| PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes VK Mootha, CM Lindgren, KF Eriksson, A Subramanian, S Sihag, J Lehar, ... Nature genetics 34 (3), 267-273, 2003 | 10802 | 2003 |
| Resveratrol improves health and survival of mice on a high-calorie diet JA Baur, KJ Pearson, NL Price, HA Jamieson, C Lerin, A Kalra, ... Nature 444 (7117), 337-342, 2006 | 5463 | 2006 |
| Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 Z Wu, P Puigserver, U Andersson, C Zhang, G Adelmant, V Mootha, ... Cell 98 (1), 115-124, 1999 | 4920 | 1999 |
| Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α M Lagouge, C Argmann, Z Gerhart-Hines, H Meziane, C Lerin, F Daussin, ... Cell 127 (6), 1109-1122, 2006 | 4888 | 2006 |
| A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis P Puigserver, Z Wu, CW Park, R Graves, M Wright, BM Spiegelman Cell 92 (6), 829-839, 1998 | 4837 | 1998 |
| Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1 JT Rodgers, C Lerin, W Haas, SP Gygi, BM Spiegelman, P Puigserver Nature 434 (7029), 113-118, 2005 | 3866 | 2005 |
| AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity C Cantó, Z Gerhart-Hines, JN Feige, M Lagouge, L Noriega, JC Milne, ... Nature 458 (7241), 1056-1060, 2009 | 3623 | 2009 |
| Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres J Lin, H Wu, PT Tarr, CY Zhang, Z Wu, O Boss, LF Michael, P Puigserver, ... Nature 418 (6899), 797-801, 2002 | 3146 | 2002 |
| Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator P Puigserver, BM Spiegelman Endocrine reviews 24 (1), 78-90, 2003 | 2575 | 2003 |
| Transcriptional regulation of adipogenesis ED Rosen, CJ Walkey, P Puigserver, BM Spiegelman Genes & development 14 (11), 1293-1307, 2000 | 2540 | 2000 |
| Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 JC Yoon, P Puigserver, G Chen, J Donovan, Z Wu, J Rhee, G Adelmant, ... Nature 413 (6852), 131-138, 2001 | 2300 | 2001 |
| Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction P Puigserver, J Rhee, J Donovan, CJ Walkey, JC Yoon, F Oriente, ... Nature 423 (6939), 550-555, 2003 | 1763 | 2003 |
| CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 S Herzig, F Long, US Jhala, S Hedrick, R Quinn, A Bauer, D Rudolph, ... Nature 413 (6852), 179-183, 2001 | 1748 | 2001 |
| mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex JT Cunningham, JT Rodgers, DH Arlow, F Vazquez, VK Mootha, ... nature 450 (7170), 736-740, 2007 | 1722 | 2007 |
| Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α Z Gerhart‐Hines, JT Rodgers, O Bare, C Lerin, SH Kim, R Mostoslavsky, ... The EMBO journal 26 (7), 1913-1923, 2007 | 1510 | 2007 |
| SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis D Kim, MD Nguyen, MM Dobbin, A Fischer, F Sananbenesi, JT Rodgers, ... The EMBO journal 26 (13), 3169-3179, 2007 | 1311 | 2007 |
| Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment ZT Schafer, AR Grassian, L Song, Z Jiang, Z Gerhart-Hines, HY Irie, ... Nature 461 (7260), 109-113, 2009 | 1158 | 2009 |
| Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1 P Puigserver, J Rhee, J Lin, Z Wu, JC Yoon, CY Zhang, S Krauss, ... Molecular cell 8 (5), 971-982, 2001 | 970 | 2001 |
| An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle C Handschin, J Rhee, J Lin, PT Tarr, BM Spiegelman Proceedings of the national academy of sciences 100 (12), 7111-7116, 2003 | 949 | 2003 |
| Exercise stimulates Pgc-1α transcription in skeletal muscle through activation of the p38 MAPK pathway T Akimoto, SC Pohnert, P Li, M Zhang, C Gumbs, PB Rosenberg, ... Journal of Biological Chemistry 280 (20), 19587-19593, 2005 | 914 | 2005 |
Bruce M. SpiegelmanStanley J. Korsmeyer Professor, Harvard Medical School and Dana-Farber Cancer InstitutePatvirtintas el. paštas dfci.harvard.edu
