| Reprogramming human T cell function and specificity with non-viral genome targeting TL Roth, C Puig-Saus, R Yu, E Shifrut, J Carnevale, PJ Li, J Hiatt, J Saco, ... Nature 559 (7714), 405-409, 2018 | 866 | 2018 |
| Genome-wide CRISPR screens in primary human T cells reveal key regulators of immune function E Shifrut, J Carnevale, V Tobin, TL Roth, JM Woo, CT Bui, PJ Li, ... Cell 175 (7), 1958-1971. e15, 2018 | 513 | 2018 |
| McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences N Tickotsky, T Sagiv, J Prilusky, E Shifrut, N Friedman Bioinformatics 33 (18), 2924-2929, 2017 | 452 | 2017 |
| CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging K Baruch, N Ron-Harel, H Gal, A Deczkowska, E Shifrut, W Ndifon, ... Proceedings of the national academy of sciences 110 (6), 2264-2269, 2013 | 339 | 2013 |
| Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, ... Nature biotechnology 38 (1), 44-49, 2020 | 283 | 2020 |
| Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence JA Belk, W Yao, N Ly, KA Freitas, YT Chen, Q Shi, AM Valencia, E Shifrut, ... Cancer cell 40 (7), 768-786. e7, 2022 | 218 | 2022 |
| T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity A Madi, E Shifrut, S Reich-Zeliger, H Gal, K Best, W Ndifon, B Chain, ... Genome research 24 (10), 1603-1612, 2014 | 205 | 2014 |
| CRISPR screen in regulatory T cells reveals modulators of Foxp3 JT Cortez, E Montauti, E Shifrut, J Gatchalian, Y Zhang, O Shaked, Y Xu, ... Nature 582 (7812), 416-420, 2020 | 199 | 2020 |
| Pooled knockin targeting for genome engineering of cellular immunotherapies TL Roth, PJ Li, F Blaeschke, JF Nies, R Apathy, C Mowery, R Yu, ... Cell 181 (3), 728-744. e21, 2020 | 186 | 2020 |
| T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences A Madi, A Poran, E Shifrut, S Reich-Zeliger, E Greenstein, I Zaretsky, ... Elife 6, e22057, 2017 | 157 | 2017 |
| High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails BR Shy, VS Vykunta, A Ha, A Talbot, TL Roth, DN Nguyen, WG Pfeifer, ... Nature biotechnology 41 (4), 521-531, 2023 | 139 | 2023 |
| Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence N Thomas, K Best, M Cinelli, S Reich-Zeliger, H Gal, E Shifrut, A Madi, ... Bioinformatics 30 (22), 3181-3188, 2014 | 130 | 2014 |
| Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells RT Leenay, A Aghazadeh, J Hiatt, D Tse, TL Roth, R Apathy, E Shifrut, ... Nature biotechnology 37 (9), 1034-1037, 2019 | 127 | 2019 |
| RASA2 ablation in T cells boosts antigen sensitivity and long-term function J Carnevale, E Shifrut, N Kale, WA Nyberg, F Blaeschke, YY Chen, Z Li, ... Nature 609 (7925), 174-182, 2022 | 123 | 2022 |
| Dynamic response diversity of NFAT isoforms in individual living cells N Yissachar, TS Fischler, AA Cohen, S Reich-Zeliger, D Russ, E Shifrut, ... Molecular cell 49 (2), 322-330, 2013 | 118 | 2013 |
| XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment Y Lee, D Bogdanoff, Y Wang, GC Hartoularos, JM Woo, CT Mowery, ... Science advances 7 (17), eabg4755, 2021 | 104 | 2021 |
| Chromatin conformation governs T-cell receptor Jβ gene segment usage W Ndifon, H Gal, E Shifrut, R Aharoni, N Yissachar, N Waysbort, ... Proceedings of the National Academy of Sciences 109 (39), 15865-15870, 2012 | 95 | 2012 |
| Monitoring the dynamics of primary T cell activation and differentiation using long term live cell imaging in microwell arrays I Zaretsky, M Polonsky, E Shifrut, S Reich-Zeliger, Y Antebi, G Aidelberg, ... Lab on a Chip 12 (23), 5007-5015, 2012 | 91 | 2012 |
| Functional CRISPR dissection of gene networks controlling human regulatory T cell identity K Schumann, SS Raju, M Lauber, S Kolb, E Shifrut, JT Cortez, N Skartsis, ... Nature immunology 21 (11), 1456-1466, 2020 | 80 | 2020 |
| Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire J Lu, F Van Laethem, A Bhattacharya, M Craveiro, I Saba, J Chu, NC Love, ... Nature communications 10 (1), 1019, 2019 | 77 | 2019 |