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Farrar GJ
Farrar GJ
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Retinopathy induced in mice by targeted disruption of the rhodopsin gene
MM Humphries, D Rancourt, GJ Farrar, P Kenna, M Hazel, RA Bush, ...
Nature genetics 15 (2), 216-219, 1997
6501997
A three-base-pair deletion in the peripherin–RDS gene in one form of retinitis pigmentosa
GJ Farrar, P Kenna, SA Jordan, R Kumar-Singh, MM Humphries, ...
Nature 354 (6353), 478-480, 1991
4971991
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
SL Doyle, M Campbell, E Ozaki, RG Salomon, A Mori, PF Kenna, ...
Nature medicine 18 (5), 791-798, 2012
4922012
On the genetics of retinitis pigmentosa and on mutation‐independent approaches to therapeutic intervention
GJ Farrar, PF Kenna, P Humphries
The EMBO journal, 2002
3062002
Autosomal dominant retinitis pigmentosa (ADRP): localization of an ADRP gene to the long arm of chromosome 3
P McWilliam, GJ Farrar, P Kenna, DG Bradley, MM Humphries, EM Sharp, ...
Genomics 5 (3), 619-622, 1989
2771989
Effective delivery of large genes to the retina by dual AAV vectors
I Trapani, P Colella, A Sommella, C Iodice, G Cesi, S De Simone, ...
EMBO molecular medicine 6 (2), 194-211, 2014
2712014
On the molecular genetics of retinitis pigmentosa
P Humphries, P Kenna, GJ Farrar
Science 256 (5058), 804-808, 1992
2341992
Localizing multiple X chromosome-linked retinitis pigmentosa loci using multilocus homogeneity tests.
J Ott, S Bhattacharya, JD Chen, MJ Denton, J Donald, C Dubay, GJ Farrar, ...
Proceedings of the National Academy of Sciences 87 (2), 701-704, 1990
2341990
RNA interference–mediated suppression and replacement of human rhodopsin in vivo
M O’Reilly, A Palfi, N Chadderton, S Millington-Ward, M Ader, T Cronin, ...
The American Journal of Human Genetics 81 (1), 127-135, 2007
2202007
Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas …
A Kennan, A Aherne, A Palfi, M Humphries, A McKee, A Stitt, ...
Human molecular genetics 11 (5), 547-558, 2002
2142002
Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice
U Bartsch, W Oriyakhel, PF Kenna, S Linke, G Richard, B Petrowitz, ...
Experimental eye research 86 (4), 691-700, 2008
2032008
Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy
N Chadderton, S Millington-Ward, A Palfi, M O'reilly, G Tuohy, ...
Molecular Therapy 17 (4), 593-599, 2009
1812009
Suppression and replacement gene therapy for autosomal dominant disease in a murine model of dominant retinitis pigmentosa
S Millington-Ward, N Chadderton, M O'reilly, A Palfi, T Goldmann, C Kilty, ...
Molecular therapy 19 (4), 642-649, 2011
1782011
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa
CJ Loscher, K Hokamp, PF Kenna, AC Ivens, P Humphries, A Palfi, ...
Genome biology 8, 1-12, 2007
1742007
A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement
SJ Bowne, MM Humphries, LS Sullivan, PF Kenna, L Tam, AS Kiang, ...
European Journal of Human Genetics 19 (10), 1074-1081, 2011
1702011
Modeling and rescue of RP2 retinitis pigmentosa using iPSC-derived retinal organoids
A Lane, K Jovanovic, C Shortall, D Ottaviani, AB Panes, N Schwarz, ...
Stem cell reports 15 (1), 67-79, 2020
1572020
Retinitis pigmentosa and progressive sensorineural hearing loss caused by a C12258A mutation in the mitochondrial MTTS2 gene
FC Mansergh, S Millington-Ward, A Kennan, AS Kiang, M Humphries, ...
The American Journal of Human Genetics 64 (4), 971-985, 1999
1561999
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression
CM Egan, U Nyman, J Skotte, G Streubel, S Turner, DJ O’Connell, ...
Developmental cell 26 (3), 223-236, 2013
1492013
Resolving the dark matter of ABCA4 for 1054 Stargardt disease probands through integrated genomics and transcriptomics
M Khan, SS Cornelis, MD Pozo-Valero, L Whelan, EH Runhart, K Mishra, ...
Genetics in Medicine 22 (7), 1235-1246, 2020
1342020
On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa
A Aherne, A Kennan, PF Kenna, N McNally, DG Lloyd, IL Alberts, ...
Human molecular genetics 13 (6), 641-650, 2004
1322004
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