| Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism AK Thakur, M Jayaraman, R Mishra, M Thakur, VM Chellgren, IJ L Byeon, ... Nature structural & molecular biology 16 (4), 380-389, 2009 | 490 | 2009 |
| The toxicological mechanisms of environmental soot (black carbon) and carbon black: focus on oxidative stress and inflammatory pathways R Niranjan, AK Thakur Frontiers in immunology 8, 763, 2017 | 356 | 2017 |
| Oligoproline effects on polyglutamine conformation and aggregation A Bhattacharyya, AK Thakur, VM Chellgren, G Thiagarajan, AD Williams, ... Journal of molecular biology 355 (3), 524-535, 2006 | 307 | 2006 |
| Mutational analysis of the structural organization of polyglutamine aggregates AK Thakur, R Wetzel Proceedings of the National Academy of Sciences 99 (26), 17014-17019, 2002 | 242 | 2002 |
| Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments M Jayaraman, R Kodali, B Sahoo, AK Thakur, A Mayasundari, R Mishra, ... Journal of molecular biology 415 (5), 881-899, 2012 | 213 | 2012 |
| Polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction AM Bhattacharyya, AK Thakur, R Wetzel Proceedings of the National Academy of Sciences 102 (43), 15400-15405, 2005 | 182 | 2005 |
| Kinetics and thermodynamics of amyloid assembly using a high‐performance liquid chromatography–based sedimentation assay B O'Nuallain, AK Thakur, AD Williams, AM Bhattacharyya, S Chen, ... Methods in enzymology 413, 34-74, 2006 | 169 | 2006 |
| Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria V Singh, RK Rai, A Arora, N Sinha, AK Thakur Scientific reports 4 (1), 3875, 2014 | 141 | 2014 |
| Understanding the self-assembly of Fmoc–phenylalanine to hydrogel formation V Singh, K Snigdha, C Singh, N Sinha, AK Thakur Soft Matter 11 (26), 5353-5364, 2015 | 121 | 2015 |
| Fmoc-phenylalanine displays antibacterial activity against Gram-positive bacteria in gel and solution phases AY Gahane, P Ranjan, V Singh, RK Sharma, N Sinha, M Sharma, ... Soft matter 14 (12), 2234-2244, 2018 | 99 | 2018 |
| Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates R Mishra, M Jayaraman, BP Roland, E Landrum, T Fullam, R Kodali, ... Journal of molecular biology 415 (5), 900-917, 2012 | 97 | 2012 |
| Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties M Jayaraman, R Mishra, R Kodali, AK Thakur, LMI Koharudin, ... Biochemistry 51 (13), 2706-2716, 2012 | 88 | 2012 |
| In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence Z Ignatova, AK Thakur, R Wetzel, LM Gierasch Journal of Biological Chemistry 282 (50), 36736-36743, 2007 | 68 | 2007 |
| CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity M Arango, S Holbert, D Zala, E Brouillet, J Pearson, E Régulier, ... Journal of Neuroscience 26 (17), 4649-4659, 2006 | 60 | 2006 |
| Inhibition of polyglutamine aggregate cytotoxicity by a structure‐based elongation inhibitor AK Thakur, W Yang, R Wetzel The FASEB journal 18 (7), 923-925, 2004 | 53 | 2004 |
| Inhibition of cyclooxygenase-2 (COX-2) initiates autophagy and potentiates MPTP-induced autophagic cell death of human neuroblastoma cells, SH-SY5Y: an inside in the pathology … R Niranjan, KP Mishra, AK Thakur Molecular neurobiology 55, 8038-8050, 2018 | 42 | 2018 |
| Biodegradable nanoparticles containing mechanism based peptide inhibitors reduce polyglutamine aggregation in cell models and alleviate motor symptoms in a Drosophila model of … AS Joshi, V Singh, A Gahane, AK Thakur ACS Chemical Neuroscience 10 (3), 1603-1614, 2018 | 38 | 2018 |
| Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux A Rai, PK Singh, V Singh, V Kumar, R Mishra, AK Thakur, A Mahadevan, ... Cell death & disease 9 (2), 201, 2018 | 37 | 2018 |
| Assays for studying nucleated aggregation of polyglutamine proteins M Jayaraman, AK Thakur, K Kar, R Kodali, R Wetzel Methods 53 (3), 246-254, 2011 | 37 | 2011 |
| Development of mechanism-based antibacterial synergy between Fmoc-phenylalanine hydrogel and aztreonam AY Gahane, V Singh, A Kumar, AK Thakur Biomaterials science 8 (7), 1996-2006, 2020 | 31 | 2020 |
