| SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function NL Price, AP Gomes, AJY Ling, FV Duarte, A Martin-Montalvo, BJ North, ... Cell metabolism 15 (5), 675-690, 2012 | 1732 | 2012 |
| Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging AP Gomes, NL Price, AJY Ling, JJ Moslehi, MK Montgomery, L Rajman, ... Cell 155 (7), 1624-1638, 2013 | 1552 | 2013 |
| Kinase-targeted cancer therapies: progress, challenges and future directions KS Bhullar, NO Lagarón, EM McGowan, I Parmar, A Jha, BP Hubbard, ... Molecular cancer 17, 1-20, 2018 | 1289 | 2018 |
| Evidence for a common mechanism of SIRT1 regulation by allosteric activators BP Hubbard, AP Gomes, H Dai, J Li, AW Case, T Considine, TV Riera, ... Science 339 (6124), 1216-1219, 2013 | 676 | 2013 |
| Small molecule SIRT1 activators for the treatment of aging and age-related diseases BP Hubbard, DA Sinclair Trends in pharmacological sciences 35 (3), 146-154, 2014 | 660 | 2014 |
| SRT1720 improves survival and healthspan of obese mice RK Minor, JA Baur, AP Gomes, TM Ward, A Csiszar, EM Mercken, ... Scientific reports 1 (1), 70, 2011 | 342 | 2011 |
| Lifespan and healthspan extension by resveratrol KS Bhullar, BP Hubbard Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (6 …, 2015 | 334 | 2015 |
| SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator H Dai, L Kustigian, D Carney, A Case, T Considine, BP Hubbard, ... Journal of Biological Chemistry 285 (43), 32695-32703, 2010 | 263 | 2010 |
| A conserved NAD+ binding pocket that regulates protein-protein interactions during aging J Li, MS Bonkowski, S Moniot, D Zhang, BP Hubbard, AJY Ling, ... Science 355 (6331), 1312-1317, 2017 | 230 | 2017 |
| Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity CR Cromwell, K Sung, J Park, AR Krysler, J Jovel, SK Kim, BP Hubbard Nature communications 9 (1), 1448, 2018 | 188 | 2018 |
| Structural study of Maya Blue: textural, thermal and solid-state multinuclear magnetic resonance characterization of the palygorskite-indigo and sepiolite-indigo adducts B Hubbard, W Kuang, A Moser, GA Facey, C Detellier Clays and clay minerals 51 (3), 318-326, 2003 | 180 | 2003 |
| Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis AP Gomes, FV Duarte, P Nunes, BP Hubbard, JS Teodoro, AT Varela, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (2), 185-195, 2012 | 170 | 2012 |
| Continuous directed evolution of DNA-binding proteins to improve TALEN specificity BP Hubbard, AH Badran, JA Zuris, JP Guilinger, KM Davis, L Chen, ... Nature methods 12 (10), 939-942, 2015 | 156 | 2015 |
| Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein M Bernier, RK Paul, A Martin-Montalvo, M Scheibye-Knudsen, S Song, ... Journal of Biological Chemistry 286 (22), 19270-19279, 2011 | 154 | 2011 |
| JNK phosphorylates SIRT6 to stimulate DNA double-strand break repair in response to oxidative stress by recruiting PARP1 to DNA breaks M Van Meter, M Simon, G Tombline, A May, TD Morello, BP Hubbard, ... Cell reports 16 (10), 2641-2650, 2016 | 146 | 2016 |
| The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction B Rascón, BP Hubbard, DA Sinclair, GV Amdam Aging (Albany NY) 4 (7), 499, 2012 | 141 | 2012 |
| Identification of a SIRT1 mutation in a family with type 1 diabetes A Biason-Lauber, M Böni-Schnetzler, BP Hubbard, K Bouzakri, A Brunner, ... Cell metabolism 17 (3), 448-455, 2013 | 135 | 2013 |
| Characterization of murine SIRT3 transcript variants and corresponding protein products Y Yang, BP Hubbard, DA Sinclair, Q Tong Journal of cellular biochemistry 111 (4), 1051-1058, 2010 | 49 | 2010 |
| Evolution of TALENs DR Liu, B Hubbard, AH Badran US Patent 10,612,011, 2020 | 42 | 2020 |
| Evolution of TALENs DR Liu, B Hubbard, AH Badran US Patent 11,078,469, 2021 | 37 | 2021 |
David A. SinclairHarvard Medical School (Genetics)Patvirtintas el. paštas hms.harvard.edu