| Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques RM Koffie, M Meyer-Luehmann, T Hashimoto, KW Adams, ML Mielke, ... Proceedings of the National Academy of Sciences 106 (10), 4012-4017, 2009 | 1029 | 2009 |
| The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system HC Tai, A Serrano-Pozo, T Hashimoto, MP Frosch, TL Spires-Jones, ... The American journal of pathology 181 (4), 1426-1435, 2012 | 508 | 2012 |
| Amyloid β induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation HY Wu, E Hudry, T Hashimoto, K Kuchibhotla, A Rozkalne, Z Fan, ... Journal of Neuroscience 30 (7), 2636-2649, 2010 | 431 | 2010 |
| Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity KM Danzer, WP Ruf, P Putcha, D Joyner, T Hashimoto, C Glabe, ... The FASEB journal 25 (1), 326, 2011 | 383 | 2011 |
| Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β RM Koffie, T Hashimoto, HC Tai, KR Kay, A Serrano-Pozo, D Joyner, ... Brain 135 (7), 2155-2168, 2012 | 378 | 2012 |
| Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide T Hashimoto, A Serrano-Pozo, Y Hori, KW Adams, S Takeda, AO Banerji, ... Journal of Neuroscience 32 (43), 15181-15192, 2012 | 366 | 2012 |
| CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC‐P/collagen type XXV T Hashimoto, T Wakabayashi, A Watanabe, H Kowa, R Hosoda, ... The EMBO journal, 2002 | 266 | 2002 |
| Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease K Yamamoto, Z Tanei, T Hashimoto, T Wakabayashi, H Okuno, Y Naka, ... Cell reports 11 (6), 859-865, 2015 | 257 | 2015 |
| Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease B DaRocha-Souto, M Coma, BG Perez-Nievas, TC Scotton, M Siao, ... Neurobiology of disease 45 (1), 425-437, 2012 | 217 | 2012 |
| Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain E Hudry, J Dashkoff, AD Roe, S Takeda, RM Koffie, T Hashimoto, ... Science translational medicine 5 (212), 212ra161-212ra161, 2013 | 206 | 2013 |
| Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer’s disease Y Wakutani, K Watanabe, Y Adachi, K Wada-Isoe, K Urakami, H Ninomiya, ... Journal of Neurology, Neurosurgery & Psychiatry 75 (7), 1039-1042, 2004 | 189 | 2004 |
| Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice B DaRocha-Souto, TC Scotton, M Coma, A Serrano-Pozo, T Hashimoto, ... Journal of Neuropathology & Experimental Neurology 70 (5), 360-376, 2011 | 183 | 2011 |
| Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain M Arbel-Ornath, E Hudry, JR Boivin, T Hashimoto, S Takeda, ... Molecular neurodegeneration 12, 1-14, 2017 | 180 | 2017 |
| Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS‐1 mutations that lead to exceptionally high amyloid‐β concentrations H Houlden, M Baker, E McGowan, P Lewis, M Hutton, R Crook, NW Wood, ... Annals of neurology 48 (5), 806-808, 2000 | 179 | 2000 |
| Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration K Ishida, K Yamada, R Nishiyama, T Hashimoto, I Nishida, Y Abe, ... Journal of Experimental Medicine 219 (3), 2022 | 173 | 2022 |
| The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells K Yamada, T Hashimoto, C Yabuki, Y Nagae, M Tachikawa, DK Strickland, ... Journal of Biological Chemistry 283 (50), 34554-34562, 2008 | 147 | 2008 |
| Aβ immunotherapy: intracerebral sequestration of Aβ by an anti-Aβ monoclonal antibody 266 with high affinity to soluble Aβ K Yamada, C Yabuki, P Seubert, D Schenk, Y Hori, S Ohtsuki, T Terasaki, ... Journal of Neuroscience 29 (36), 11393-11398, 2009 | 145 | 2009 |
| The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Aβ fibril formation without increasing protofibril formation Y Hori, T Hashimoto, Y Wakutani, K Urakami, K Nakashima, MM Condron, ... Journal of biological chemistry 282 (7), 4916-4923, 2007 | 143 | 2007 |
| Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver C Tamaki, S Ohtsuki, T Iwatsubo, T Hashimoto, K Yamada, C Yabuki, ... Pharmaceutical research 23, 1407-1416, 2006 | 141 | 2006 |
| Inhibition of the NFAT pathway alleviates amyloid beta neurotoxicity in a mouse model of Alzheimer's disease E Hudry, HY Wu, M Arbel-Ornath, T Hashimoto, R Matsouaka, Z Fan, ... Journal of Neuroscience 32 (9), 3176-3192, 2012 | 126 | 2012 |
