Bacterial proteases, untapped antimicrobial drug targets E Culp, GD Wright The Journal of antibiotics 70 (4), 366-377, 2017 | 270 | 2017 |
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling EJ Culp, N Waglechner, W Wang, AA Fiebig-Comyn, YP Hsu, K Koteva, ... Nature 578 (7796), 582-587, 2020 | 263 | 2020 |
Cross-feeding in the gut microbiome: ecology and mechanisms EJ Culp, AL Goodman Cell Host & Microbe 31 (4), 485-499, 2023 | 136 | 2023 |
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics EJ Culp, G Yim, N Waglechner, W Wang, AC Pawlowski, GD Wright Nature Biotechnology 37 (10), 1149-1154, 2019 | 110 | 2019 |
Transformation of the anticancer drug doxorubicin in the human gut microbiome A Yan, E Culp, J Perry, JT Lau, LT MacNeil, MG Surette, GD Wright ACS infectious diseases 4 (1), 68-76, 2018 | 85 | 2018 |
Imipridone anticancer compounds ectopically activate the ClpP protease and represent a new scaffold for antibiotic development S Jacques, AM van der Sloot, C C. Huard, J Coulombe-Huntington, ... Genetics 214 (4), 1103-1120, 2020 | 51 | 2020 |
Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics B Salamaga, L Kong, L Pasquina-Lemonche, L Lafage, ... Proceedings of the National Academy of Sciences 118 (44), e2106022118, 2021 | 45 | 2021 |
The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor D Thomy, E Culp, M Adamek, EY Cheng, N Ziemert, GD Wright, P Sass, ... Applied and environmental microbiology 85 (20), e01292-19, 2019 | 33 | 2019 |
ClpP inhibitors are produced by a widespread family of bacterial gene clusters EJ Culp, D Sychantha, C Hobson, AC Pawlowski, G Prehna, GD Wright Nature microbiology 7 (3), 451-462, 2022 | 32 | 2022 |
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery M Xu, W Wang, N Waglechner, EJ Culp, AK Guitor, GD Wright Nature Communications 11 (1), 5232, 2020 | 29 | 2020 |
Ancient antibiotics, ancient resistance N Waglechner, EJ Culp, GD Wright EcoSal Plus 9 (2), eESP-0027-2020, 2021 | 18 | 2021 |
Phylogeny-informed synthetic biology reveals unprecedented structural novelty in type V glycopeptide antibiotics M Xu, W Wang, N Waglechner, EJ Culp, AK Guitor, GD Wright ACS Central Science 8 (5), 615-626, 2022 | 17 | 2022 |
Genome editing in the nematode Caenorhabditis briggsae using the CRISPR/Cas9 system E Culp, C Richman, D Sharanya, N Jhaveri, W van den Berg, BP Gupta Biology Methods and Protocols 5 (1), bpaa003, 2020 | 13 | 2020 |
Microbial transformation of dietary xenobiotics shapes gut microbiome composition EJ Culp, NT Nelson, AA Verdegaal, AL Goodman Cell 187 (22), 6327-6345. e20, 2024 | 9 | 2024 |
hAMRonization: Enhancing antimicrobial resistance prediction using the PHA4GE AMR detection specification and tooling I Mendes, E Griffiths, A Manuele, D Fornika, SH Tausch, T Le-Viet, ... bioRxiv, 2024.03. 07.583950, 2024 | 6 | 2024 |
Staphylococcus aureus susceptibility to complestatin and corbomycin depends on the VraSR two-component system C Gómez-Arrebola, SB Hernandez, EJ Culp, GD Wright, C Solano, ... Microbiology Spectrum 11 (5), e00370-23, 2023 | 2 | 2023 |
Biosynthetic gene clusters guide rational antibiotic discovery from Actinomycetes E Culp | | 2020 |