| Macrocyclic drugs and synthetic methodologies toward macrocycles X Yu, D Sun Molecules 18 (6), 6230-6268, 2013 | 276 | 2013 |
| Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism AJ Bott, J Shen, C Tonelli, L Zhan, N Sivaram, YP Jiang, X Yu, V Bhatt, ... Cell reports 29 (5), 1287-1298. e6, 2019 | 155 | 2019 |
| Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders M Cheng, X Yu, K Lu, L Xie, L Wang, F Meng, X Han, X Chen, J Liu, ... Journal of Medicinal Chemistry 63 (3), 1216-1232, 2020 | 151 | 2020 |
| EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis J Wang, X Yu, W Gong, X Liu, KS Park, A Ma, YH Tsai, Y Shen, T Onikubo, ... Nature cell biology 24 (3), 384-399, 2022 | 134 | 2022 |
| A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ... Science translational medicine 13 (613), eabj1578, 2021 | 103 | 2021 |
| Discovery of first-in-class protein arginine methyltransferase 5 (PRMT5) degraders Y Shen, G Gao, X Yu, H Kim, L Wang, L Xie, M Schwarz, X Chen, ... Journal of medicinal chemistry 63 (17), 9977-9989, 2020 | 84 | 2020 |
| Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery AM Chiarella, KV Butler, BE Gryder, D Lu, TA Wang, X Yu, S Pomella, ... Nature biotechnology 38 (1), 50-55, 2020 | 77 | 2020 |
| Cationic Palladium Complex Catalyzed Diastereo-and Enantioselective Tandem Annulation of 2-Formylarylboronic Acids with Allenoates X Yu, X Lu Organic Letters 11 (19), 4366-4369, 2009 | 57 | 2009 |
| AKT degradation selectively inhibits the growth of PI3K/PTEN pathway–mutant cancers with wild-type KRAS and BRAF by destabilizing aurora kinase B J Xu, X Yu, TC Martin, A Bansal, K Cheung, A Lubin, E Stratikopoulos, ... Cancer discovery 11 (12), 3064-3089, 2021 | 51 | 2021 |
| Design, synthesis, and evaluation of potent, selective, and bioavailable AKT kinase degraders X Yu, J Xu, L Xie, L Wang, Y Shen, KM Cahuzac, X Chen, J Liu, ... Journal of medicinal chemistry 64 (24), 18054-18081, 2021 | 42 | 2021 |
| Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization MP Schwalm, A Krämer, A Dölle, J Weckesser, X Yu, J Jin, K Saxena, ... Cell chemical biology 30 (7), 753-765. e8, 2023 | 41 | 2023 |
| ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism J Li, PM Galbo Jr, W Gong, AJ Storey, YH Tsai, X Yu, JH Ahn, Y Guo, ... Nature communications 12 (1), 1045, 2021 | 39 | 2021 |
| TF-DUBTACs stabilize tumor suppressor transcription factors J Liu, X Yu, H Chen, HU Kaniskan, L Xie, X Chen, J Jin, W Wei Journal of the American Chemical Society 144 (28), 12934-12941, 2022 | 38 | 2022 |
| Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic D Li, X Yu, J Kottur, W Gong, Z Zhang, AJ Storey, YH Tsai, H Uryu, Y Shen, ... Oncogene 41 (24), 3328-3340, 2022 | 37 | 2022 |
| Discovery of potent, selective, and in vivo efficacious AKT kinase protein degraders via structure–activity relationship studies X Yu, J Xu, Y Shen, KM Cahuzac, K Park, B Dale, J Liu, RE Parsons, J Jin Journal of medicinal chemistry 65 (4), 3644-3666, 2022 | 35 | 2022 |
| Cationic palladium-catalyzed [5+ 2] annulation of 2-acylmethoxyarylboronic acids and allenoates: synthesis of 1-benzoxepine derivatives X Yu, X Lu The Journal of Organic Chemistry 76 (15), 6350-6355, 2011 | 35 | 2011 |
| Efficient Synthesis of 9‐Tosylaminofluorene Derivatives by Boron Trifluoride Etherate‐Catalyzed Aza‐Friedel–Crafts Reaction of in situ Generated N‐Tosylbenzaldimines X Yu, X Lu Advanced Synthesis & Catalysis 353 (4), 569-574, 2011 | 34 | 2011 |
| Targeting triple-negative breast cancer by a novel proteolysis targeting chimera degrader of enhancer of zeste homolog 2 B Dale, C Anderson, KS Park, HU Kaniskan, A Ma, Y Shen, C Zhang, ... ACS Pharmacology & Translational Science 5 (7), 491-507, 2022 | 32 | 2022 |
| Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors X Yu, EJ Park, TP Kondratyuk, JM Pezzuto, D Sun Organic & biomolecular chemistry 10 (44), 8835-8847, 2012 | 31 | 2012 |
| Design, synthesis, and characterization of ogerin-based positive allosteric modulators for G protein-coupled receptor 68 (GPR68) X Yu, XP Huang, TP Kenakin, ST Slocum, X Chen, ML Martini, J Liu, J Jin Journal of medicinal chemistry 62 (16), 7557-7574, 2019 | 29 | 2019 |
Jian JinProfessor, Department of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiGeverifieerd e-mailadres voor mssm.edu
