| antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences MH Medema, K Blin, P Cimermancic, V De Jager, P Zakrzewski, ... Nucleic acids research 39 (suppl_2), W339-W346, 2011 | 2210 | 2011 |
| antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters T Weber, K Blin, S Duddela, D Krug, HU Kim, R Bruccoleri, SY Lee, ... Nucleic acids research 43 (W1), W237-W243, 2015 | 2092 | 2015 |
| antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification K Blin, T Wolf, MG Chevrette, X Lu, CJ Schwalen, SA Kautsar, ... Nucleic acids research 45 (W1), W36-W41, 2017 | 1295 | 2017 |
| Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters P Cimermancic, MH Medema, J Claesen, K Kurita, LCW Brown, ... Cell 158 (2), 412-421, 2014 | 1046 | 2014 |
| antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers K Blin, MH Medema, D Kazempour, MA Fischbach, R Breitling, E Takano, ... Nucleic acids research 41 (W1), W204-W212, 2013 | 986 | 2013 |
| Minimum information about a biosynthetic gene cluster MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ... Nature chemical biology 11 (9), 625-631, 2015 | 934 | 2015 |
| Towards the sustainable discovery and development of new antibiotics M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ... Nature Reviews Chemistry 5 (10), 726-749, 2021 | 884 | 2021 |
| γ-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation E Takano Current opinion in microbiology 9 (3), 287-294, 2006 | 439 | 2006 |
| Detecting sequence homology at the gene cluster level with MultiGeneBlast MH Medema, E Takano, R Breitling Molecular biology and evolution 30 (5), 1218-1223, 2013 | 393 | 2013 |
| A complex role for the γ‐butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2) E Takano, R Chakraburtty, T Nihira, Y Yamada, MJ Bibb Molecular microbiology 41 (5), 1015-1028, 2001 | 286 | 2001 |
| Transcriptional regulation of the redD transcriptional activator gene accounts for growth‐phase‐dependent production of the antibiotic undecylprodigiosin in Streptomyces … E Takano, HC Gramajo, E Strauch, N Andres, J White, MJ Bibb Molecular microbiology 6 (19), 2797-2804, 1992 | 271 | 1992 |
| Stationary‐phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated HC Gramajo, E Takano, MJ Bibb Molecular microbiology 7 (6), 837-845, 1993 | 268 | 1993 |
| Computational tools for the synthetic design of biochemical pathways MH Medema, R Van Raaphorst, E Takano, R Breitling Nature Reviews Microbiology 10 (3), 191-202, 2012 | 264 | 2012 |
| An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals P Carbonell, AJ Jervis, CJ Robinson, C Yan, M Dunstan, N Swainston, ... Communications biology 1 (1), 66, 2018 | 257 | 2018 |
| The stringent response in Streptomyces coelicolor A3(2) E Strauch, E Takano, HA Baylts, MJ Bibb Molecular microbiology 5 (2), 289-298, 1991 | 253 | 1991 |
| The sequence of a 1.8-Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways MH Medema, A Trefzer, A Kovalchuk, M Van Den Berg, U Müller, ... Genome Biology and Evolution 2, 212-224, 2010 | 248 | 2010 |
| A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis MH Medema, P Cimermancic, A Sali, E Takano, MA Fischbach PLoS computational biology 10 (12), e1004016, 2014 | 237 | 2014 |
| Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms MH Medema, R Breitling, R Bovenberg, E Takano Nature Reviews Microbiology 9 (2), 131-137, 2011 | 223 | 2011 |
| Purification and Structural Determination of SCB1, a γ-Butyrolactone That Elicits Antibiotic Production inStreptomyces coelicolor A3 (2) E Takano, T Nihira, Y Hara, JJ Jones, CJL Gershater, Y Yamada, M Bibb Journal of Biological Chemistry 275 (15), 11010-11016, 2000 | 219 | 2000 |
| The dynamic architecture of the metabolic switch in Streptomyces coelicolor K Nieselt, F Battke, A Herbig, P Bruheim, A Wentzel, ØM Jakobsen, ... BMC genomics 11 (1), 10, 2010 | 212 | 2010 |
Rainer BreitlingProfessor of Systems Biology, Manchester Institute of Biotechnology, University of ManchesterPatvirtintas el. paštas manchester.ac.uk
