| Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury T Koga, MA Suico, S Shimasaki, E Watanabe, Y Kai, K Koyama, K Omachi, ... Journal of Biological Chemistry 290 (51), 30366-30374, 2015 | 87 | 2015 |
| Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5 T Yamamura, T Horinouchi, T Adachi, M Terakawa, Y Takaoka, K Omachi, ... Nature communications 11 (1), 2777, 2020 | 79 | 2020 |
| Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis Y Muto, EE Dixon, Y Yoshimura, H Wu, K Omachi, N Ledru, PC Wilson, ... Nature communications 13 (1), 6497, 2022 | 52 | 2022 |
| A split-luciferase-based trimer formation assay as a high-throughput screening platform for therapeutics in Alport syndrome K Omachi, M Kamura, K Teramoto, H Kojima, T Yokota, S Kaseda, ... Cell Chemical Biology 25 (5), 634-643. e4, 2018 | 36 | 2018 |
| Alport syndrome therapeutics: ready for prime-time players K Omachi, JH Miner Trends in Pharmacological Sciences 40 (11), 803-806, 2019 | 29 | 2019 |
| STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model T Yokota, K Omachi, MA Suico, M Kamura, H Kojima, R Fukuda, ... Nephrology Dialysis Transplantation 33 (2), 214-223, 2018 | 29 | 2018 |
| Podocyte p53 limits the severity of experimental Alport syndrome R Fukuda, MA Suico, Y Kai, K Omachi, K Motomura, T Koga, Y Komohara, ... Journal of the American Society of Nephrology 27 (1), 144-157, 2016 | 29 | 2016 |
| A single-cell multiomic analysis of kidney organoid differentiation Y Yoshimura, Y Muto, N Ledru, H Wu, K Omachi, JH Miner, ... Proceedings of the National Academy of Sciences 120 (20), e2219699120, 2023 | 27 | 2023 |
| Trimerization and genotype–phenotype correlation of COL4A5 Mutants in Alport SYNDROME M Kamura, T Yamamura, K Omachi, MA Suico, K Nozu, S Kaseda, ... Kidney international reports 5 (5), 718-726, 2020 | 27 | 2020 |
| Mild electrical stimulation at 0.1-ms pulse width induces p53 protein phosphorylation and G2 arrest in human epithelial cells R Fukuda, MA Suico, K Koyama, K Omachi, Y Kai, S Matsuyama, ... Journal of Biological Chemistry 288 (22), 16117-16126, 2013 | 27 | 2013 |
| Metformin ameliorates the severity of experimental Alport syndrome K Omachi, S Kaseda, T Yokota, M Kamura, K Teramoto, J Kuwazuru, ... Scientific reports 11 (1), 7053, 2021 | 25 | 2021 |
| Comparative analysis of dCas9-VP64 variants and multiplexed guide RNAs mediating CRISPR activation K Omachi, JH Miner Plos one 17 (6), e0270008, 2022 | 23 | 2022 |
| Combined effects of cisplatin and photon or proton irradiation in cultured cells: radiosensitization, patterns of cell death and cell cycle distribution H Iwata, T Shuto, S Kamei, K Omachi, M Moriuchi, C Omachi, T Toshito, ... Journal of Radiation Research 61 (6), 832-841, 2020 | 17 | 2020 |
| Elucidating the proximal tubule HNF4A gene regulatory network in human kidney organoids Y Yoshimura, Y Muto, K Omachi, JH Miner, BD Humphreys Journal of the American Society of Nephrology 34 (10), 1672-1686, 2023 | 16 | 2023 |
| NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough K Omachi, H Kai, M Roberge, JH Miner Iscience 25 (3), 2022 | 11 | 2022 |
| Long-term treatment with EGFR inhibitor erlotinib attenuates renal inflammatory cytokines but not nephropathy in Alport syndrome mouse model K Omachi, R Miyakita, R Fukuda, Y Kai, MA Suico, T Yokota, M Kamura, ... Clinical and experimental nephrology 21, 952-960, 2017 | 11 | 2017 |
| Mild electrical stimulation with heat shock attenuates renal pathology in adriamycin-induced nephrotic syndrome mouse model K Teramoto, Y Tsurekawa, MA Suico, S Kaseda, K Omachi, T Yokota, ... Scientific reports 10 (1), 18719, 2020 | 7 | 2020 |
| Aminoglycoside-induced premature termination codon readthrough of COL4A5 nonsense mutations that cause Alport syndrome K Omachi, H Kai, M Roberge, JH Miner BiorXiv, 2021.06. 11.448099, 2021 | 5 | 2021 |
| Bromide supplementation exacerbated the renal dysfunction, injury and fibrosis in a mouse model of Alport syndrome T Yokota, K Omachi, MA Suico, H Kojima, M Kamura, K Teramoto, ... PLoS One 12 (9), e0183959, 2017 | 5 | 2017 |
| PPARδ agonism ameliorates renal fibrosis in an Alport syndrome mouse model K Omachi, C O'carroll, JH Miner Kidney360 4 (3), 341-348, 2023 | 4 | 2023 |
