| Computationally designed libraries for rapid enzyme stabilization HJ Wijma, RJ Floor, PA Jekel, D Baker, SJ Marrink, DB Janssen Protein Engineering, Design & Selection 27 (2), 49-58, 2014 | 307 | 2014 |
| Structure-and sequence-analysis inspired engineering of proteins for enhanced thermostability HJ Wijma, RJ Floor, DB Janssen Current opinion in structural biology 23 (4), 588-594, 2013 | 227 | 2013 |
| Computational redesign of enzymes for regio-and enantioselective hydroamination R Li, HJ Wijma, L Song, Y Cui, M Otzen, Y Tian, J Du, T Li, D Niu, Y Chen, ... Nature chemical biology 14 (7), 664-670, 2018 | 206 | 2018 |
| Enantioselective enzymes by computational design and in silico screening HJ Wijma, RJ Floor, S Bjelic, SJ Marrink, D Baker, DB Janssen Angewandte Chemie International Edition 54 (12), 3726-3730, 2015 | 163 | 2015 |
| Real-time conformational changes and controlled orientation of native proteins inside a protein nanoreactor V Van Meervelt, M Soskine, S Singh, GK Schuurman-Wolters, HJ Wijma, ... Journal of the American Chemical Society 139 (51), 18640-18646, 2017 | 111 | 2017 |
| Computational library design for increasing haloalkane dehalogenase stability RJ Floor, HJ Wijma, DI Colpa, A Ramos‐Silva, PA Jekel, W Szymański, ... ChemBioChem 15 (11), 1660-1672, 2014 | 98 | 2014 |
| A random-sequential mechanism for nitrite binding and active site reduction in copper-containing nitrite reductase HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters Journal of Biological Chemistry 281 (24), 16340-16346, 2006 | 91 | 2006 |
| Computational design gains momentum in enzyme catalysis engineering HJ Wijma, DB Janssen The FEBS journal 280 (13), 2948-2960, 2013 | 86 | 2013 |
| A computational library design protocol for rapid improvement of protein stability: FRESCO HJ Wijma, MJLJ Fürst, DB Janssen Protein engineering: Methods and protocols, 69-85, 2017 | 85 | 2017 |
| Versatile peptide C-terminal functionalization via a computationally engineered peptide amidase B Wu, HJ Wijma, L Song, HJ Rozeboom, C Poloni, Y Tian, MI Arif, ... ACS Catalysis 6 (8), 5405-5414, 2016 | 82 | 2016 |
| Bidirectional catalysis by copper-containing nitrite reductase HJ Wijma, GW Canters, S de Vries, MP Verbeet Biochemistry 43 (32), 10467-10474, 2004 | 81 | 2004 |
| Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue HL van Beek, HJ Wijma, L Fromont, DB Janssen, MW Fraaije FEBS Open Bio 4, 168-174, 2014 | 78 | 2014 |
| Robust ω-transaminases by computational stabilization of the subunit interface Q Meng, N Capra, CM Palacio, E Lanfranchi, M Otzen, LZ Van Schie, ... ACS catalysis 10 (5), 2915-2928, 2020 | 77 | 2020 |
| Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks JGE van Leeuwen, HJ Wijma, RJ Floor, JM van der Laan, DB Janssen ChemBioChem 13 (1), 137-148, 2012 | 76 | 2012 |
| Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase M Schallmey, RJ Floor, B Hauer, M Breuer, PA Jekel, HJ Wijma, ... ChemBioChem 14 (7), 870-881, 2013 | 65 | 2013 |
| Computationally efficient and accurate enantioselectivity modeling by clusters of molecular dynamics simulations HJ Wijma, SJ Marrink, DB Janssen Journal of chemical information and modeling 54 (7), 2079-2092, 2014 | 63 | 2014 |
| A robust cosolvent-compatible halohydrin dehalogenase by computational library design H Arabnejad, M Dal Lago, PA Jekel, RJ Floor, AMWH Thunnissen, ... Protein Engineering, Design and Selection 30 (3), 175-189, 2017 | 62 | 2017 |
| Creating a more robust 5-hydroxymethylfurfural oxidase by combining computational predictions with a novel effective library design C Martin, A Ovalle Maqueo, HJ Wijma, MW Fraaije Biotechnology for Biofuels 11, 1-9, 2018 | 56 | 2018 |
| Protein film voltammetry of copper-containing nitrite reductase reveals reversible inactivation HJ Wijma, LJC Jeuken, MP Verbeet, FA Armstrong, GW Canters Journal of the American Chemical Society 129 (27), 8557-8565, 2007 | 53 | 2007 |
| Reconstitution of the type-1 active site of the H145G/A variants of nitrite reductase by ligand insertion HJ Wijma, MJ Boulanger, A Molon, M Fittipaldi, M Huber, MEP Murphy, ... Biochemistry 42 (14), 4075-4083, 2003 | 50 | 2003 |
Dick B. JanssenUniversity of GroningenPatvirtintas el. paštas rug.nl