Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk M Turner, P Joseph Mee, PS Costello, O Williams, AA Price, LP Duddy, ... Nature 378 (6554), 298-302, 1995 | 929 | 1995 |
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. JM Oliver, DL Burg, BS Wilson, JL McLaughlin, RL Geahlen Journal of Biological Chemistry 269 (47), 29697-29703, 1994 | 424 | 1994 |
Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. JE Hutchcroft, ML Harrison, RL Geahlen Journal of Biological Chemistry 267 (12), 8613-8619, 1992 | 365 | 1992 |
Kinase inhibitors from Polygonum cuspidatum GS Jayatilake, H Jayasuriya, ES Lee, NM Koonchanok, RL Geahlen, ... Journal of Natural Products 56 (10), 1805-1810, 1993 | 348 | 1993 |
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. JE Hutchcroft, RL Geahlen, GG Deanin, JM Oliver Proceedings of the National Academy of Sciences 89 (19), 9107-9111, 1992 | 292 | 1992 |
Cloning and expression of a protein-tyrosine-phosphatase. KL Guan, RS Haun, SJ Watson, RL Geahlen, JE Dixon Proceedings of the National Academy of Sciences 87 (4), 1501-1505, 1990 | 291 | 1990 |
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum H Jayasuriya, NM Koonchanok, RL Geahlen, JL McLaughlin, CJ Chang Journal of Natural Products 55 (5), 696-698, 1992 | 276 | 1992 |
Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves YM Efremov, WH Wang, SD Hardy, RL Geahlen, A Raman Scientific reports 7 (1), 1541, 2017 | 270 | 2017 |
Piceatannol (3, 4, 3′, 5′-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor RL Geahlen, JL McLaughlin Biochemical and biophysical research communications 165 (1), 241-245, 1989 | 267 | 1989 |
DAP12-mediated signal transduction in natural killer cells: a dominant role for the Syk protein-tyrosine kinase DW McVicar, LS Taylor, P Gosselin, J Willette-Brown, AI Mikhael, ... Journal of Biological Chemistry 273 (49), 32934-32942, 1998 | 261 | 1998 |
Mechanisms of p34cdc2 Regulation S Atherton-Fessler, LL Parker, RL Geahlen, H Piwnica-Worms Molecular and cellular biology 13 (3), 1675-1685, 1993 | 260 | 1993 |
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. SJ Corey, AL Burkhardt, JB Bolen, RL Geahlen, LS Tkatch, DJ Tweardy Proceedings of the National Academy of Sciences 91 (11), 4683-4687, 1994 | 255 | 1994 |
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogs M Cushman, D Nagarathnam, DL Burg, RL Geahlen Journal of medicinal chemistry 34 (2), 798-806, 1991 | 247 | 1991 |
CD22 associates with the human surface IgM-B-cell antigen receptor complex. C Leprince, KE Draves, RL Geahlen, JA Ledbetter, EA Clark Proceedings of the National Academy of Sciences 90 (8), 3236-3240, 1993 | 243 | 1993 |
Getting Syk: spleen tyrosine kinase as a therapeutic target RL Geahlen Trends in pharmacological sciences 35 (8), 414-422, 2014 | 241 | 2014 |
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase JE Hutchcroft, ML Harrison, RL Geahlen Journal of Biological Chemistry 266 (23), 14846-14849, 1991 | 234 | 1991 |
Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogs of piceatannol K Thakkar, RL Geahlen, M Cushman Journal of medicinal chemistry 36 (20), 2950-2955, 1993 | 229 | 1993 |
Syk and pTyr'd: Signaling through the B cell antigen receptor RL Geahlen Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1793 (7), 1115-1127, 2009 | 228 | 2009 |
Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis ML Harrison, P Rathinavelu, P Arese, RL Geahlen, PS Low Journal of biological chemistry 266 (7), 4106-4111, 1991 | 226 | 1991 |
Reversible palmitoylation of the protein-tyrosine kinase p56lck. LA Paige, MJ Nadler, ML Harrison, JM Cassady, RL Geahlen Journal of Biological Chemistry 268 (12), 8669-8674, 1993 | 211 | 1993 |