| Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 J Huo, A Le Bas, RR Ruza, HME Duyvesteyn, H Mikolajek, T Malinauskas, ... Nature structural & molecular biology 27 (9), 846-854, 2020 | 523 | 2020 |
| Neutralization of SARS-CoV-2 by destruction of the prefusion spike J Huo, Y Zhao, J Ren, D Zhou, HME Duyvesteyn, HM Ginn, L Carrique, ... Cell host & microbe 28 (3), 445-454. e6, 2020 | 394 | 2020 |
| Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient D Zhou, HME Duyvesteyn, CP Chen, CG Huang, TH Chen, SR Shih, ... Nature structural & molecular biology 27 (10), 950-958, 2020 | 312 | 2020 |
| Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels Z Fourati, RJ Howard, SA Heusser, H Hu, RR Ruza, L Sauguet, E Lindahl, ... Cell reports 23 (4), 993-1004, 2018 | 35 | 2018 |
| Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen BN Atkinson, D Steadman, Y Zhao, J Sipthorp, L Vecchia, RR Ruza, ... MedChemComm 10 (8), 1361-1369, 2019 | 28 | 2019 |
| Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State*♦ Z Fourati, RR Ruza, D Laverty, E Drège, S Delarue-Cochin, D Joseph, ... Journal of Biological Chemistry 292 (5), 1550-1558, 2017 | 22 | 2017 |
| 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment … W Mahy, NJ Willis, Y Zhao, HL Woodward, F Svensson, J Sipthorp, ... Journal of Medicinal Chemistry 63 (21), 12942-12956, 2020 | 20 | 2020 |
| Screening of a custom-designed acid fragment library identifies 1-phenylpyrroles and 1-phenylpyrrolidines as inhibitors of Notum carboxylesterase activity W Mahy, M Patel, D Steadman, HL Woodward, BN Atkinson, F Svensson, ... Journal of Medicinal Chemistry 63 (17), 9464-9483, 2020 | 18 | 2020 |
| The SARS-CoV-2 Spike harbours a lipid binding pocket which modulates stability of the prefusion trimer L Carrique, HME Duyvesteyn, T Malinauskas, Y Zhao, J Ren, D Zhou, ... BioRxiv, 2020.08. 13.249177, 2020 | 17 | 2020 |
| Mechanism of degrader-targeted protein ubiquitinability C Crowe, MA Nakasone, S Chandler, C Craigon, G Sathe, MH Tatham, ... Science Advances 10 (41), eado6492, 2024 | 12 | 2024 |
| Design of a potent, selective, and brain-penetrant inhibitor of wnt-deactivating enzyme notum by optimization of a crystallographic fragment hit NJ Willis, W Mahy, J Sipthorp, Y Zhao, HL Woodward, BN Atkinson, ... Journal of Medicinal Chemistry 65 (10), 7212-7230, 2022 | 11 | 2022 |
| Structural characterisation of a nanobody derived from a naïve library that neutralises SARS-CoV-2 J Huo, AL Bas, RR Ruza, HM Duyvesteyn, H Mikolajek, T Malinauskas, ... | 8 | 2020 |
| Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 J Huo, A Le Bas, RR Ruza, HME Duyvesteyn, H Mikolajek, T Malinauskas, ... Nature Structural & Molecular Biology 27 (11), 1094, 2020 | 6 | 2020 |
| Structural analysis and development of Notum fragment screening hits Y Zhao, W Mahy, NJ Willis, HL Woodward, D Steadman, ED Bayle, ... ACS chemical neuroscience 13 (13), 2060-2077, 2022 | 4 | 2022 |
| Author Correction: neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 J Huo, A Le Bas, RR Ruza, HME Duyvesteyn, H Mikolajek, T Malinauskas, ... Nature Structural & Molecular Biology 28 (3), 326, 2021 | 4 | 2021 |
| Structural insights into Frizzled3 through nanobody modulators J Hillier, Y Zhao, L Carrique, T Malinauskas, RR Ruza, TH Chang, G Yi, ... Nature Communications 15 (1), 7228, 2024 | 1 | 2024 |
| Structural Details of an Allosteric Mechanism for Bimodal Anesthetic Modulation of Pentameric Ligand-Gated Ion Channels RJ Howard, Z Fourati, SA Heusser, H Hu, RR Ruza, L Sauguet, E Lindahl, ... Biophysical Journal 114 (3), 204a, 2018 | 1 | 2018 |
| A pivot-tether model for nucleosome recognition by the chromosomal passenger complex RR Ruza, C Chung, D Gold, M Serena, E Roberts, ulrike gruneberg, ... bioRxiv, 2025.01. 22.634029, 2025 | | 2025 |
| Compounds which are inhibitors of Notum PV Fish, W Mahy, NJ Willis, H Woodward, BN Atkinson, ED Bayle, ... US Patent 11,634,391, 2023 | | 2023 |
| Structural analysis of Wnt signalling pathways RR Ruza University of Oxford, 2021 | | 2021 |
