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| Apolipoprotein E and Alzheimer's disease: findings, hypotheses, and potential mechanisms N Koutsodendris, MR Nelson, A Rao, Y Huang Annual Review of Pathology: Mechanisms of Disease 17 (1), 73-99, 2022 | 173 | 2022 |
| Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease KA Zalocusky, R Najm, AL Taubes, Y Hao, SY Yoon, N Koutsodendris, ... Nature neuroscience 24 (6), 786-798, 2021 | 140 | 2021 |
| APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia MS Haney, R Pálovics, CN Munson, C Long, PK Johansson, O Yip, ... Nature 628 (8006), 154-161, 2024 | 139 | 2024 |
| Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease A Taubes, P Nova, KA Zalocusky, I Kosti, M Bicak, MY Zilberter, Y Hao, ... Nature Aging 1 (10), 932-947, 2021 | 92 | 2021 |
| Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits N Koutsodendris, J Blumenfeld, A Agrawal, M Traglia, B Grone, ... Nature Aging 3 (3), 275-296, 2023 | 77 | 2023 |
| The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation MR Nelson, P Liu, A Agrawal, O Yip, J Blumenfeld, M Traglia, MJ Kim, ... Nature Neuroscience 26 (12), 2104-2121, 2023 | 43 | 2023 |
| In vivo chimeric Alzheimer’s disease modeling of apolipoprotein E4 toxicity in human neurons R Najm, KA Zalocusky, M Zilberter, SY Yoon, Y Hao, N Koutsodendris, ... Cell reports 32 (4), 2020 | 40 | 2020 |
| Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo KA Staats, C Seah, A Sahimi, Y Wang, N Koutsodendris, S Lin, D Kim, ... BioRxiv, 685800, 2019 | 23 | 2019 |
| Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1 EAA Jones, A Rao, M Zilberter, B Djukic, JS Bant, AK Gillespie, ... Cell reports 37 (13), 2021 | 22 | 2021 |
| APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia MS Haney, R Pálovics, CN Munson, C Long, P Johansson, O Yip, ... bioRxiv, 2023 | 13 | 2023 |
| APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release N Koutsodendris, J Blumenfeld, A Agrawal, M Traglia, O Yip, A Rao, ... Cell reports 42 (10), 2023 | 9 | 2023 |
| Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model A Rao, N Chen, MJ Kim, J Blumenfeld, O Yip, Z Liang, D Shostak, Y Hao, ... Cell Stem Cell 32 (1), 86-104. e7, 2025 | 3 | 2025 |
| Microglia depletion reduces human neuronal APOE4-driven pathologies in a chimeric Alzheimer’s disease model A Rao, N Chen, MJ Kim, J Blumenfeld, O Yip, Y Hao, Z Liang, MR Nelson, ... bioRxiv, 2023 | 3 | 2023 |
| Neuronal apoE4 induces early hyperexcitability in select populations of hippocampal neurons by altering Nell2 expression SS Jang, DR Tabuena, B Grone, O Yip, J Blumenfeld, N Koutsodendris, ... bioRxiv, 2023 | 3* | 2023 |
| Mechanisms of APOE4-Driven Pathogenesis in Alzheimer's Disease and Related Therapeutic Approaches N Koutsodendris University of California, San Francisco, 2022 | | 2022 |
| Mechanisms of APOE4-Driven Alzheimer’s Disease Pathogenesis and Related Therapeutic Approaches N Koutsodendris UCSF, 2022 | | 2022 |
| Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease A Alice Taubes, P Nova, KA Zalocusky, I Kosti, M Bicak, MY Zilberter, ... Nature Publishing Group, 2021 | | 2021 |