| PROTAC targeted protein degraders: the past is prologue M Békés, DR Langley, CM Crews Nature reviews Drug discovery 21 (3), 181-200, 2022 | 1842 | 2022 |
| Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect M Gao, RE Nettles, M Belema, LB Snyder, VN Nguyen, RA Fridell, ... Nature 465 (7294), 96-100, 2010 | 1141 | 2010 |
| Selective interactions of cationic porphyrins with G-quadruplex structures H Han, DR Langley, A Rangan, LH Hurley Journal of the American Chemical Society 123 (37), 8902-8913, 2001 | 435 | 2001 |
| Inhibition of hepatitis B virus polymerase by entecavir DR Langley, AW Walsh, CJ Baldick, BJ Eggers, RE Rose, SM Levine, ... Journal of virology 81 (8), 3992-4001, 2007 | 240 | 2007 |
| Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions Q Guo, HT Ho, I Dicker, L Fan, N Zhou, J Friborg, T Wang, BV McAuliffe, ... Journal of virology 77 (19), 10528-10536, 2003 | 225 | 2003 |
| Pyrrolo [1, 4] benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds LH Hurley, T Reck, DE Thurston, DR Langley, KG Holden, RP Hertzberg, ... Chemical research in toxicology 1 (5), 258-268, 1988 | 214 | 1988 |
| Geen titel WO Patent 2008021927:A2, 0 | 188* | |
| A versatile and efficient synthesis of carbinolamine-containing pyrrolo [1, 4] benzodiazepines via the cyclization of N-(2-aminobenzoyl) pyrrolidine-2-carboxaldehyde diethyl … DR Langley, DE Thurston The Journal of Organic Chemistry 52 (1), 91-97, 1987 | 185 | 1987 |
| Compounds useful as immunomodulators LS Chupak, X Zheng | 159 | 2015 |
| Macrocyclic inhibitors of the PD-1/PD-L1 and CD80 (B7-1)/PD-L1 protein/protein interactions MM Miller, C Mapelli, MP Allen, MS Bowsher, KM Boy, EP Gillis, ... US Patent 9,308,236, 2016 | 157 | 2016 |
| Inhibitors of HIV-1 attachment: the discovery and development of temsavir and its prodrug fostemsavir NA Meanwell, MR Krystal, B Nowicka-Sans, DR Langley, DA Conlon, ... Journal of medicinal chemistry 61 (1), 62-80, 2018 | 147 | 2018 |
| Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers SW Gerritz, C Cianci, S Kim, BC Pearce, C Deminie, L Discotto, ... Proceedings of the National Academy of Sciences 108 (37), 15366-15371, 2011 | 145 | 2011 |
| Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529 M Pancera, YT Lai, T Bylund, A Druz, S Narpala, S O'Dell, A Schön, ... Nature chemical biology 13 (10), 1115-1122, 2017 | 144 | 2017 |
| Chemistry and structure elucidation of the kedarcidin chromophore JE Leet, DR Schroeder, DR Langley, KL Colson, S Huang, SE Klohr, ... Journal of the American Chemical Society 115 (18), 8432-8443, 1993 | 142 | 1993 |
| Molecular dynamic simulations of environment and sequence dependent DNA conformations: the development of the BMS nucleic acid force field and comparison with experimental results DR Langley Journal of Biomolecular Structure and Dynamics 16 (3), 487-509, 1998 | 140 | 1998 |
| A general amino acid synthesis enabled by innate radical cross‐coupling S Ni, AF Garrido‐Castro, RR Merchant, JN de Gruyter, DC Schmitt, ... Angewandte Chemie 130 (44), 14768-14773, 2018 | 139 | 2018 |
| Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusion C Cianci, DR Langley, DD Dischino, Y Sun, KL Yu, A Stanley, J Roach, ... Proceedings of the National Academy of Sciences 101 (42), 15046-15051, 2004 | 128 | 2004 |
| The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors SM Lambert, DR Langley, JA Garnett, R Angell, K Hedgethorne, ... Protein Science 23 (6), 723-734, 2014 | 119 | 2014 |
| Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development MD Wittman, JM Carboni, Z Yang, FY Lee, M Antman, R Attar, P Balimane, ... Journal of medicinal chemistry 52 (23), 7360-7363, 2009 | 118 | 2009 |
| Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core P Sivaprakasam, X Han, RL Civiello, S Jacutin-Porte, K Kish, M Pokross, ... Bioorganic & medicinal chemistry letters 25 (9), 1856-1863, 2015 | 114 | 2015 |
