| Towards design principles for determining the mechanical stability of proteins T Hoffmann, KM Tych, ML Hughes, DJ Brockwell, L Dougan Physical Chemistry Chemical Physics 15 (38), 15767-15780, 2013 | 83 | 2013 |
| Terahertz vibrational absorption spectroscopy using microstrip-line waveguides MB Byrne, J Cunningham, K Tych, AD Burnett, MR Stringer, CD Wood, ... Applied Physics Letters 93 (18), 2008 | 74 | 2008 |
| The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range H Girstmair, F Tippel, A Lopez, K Tych, F Stein, P Haberkant, ... Nature communications 10 (1), 3626, 2019 | 69 | 2019 |
| Terahertz pulsed spectroscopic imaging using optimized binary masks YC Shen, L Gan, M Stringer, A Burnett, K Tych, H Shen, JE Cunningham, ... Applied Physics Letters 95 (23), 2009 | 51 | 2009 |
| Folding and domain interactions of three orthologs of Hsp90 studied by single-molecule force spectroscopy M Jahn, K Tych, H Girstmair, M Steinmaßl, T Hugel, J Buchner, M Rief Structure 26 (1), 96-105. e4, 2018 | 47 | 2018 |
| Differential effects of hydrophobic core packing residues for thermodynamic and mechanical stability of a hyperthermophilic protein KM Tych, M Batchelor, T Hoffmann, MC Wilson, ML Hughes, E Paci, ... Langmuir 32 (29), 7392-7402, 2016 | 34 | 2016 |
| Single-molecule force spectroscopy identifies a small cold shock protein as being mechanically robust T Hoffmann, KM Tych, DJ Brockwell, L Dougan The Journal of Physical Chemistry B 117 (6), 1819-1826, 2013 | 33 | 2013 |
| Rapid and robust polyprotein production facilitates single-molecule mechanical characterization of β-barrel assembly machinery polypeptide transport associated domains T Hoffmann, KM Tych, T Crosskey, B Schiffrin, DJ Brockwell, L Dougan ACS nano 9 (9), 8811-8821, 2015 | 31 | 2015 |
| Single molecule force spectroscopy reveals the temperature-dependent robustness and malleability of a hyperthermophilic protein KM Tych, T Hoffmann, DJ Brockwell, L Dougan Soft Matter 9 (37), 9016-9025, 2013 | 25 | 2013 |
| Applying broadband terahertz time-domain spectroscopy to the analysis of crystalline proteins: a dehydration study KM Tych, AD Burnett, CD Wood, JE Cunningham, AR Pearson, ... Applied Crystallography 44 (1), 129-133, 2011 | 23 | 2011 |
| Perspective: a stirring role for metabolism in cells J Losa, S Leupold, D Alonso‐Martinez, P Vainikka, S Thallmair, KM Tych, ... Molecular systems biology 18 (4), e10822, 2022 | 21 | 2022 |
| Optimizing the calculation of energy landscape parameters from single-molecule protein unfolding experiments KM Tych, ML Hughes, J Bourke, Y Taniguchi, M Kawakami, DJ Brockwell, ... Physical Review E 91 (1), 012710, 2015 | 21 | 2015 |
| Nucleotide-dependent dimer association and dissociation of the chaperone Hsp90 KM Tych, M Jahn, F Gegenfurtner, VK Hechtl, J Buchner, T Hugel, M Rief The Journal of Physical Chemistry B 122 (49), 11373-11380, 2018 | 19 | 2018 |
| Tuning protein mechanics through an ionic cluster graft from an extremophilic protein KM Tych, M Batchelor, T Hoffmann, MC Wilson, E Paci, DJ Brockwell, ... Soft matter 12 (10), 2688-2699, 2016 | 17 | 2016 |
| Controlling amyloid fibril properties via ionic liquids: the representative case of ethylammonium nitrate and tetramethylguanidinium acetate on the amyloidogenesis of lysozyme VVS Pillai, P Kumari, S Kolagatla, V Garcia Sakai, S Rudić, BJ Rodriguez, ... The Journal of Physical Chemistry Letters 13 (30), 7058-7064, 2022 | 13 | 2022 |
| Bioconjugation strategies for connecting proteins to DNA-linkers for single-molecule force-based experiments LM van der Sleen, KM Tych Nanomaterials 11 (9), 2424, 2021 | 13 | 2021 |
| Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli TG Gaule, MA Smith, KM Tych, P Pirrat, CH Trinh, AR Pearson, ... Biochemistry 57 (36), 5301-5314, 2018 | 13 | 2018 |
| Measurement and analysis of the diffuse reflectance of powdered samples at terahertz frequencies using a quantum cascade laser P Dean, AD Burnett, K Tych, SP Khanna, M Lachab, JE Cunningham, ... The Journal of chemical physics 134 (13), 2011 | 12 | 2011 |
| Life in extreme environments: single molecule force spectroscopy as a tool to explore proteins from extremophilic organisms KM Tych, T Hoffmann, M Batchelor, ML Hughes, KE Kendrick, DL Walsh, ... Biochemical Society Transactions 43 (2), 179-185, 2015 | 11 | 2015 |
| A simple transfer-function-based approach for estimating material parameters from terahertz time-domain data KM Tych, CD Wood, W Tych IEEE Photonics Journal 6 (1), 1-11, 2013 | 10 | 2013 |
Lorna DouganProfessor of Physics, University of Leeds, School of Physics & AstronomyPatvirtintas el. paštas leeds.ac.uk