One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering H Wang, H Yang, CS Shivalila, MM Dawlaty, AW Cheng, F Zhang, ... cell 153 (4), 910-918, 2013 | 4453 | 2013 |
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering H Yang, H Wang, CS Shivalila, AW Cheng, L Shi, R Jaenisch Cell 154 (6), 1370-1379, 2013 | 1998 | 2013 |
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes TP Gu, F Guo, H Yang, HP Wu, GF Xu, W Liu, ZG Xie, L Shi, X He, S Jin, ... Nature 477 (7366), 606-610, 2011 | 1343 | 2011 |
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system AW Cheng, H Wang, H Yang, L Shi, Y Katz, TW Theunissen, ... Cell research 23 (10), 1163-1171, 2013 | 1012 | 2013 |
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos E Zuo, Y Sun, W Wei, T Yuan, W Ying, H Sun, L Yuan, LM Steinmetz, Y Li, ... Science 364 (6437), 289-292, 2019 | 787 | 2019 |
Generating genetically modified mice using CRISPR/Cas-mediated genome engineering H Yang, H Wang, R Jaenisch Nature protocols 9 (8), 1956-1968, 2014 | 621 | 2014 |
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis C Zhou, Y Sun, R Yan, Y Liu, E Zuo, C Gu, L Han, Y Wei, X Hu, R Zeng, ... Nature 571 (7764), 275-278, 2019 | 465 | 2019 |
Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice H Zhou, J Su, X Hu, C Zhou, H Li, Z Chen, Q Xiao, BO Wang, W Wu, ... Cell 181 (3), 590-603. e16, 2020 | 396 | 2020 |
Homology-mediated end joining-based targeted integration using CRISPR/Cas9 X Yao, X Wang, X Hu, Z Liu, J Liu, H Zhou, X Shen, Y Wei, Z Huang, ... Cell research 27 (6), 801-814, 2017 | 336 | 2017 |
In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice H Zhou, J Liu, C Zhou, N Gao, Z Rao, H Li, X Hu, C Li, X Yao, X Shen, ... Nature neuroscience 21 (3), 440-446, 2018 | 288 | 2018 |
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes C Xu, Y Zhou, Q Xiao, B He, G Geng, Z Wang, B Cao, X Dong, W Bai, ... Nature methods 18 (5), 499-506, 2021 | 268 | 2021 |
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells H Yang, L Shi, BA Wang, D Liang, C Zhong, W Liu, Y Nie, J Liu, J Zhao, ... Cell 149 (3), 605-617, 2012 | 245 | 2012 |
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs E Zuo, YJ Cai, K Li, Y Wei, BA Wang, Y Sun, Z Liu, J Liu, X Hu, W Wei, ... Cell research 27 (7), 933-945, 2017 | 221 | 2017 |
CRISPR/Cas9-mediated targeted chromosome elimination E Zuo, X Huo, X Yao, X Hu, Y Sun, J Yin, B He, X Wang, L Shi, J Ping, ... Genome biology 18, 1-18, 2017 | 207 | 2017 |
Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation J Jiang, W Lv, X Ye, L Wang, M Zhang, H Yang, M Okuka, C Zhou, ... Cell research 23 (1), 92-106, 2013 | 170 | 2013 |
Tild-CRISPR allows for efficient and precise gene knockin in mouse and human cells X Yao, M Zhang, X Wang, W Ying, X Hu, P Dai, F Meng, L Shi, Y Sun, ... Developmental cell 45 (4), 526-536. e5, 2018 | 150 | 2018 |
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes H Yang, Z Liu, Y Ma, C Zhong, Q Yin, C Zhou, L Shi, Y Cai, H Zhao, ... Cell research 23 (10), 1187-1200, 2013 | 146 | 2013 |
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects H Tong, J Huang, Q Xiao, B He, X Dong, Y Liu, X Yang, D Han, Z Wang, ... Nature biotechnology 41 (1), 108-119, 2023 | 145 | 2023 |
Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice S Ling, S Yang, X Hu, D Yin, Y Dai, X Qian, D Wang, X Pan, J Hong, ... Nature biomedical engineering 5 (2), 144-156, 2021 | 145 | 2021 |
A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects E Zuo, Y Sun, T Yuan, B He, C Zhou, W Ying, J Liu, W Wei, R Zeng, Y Li, ... Nature methods 17 (6), 600-604, 2020 | 133 | 2020 |