| The future of peptide‐based drugs DJ Craik, DP Fairlie, S Liras, D Price Chemical biology & drug design 81 (1), 136-147, 2013 | 2269 | 2013 |
| On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds TR White, CM Renzelman, AC Rand, T Rezai, CM McEwen, VM Gelev, ... Nature chemical biology 7 (11), 810-817, 2011 | 421 | 2011 |
| Enantioselective intramolecular cyclopropanations of allylic and homoallylic diazoacetates and diazoacetamides using chiral dirhodium (II) carboxamide catalysts MP Doyle, RE Austin, AS Bailey, MP Dwyer, AB Dyatkin, AV Kalinin, ... Journal of the American Chemical Society 117 (21), 5763-5775, 1995 | 303 | 1995 |
| Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl … PR Verhoest, DS Chapin, M Corman, K Fonseca, JF Harms, X Hou, ... Journal of medicinal chemistry 52 (16), 5188-5196, 2009 | 249 | 2009 |
| Comparative α‐Helicity of cyclic pentapeptides in water AD De Araujo, HN Hoang, WM Kok, F Diness, P Gupta, TA Hill, RW Driver, ... Angewandte Chemie International Edition 53 (27), 6965-6969, 2014 | 202 | 2014 |
| Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients CK Wang, SE Northfield, B Colless, S Chaousis, I Hamernig, RJ Lohman, ... Proceedings of the National Academy of Sciences 111 (49), 17504-17509, 2014 | 169 | 2014 |
| Receptor-mediated delivery of CRISPR-Cas9 endonuclease for cell-type-specific gene editing R Rouet, BA Thuma, MD Roy, NG Lintner, DM Rubitski, JE Finley, ... Journal of the American Chemical Society 140 (21), 6596-6603, 2018 | 168 | 2018 |
| Probing the physicochemical boundaries of cell permeability and oral bioavailability in lipophilic macrocycles inspired by natural products AT Bockus, KW Lexa, CR Pye, AS Kalgutkar, JW Gardner, KCR Hund, ... Journal of Medicinal Chemistry 58 (11), 4581-4589, 2015 | 158 | 2015 |
| Improving on nature: making a cyclic heptapeptide orally bioavailable DS Nielsen, HN Hoang, RJ Lohman, TA Hill, AJ Lucke, DJ Craik, ... Angewandte Chemie International Edition 53 (45), 12059-12063, 2014 | 158 | 2014 |
| A mild method for the preparation of 1, 3, 4-oxadiazoles: Triflic anhydride promoted cyclization of diacylhydrazines S Liras, MP Allen, BE Segelstein Synthetic Communications 30 (3), 437-443, 2000 | 153 | 2000 |
| Nonclassical size dependence of permeation defines bounds for passive adsorption of large drug molecules CR Pye, WM Hewitt, J Schwochert, TD Haddad, CE Townsend, L Etienne, ... Journal of medicinal chemistry 60 (5), 1665-1672, 2017 | 147 | 2017 |
| Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance AC Rand, SSF Leung, H Eng, CJ Rotter, R Sharma, AS Kalgutkar, ... MedChemComm 3 (10), 1282-1289, 2012 | 145 | 2012 |
| Discovery of a series of 6, 7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors TA Chappie, JM Humphrey, MP Allen, KG Estep, CB Fox, LA Lebel, ... Journal of medicinal chemistry 50 (2), 182-185, 2007 | 145 | 2007 |
| Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain NG Lintner, KF McClure, D Petersen, AT Londregan, DW Piotrowski, ... PLoS biology 15 (3), e2001882, 2017 | 138 | 2017 |
| Fmoc-based synthesis of disulfide-rich cyclic peptides O Cheneval, CI Schroeder, T Durek, P Walsh, YH Huang, S Liras, ... The Journal of organic chemistry 79 (12), 5538-5544, 2014 | 138 | 2014 |
| Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical … JA Pfefferkorn, A Guzman-Perez, J Litchfield, R Aiello, JL Treadway, ... Journal of medicinal chemistry 55 (3), 1318-1333, 2012 | 135 | 2012 |
| Use of 3D properties to characterize beyond rule-of-5 property space for passive permeation CRW Guimarães, AM Mathiowetz, M Shalaeva, G Goetz, S Liras Journal of chemical information and modeling 52 (4), 882-890, 2012 | 126 | 2012 |
| Enantio-and diastereoselectivity in the intramolecular cyclopropanation of secondary allylic diazoacetates SF Martin, MR Spaller, S Liras, B Hartmann Journal of the American Chemical Society 116 (10), 4493-4494, 1994 | 126 | 1994 |
| Applications of Vinylogous Mannich Reactions. Total Syntheses of the Ergot Alkaloids Rugulovasines A and B and Setoclavine S Liras, CL Lynch, AM Fryer, BT Vu, SF Martin Journal of the American Chemical Society 123 (25), 5918-5924, 2001 | 122 | 2001 |
| Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor CA Sanhueza, MM Baksh, B Thuma, MD Roy, S Dutta, C Préville, ... Journal of the American Chemical Society 139 (9), 3528-3536, 2017 | 111 | 2017 |
David P FairlieProfessor, University of Queensland, Brisbane, AustraliaGeverifieerd e-mailadres voor imb.uq.edu.au