| Negatively charged gold nanoparticles inhibit Alzheimer's amyloid‐β fibrillization, induce fibril dissociation, and mitigate neurotoxicity YH Liao, YJ Chang, Y Yoshiike, YC Chang, YR Chen Small 8 (23), 3631-3639, 2012 | 362 | 2012 |
| Distinct early folding and aggregation properties of Alzheimer amyloid-β peptides Aβ40 and Aβ42: stable trimer or tetramer formation by Aβ42 YR Chen, CG Glabe Journal of Biological Chemistry 281 (34), 24414-24422, 2006 | 305 | 2006 |
| Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-β stability, oligomerization, and aggregation: amyloid-β destabilization promotes annular protofibril formation WT Chen, YH Liao, HM Yu, IH Cheng, YR Chen Journal of Biological Chemistry 286 (11), 9646-9656, 2011 | 245 | 2011 |
| Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients YS Fang, KJ Tsai, YJ Chang, P Kao, R Woods, PH Kuo, CC Wu, JY Liao, ... Nature communications 5 (1), 4824, 2014 | 229 | 2014 |
| In vitro prion-like behaviour of TDP-43 in ALS P Smethurst, J Newcombe, C Troakes, R Simone, YR Chen, R Patani, ... Neurobiology of disease 96, 236-247, 2016 | 158 | 2016 |
| Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease MC Lee, WC Yu, YH Shih, CY Chen, ZH Guo, SJ Huang, JCC Chan, ... Scientific reports 8 (1), 4772, 2018 | 147 | 2018 |
| Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies WT Chen, CJ Hong, YT Lin, WH Chang, HT Huang, JY Liao, YJ Chang, ... PloS one 7 (4), e35807, 2012 | 142 | 2012 |
| The glycine-alanine dipeptide repeat from C9orf72 hexanucleotide expansions forms toxic amyloids possessing cell-to-cell transmission properties YJ Chang, US Jeng, YL Chiang, S Hwang, YR Chen Journal of Biological Chemistry 291 (10), 4903-4911, 2016 | 132 | 2016 |
| The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates YT Wang, PH Kuo, CH Chiang, JR Liang, YR Chen, S Wang, JCK Shen, ... Journal of Biological Chemistry 288 (13), 9049-9057, 2013 | 131 | 2013 |
| Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis P Smethurst, E Risse, GE Tyzack, JS Mitchell, DM Taha, YR Chen, ... Brain 143 (2), 430-440, 2020 | 103 | 2020 |
| Amyloid oligomer conformation in a group of natively folded proteins Y Yoshiike, R Minai, Y Matsuo, YR Chen, T Kimura, A Takashima PLoS One 3 (9), e3235, 2008 | 89 | 2008 |
| Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer C Pop, YR Chen, B Smith, K Bose, B Bobay, A Tripathy, S Franzen, ... Biochemistry 40 (47), 14224-14235, 2001 | 88 | 2001 |
| A robust TDP-43 knock-in mouse model of ALS SL Huang, LS Wu, M Lee, CW Chang, WC Cheng, YS Fang, YR Chen, ... Acta neuropathologica communications 8, 1-19, 2020 | 66 | 2020 |
| The coexistence of an equal amount of Alzheimer's amyloid‐β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway YJ Chang, YR Chen The FEBS journal 281 (11), 2674-2687, 2014 | 66 | 2014 |
| Folding stability of amyloid‐β 40 monomer is an important determinant of the nucleation kinetics in fibrillization CL Ni, HP Shi, HM Yu, YC Chang, YR Chen The FASEB Journal 25 (4), 1390-1401, 2011 | 66 | 2011 |
| TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease YH Shih, LH Tu, TY Chang, K Ganesan, WW Chang, PS Chang, YS Fang, ... Nature Communications 11 (1), 5950, 2020 | 65 | 2020 |
| Neuroprotective effect of the marine-derived compound 11-dehydrosinulariolide through DJ-1-related pathway in in vitro and in vivo models of Parkinson’s disease CW Feng, HC Hung, SY Huang, CH Chen, YR Chen, CY Chen, SN Yang, ... Marine Drugs 14 (10), 187, 2016 | 56 | 2016 |
| Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization W Ariesandi, CF Chang, TE Chen, YR Chen PLoS One 8 (1), e53487, 2013 | 49 | 2013 |
| Discovery of dihydrochalcone as potential lead for Alzheimer’s disease: in silico and in vitro study MH Viet, CY Chen, CK Hu, YR Chen, MS Li PloS one 8 (11), e79151, 2013 | 45 | 2013 |
| Alzheimer’s amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway RJ Chen, WW Chang, YC Lin, PL Cheng, YR Chen ACS chemical neuroscience 4 (9), 1287-1296, 2013 | 45 | 2013 |