| PTC124 targets genetic disorders caused by nonsense mutations EM Welch, ER Barton, J Zhuo, Y Tomizawa, WJ Friesen, P Trifillis, ... Nature 447 (7140), 87-91, 2007 | 1458 | 2007 |
| The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins WJ Friesen, S Paushkin, A Wyce, S Massenet, GS Pesiridis, G Van Duyne, ... Molecular and cellular biology 21 (24), 8289-8300, 2001 | 515 | 2001 |
| SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets WJ Friesen, S Massenet, S Paushkin, A Wyce, G Dreyfuss Molecular cell 7 (5), 1111-1117, 2001 | 465 | 2001 |
| A novel WD repeat protein component of the methylosome binds Sm proteins WJ Friesen, A Wyce, S Paushkin, L Abel, J Rappsilber, M Mann, ... Journal of Biological Chemistry 277 (10), 8243-8247, 2002 | 295 | 2002 |
| Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression B Roy, WJ Friesen, Y Tomizawa, JD Leszyk, J Zhuo, B Johnson, J Dakka, ... Proceedings of the National Academy of Sciences 113 (44), 12508-12513, 2016 | 250 | 2016 |
| Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode J Rappsilber, WJ Friesen, S Paushkin, G Dreyfuss, M Mann Analytical chemistry 75 (13), 3107-3114, 2003 | 180 | 2003 |
| Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN) WJ Friesen, G Dreyfuss Journal of Biological Chemistry 275 (34), 26370-26375, 2000 | 180 | 2000 |
| Specific RNA binding proteins constructed from zinc fingers WJ Friesen, MK Darby Nature structural biology 5 (7), 543-546, 1998 | 65 | 1998 |
| Phage display of RNA binding zinc fingers from transcription factor IIIA WJ Friesen, MK Darby Journal of Biological Chemistry 272 (17), 10994-10997, 1997 | 61 | 1997 |
| Tyr-129 is important to the peptide ligand affinity and selectivity of human endothelin type A receptor. JA Lee, JD Elliott, JA Sutiphong, WJ Friesen, EH Ohlstein, JM Stadel, ... Proceedings of the National Academy of Sciences 91 (15), 7164-7168, 1994 | 52 | 1994 |
| The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential WJ Friesen, B Johnson, J Sierra, J Zhuo, P Vazirani, X Xue, Y Tomizawa, ... PLoS One 13 (10), e0206158, 2018 | 51 | 2018 |
| The nucleoside analog clitocine is a potent and efficacious readthrough agent WJ Friesen, CR Trotta, Y Tomizawa, J Zhuo, B Johnson, J Sierra, B Roy, ... RNA 23 (4), 567-577, 2017 | 48 | 2017 |
| Specific RNA Binding by a Single C2H2Zinc Finger WJ Friesen, MK Darby Journal of Biological Chemistry 276 (3), 1968-1973, 2001 | 44 | 2001 |
| New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery MY Ng, H Zhang, A Weil, V Singh, R Jamiolkowski, A Baradaran-Heravi, ... ACS Medicinal Chemistry Letters 9 (12), 1285-1291, 2018 | 32 | 2018 |
| Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations RG Wilde, PD Kennedy, NG Almstead, EM Welch, JJ Takasugi, ... US Patent 7,291,603, 2007 | 14 | 2007 |
| Chemical modifications of G418 (geneticin): Synthesis of novel readthrough aminoglycosides results in an improved in vitro safety window but no improvements in vivo RY Baiazitov, W Friesen, B Johnson, A Mollin, J Sheedy, J Sierra, ... Carbohydrate Research 495, 108058, 2020 | 10 | 2020 |
| Guanidino quinazolines and pyrimidines promote readthrough of premature termination codons in cells with native nonsense mutations C Morrill, WJ Friesen, S Babu, RY Baiazitov, W Du, DB Karloff, CS Lee, ... Bioorganic & Medicinal Chemistry Letters 76, 128989, 2022 | 6 | 2022 |
| Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation WJ Friesen, N Naryshkin, M Patel, C Romfo, E Welch, Y Tomizawa, ... US Patent 8,283,115, 2012 | 5 | 2012 |
| Characterization of PTC124 activity, specificity, and mechanism of action for nonsense mutation suppression EM Welch, J Zhuo, Y Tomizawa, W Friesen, A Branstrom, S Hwang, ... Neurology 64 (6), A175-A176, 2005 | 5 | 2005 |
| Methods of screening for compounds for treating muscular dystrophy using mIGF1 mRNA translation regulation WJ Friesen, N Naryshkin, M Patel, C Romfo, Y Tomizawa, E Welch, ... US Patent 8,741,572, 2014 | 2 | 2014 |
