mTOR: from growth signal integration to cancer, diabetes and ageing R Zoncu, A Efeyan, DM Sabatini Nature reviews Molecular cell biology 12 (1), 21-35, 2011 | 4847 | 2011 |
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini Cell 141 (2), 290-303, 2010 | 2791 | 2010 |
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford, PH Tang, ... Nature 575 (7784), 688-692, 2019 | 2669 | 2019 |
A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB C Settembre, R Zoncu, DL Medina, F Vetrini, S Erdin, SU Erdin, T Huynh, ... The EMBO journal 31 (5), 1095-1108, 2012 | 2042 | 2012 |
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H+-ATPase R Zoncu, L Bar-Peled, A Efeyan, S Wang, Y Sancak, DM Sabatini Science 334 (6056), 678-683, 2011 | 1884 | 2011 |
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 L Bar-Peled, LD Schweitzer, R Zoncu, DM Sabatini Cell 150 (6), 1196-1208, 2012 | 1074 | 2012 |
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling G Sahay, W Querbes, C Alabi, A Eltoukhy, S Sarkar, C Zurenko, ... Nature biotechnology 31 (7), 653-658, 2013 | 918 | 2013 |
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ... Science 347 (6218), 188-194, 2015 | 862 | 2015 |
Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism RM Perera, S Stoykova, BN Nicolay, KN Ross, J Fitamant, M Boukhali, ... Nature 524 (7565), 361-365, 2015 | 828 | 2015 |
Origin of GABAergic neurons in the human neocortex K Letinic, R Zoncu, P Rakic Nature 417 (6889), 645-649, 2002 | 818 | 2002 |
The lysosome as a cellular centre for signalling, metabolism and quality control RE Lawrence, R Zoncu Nature cell biology 21 (2), 133-142, 2019 | 812 | 2019 |
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 ZY Tsun, L Bar-Peled, L Chantranupong, R Zoncu, T Wang, C Kim, ... Molecular cell 52 (4), 495-505, 2013 | 605 | 2013 |
The lysosome as a regulatory hub RM Perera, R Zoncu Annual review of cell and developmental biology 32 (1), 223-253, 2016 | 595 | 2016 |
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness P Katajisto, J Döhla, CL Chaffer, N Pentinmikko, N Marjanovic, S Iqbal, ... Science 348 (6232), 340-343, 2015 | 572 | 2015 |
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin G Di Paolo, L Pellegrini, K Letinic, G Cestra, R Zoncu, S Voronov, ... Nature 420 (6911), 85-89, 2002 | 549 | 2002 |
DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy TB Nguyen, SM Louie, JR Daniele, Q Tran, A Dillin, R Zoncu, DK Nomura, ... Developmental cell 42 (1), 9-21. e5, 2017 | 540 | 2017 |
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival A Efeyan, R Zoncu, S Chang, I Gumper, H Snitkin, RL Wolfson, O Kirak, ... Nature 493 (7434), 679-683, 2013 | 529 | 2013 |
Amino acids and mTORC1: from lysosomes to disease A Efeyan, R Zoncu, DM Sabatini Trends in molecular medicine 18 (9), 524-533, 2012 | 529 | 2012 |
Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex BM Castellano, AM Thelen, O Moldavski, MK Feltes, REN Van Der Welle, ... Science 355 (6331), 1306-1311, 2017 | 520 | 2017 |
A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes R Zoncu, RM Perera, DM Balkin, M Pirruccello, D Toomre, P De Camilli Cell 136 (6), 1110-1121, 2009 | 405 | 2009 |