| Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway JM Han, SJ Jeong, MC Park, G Kim, NH Kwon, HK Kim, SH Ha, SH Ryu, ... Cell 149 (2), 410-424, 2012 | 890 | 2012 |
| Glutamine reliance in cell metabolism HC Yoo, YC Yu, Y Sung, JM Han Experimental & molecular medicine 52 (9), 1496-1516, 2020 | 736 | 2020 |
| A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells HC Yoo, SJ Park, M Nam, J Kang, K Kim, JH Yeo, JK Kim, Y Heo, HS Lee, ... Cell metabolism 31 (2), 267-283. e12, 2020 | 355 | 2020 |
| Somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia JS Lim, R Gopalappa, SH Kim, S Ramakrishna, M Lee, W Kim, J Kim, ... The American Journal of Human Genetics 100 (3), 454-472, 2017 | 213 | 2017 |
| Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation MJ Kim, BJ Park, YS Kang, HJ Kim, JH Park, JW Kang, SW Lee, JM Han, ... Nature genetics 34 (3), 330-336, 2003 | 213 | 2003 |
| LysRS serves as a key signaling molecule in the immune response by regulating gene expression N Yannay-Cohen, I Carmi-Levy, G Kay, CM Yang, JM Han, DM Kemeny, ... Molecular cell 34 (5), 603-611, 2009 | 181 | 2009 |
| Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis MC Park, T Kang, D Jin, JM Han, SB Kim, YJ Park, K Cho, YW Park, ... Proceedings of the National Academy of Sciences 109 (11), E640-E647, 2012 | 168 | 2012 |
| Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3 NH Kwon, T Kang, JY Lee, HH Kim, HR Kim, J Hong, YS Oh, JM Han, ... Proceedings of the National Academy of Sciences 108 (49), 19635-19640, 2011 | 138 | 2011 |
| Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA JH Kim, S Do Lee, JM Han, TG Lee, Y Kim, JB Park, JD Lambeth, PG Suh, ... FEBS letters 430 (3), 231-235, 1998 | 138 | 1998 |
| AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53 JM Han, BJ Park, SG Park, YS Oh, SJ Choi, SW Lee, SK Hwang, ... Proceedings of the National Academy of Sciences 105 (32), 11206-11211, 2008 | 137 | 2008 |
| Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis JW Choi, DG Kim, AE Lee, HR Kim, JY Lee, NH Kwon, YK Shin, ... PLoS genetics 7 (3), e1001351, 2011 | 120 | 2011 |
| Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling G Du, YM Altshuller, Y Kim, JM Han, SH Ryu, AJ Morris, MA Frohman Molecular biology of the cell 11 (12), 4359-4368, 2000 | 113 | 2000 |
| Phospholipase D1 is phosphorylated and activated by protein kinase C in caveolin-enriched microdomains within the plasma membrane Y Kim, JM Han, BR Han, KA Lee, JH Kim, BD Lee, IH Jang, PG Suh, ... Journal of Biological Chemistry 275 (18), 13621-13627, 2000 | 103 | 2000 |
| Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites Y Kim, JM Han, JB Park, SD Lee, YS Oh, C Chung, TG Lee, JH Kim, ... Biochemistry 38 (32), 10344-10351, 1999 | 96 | 1999 |
| Hierarchical network between the components of the multi-tRNA synthetase complex: implications for complex formation JM Han, MJ Lee, SG Park, SH Lee, E Razin, EC Choi, S Kim Journal of Biological Chemistry 281 (50), 38663-38667, 2006 | 91 | 2006 |
| Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction JH Kim, C Lee, M Lee, H Wang, K Kim, SJ Park, I Yoon, J Jang, H Zhao, ... Nature communications 8 (1), 732, 2017 | 89 | 2017 |
| Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling MS Yoon, K Son, E Arauz, JM Han, S Kim, J Chen Cell reports 16 (6), 1510-1517, 2016 | 89 | 2016 |
| Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway M Lee, JH Kim, I Yoon, C Lee, M Fallahi Sichani, JS Kang, J Kang, M Guo, ... Proceedings of the National Academy of Sciences 115 (23), E5279-E5288, 2018 | 88 | 2018 |
| AIMP2 promotes TNFα-dependent apoptosis via ubiquitin-mediated degradation of TRAF2 JW Choi, DG Kim, MC Park, JY Um, JM Han, SG Park, EC Choi, S Kim Journal of cell science 122 (15), 2710-2715, 2009 | 85 | 2009 |
| Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 I Yoon, M Nam, HK Kim, HS Moon, S Kim, J Jang, JA Song, SJ Jeong, ... Science 367 (6474), 205-210, 2020 | 83 | 2020 |
Sunghoon KimDirector of Medicinal Bioconvergence Research Center, Professor of College of Pharmacy, SeoulGeverifieerd e-mailadres voor snu.ac.kr