Alspaugh, R Pukkila-Worley, T Harashima, LM Cavallo, D Funnell, ...
Eukaryotic cell 1 (1), 75-84, 2002
2512002
New horizons in antifungal therapy
KM Pianalto, JA Alspaugh
Journal of Fungi 2 (4), 26, 2016
2432016
Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans
RC Davidson, MC Cruz, RAL Sia, B Allen, JA Alspaugh, J Heitman
Fungal Genetics and Biology 29 (1), 38-48, 2000
2222000
Interaction of Cryptococcus neoformans Rim101 and Protein Kinase A Regulates Capsule
TR O'Meara, D Norton, MS Price, C Hay, MF Clements, CB Nichols, ...
PLoS pathogens 6 (2), e1000776, 2010
2212010
Transcriptional Network of Multiple Capsule and Melanin Genes Governed by the Cryptococcus neoformans Cyclic AMP Cascade
R Pukkila-Worley, QD Gerrald, PR Kraus, MJ Boily, MJ Davis, SS Giles, ...
Eukaryotic cell 4 (1), 190-201, 2005
2172005
Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis
JA Alspaugh, DL Granger
Infection and Immunity 59 (7), 2291-2296, 1991
2161991
Differential Effects of Inhibiting Chitin and 1,3-β-d-Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus
JR Fortwendel, PR Juvvadi, N Pinchai, BZ Perfect, JA Alspaugh, ...
Antimicrobial agents and chemotherapy 53 (2), 476-482, 2009
1762009
Virulence mechanisms and Cryptococcus neoformans pathogenesis
JA Alspaugh
Fungal Genetics and Biology 78, 55-58, 2015
1692015
The STE12α homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans
C Yue, LM Cavallo, JA Alspaugh, P Wang, GM Cox, JR Perfect, J Heitman
Genetics 153 (4), 1601-1615, 1999
1671999
Signal Transduction Pathways Regulating Differentiation and Pathogenicity ofCryptococcus neoformans
JA Alspaugh, JR Perfect, J Heitman
Fungal Genetics and Biology 25 (1), 1-14, 1998
1361998
Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses
TR O'Meara, SM Holmer, K Selvig, F Dietrich, JA Alspaugh
MBio 4 (1), 10.1128/mbio. 00522-12, 2013
1342013
Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli
LH Okagaki, Y Wang, ER Ballou, TR O'Meara, YS Bahn, JA Alspaugh, ...
Eukaryotic cell 10 (10), 1306-1316, 2011
1322011
pH response pathways in fungi: adapting to host-derived and environmental signals
K Selvig, JA Alspaugh
Mycobiology 39 (4), 249-256, 2011
1302011
Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans
MS Waugh, CB Nichols, CM DeCesare, GM Cox, J Heitman, JA Alspaugh
Microbiology 148 (1), 191-201, 2002
1302002
The Cryptococcus neoformans Catalase Gene Family and Its Role in Antioxidant Defense
SS Giles, JE Stajich, C Nichols, QD Gerrald, JA Alspaugh, F Dietrich, ...
Eukaryotic Cell 5 (9), 1447-1459, 2006
1292006
A Ras1‐Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans
CB Nichols, ZH Perfect, JA Alspaugh
Molecular microbiology 63 (4), 1118-1130, 2007
1252007
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