| Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens A Dixit, O Parnas, B Li, J Chen, CP Fulco, L Jerby-Arnon, ND Marjanovic, ... cell 167 (7), 1853-1866. e17, 2016 | 1600 | 2016 |
| A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response B Adamson, TM Norman, M Jost, MY Cho, JK Nuñez, Y Chen, JE Villalta, ... Cell 167 (7), 1867-1882. e21, 2016 | 1114 | 2016 |
| High-content CRISPR screening C Bock, P Datlinger, F Chardon, MA Coelho, MB Dong, KA Lawson, T Lu, ... Nature Reviews Methods Primers 2 (1), 1-23, 2022 | 492 | 2022 |
| Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq JM Replogle, RA Saunders, AN Pogson, JA Hussmann, A Lenail, A Guna, ... Cell 185 (14), 2559-2575. e28, 2022 | 401 | 2022 |
| Molecular recording of mammalian embryogenesis MM Chan, ZD Smith, S Grosswendt, H Kretzmer, TM Norman, B Adamson, ... Nature 570 (7759), 77-82, 2019 | 354 | 2019 |
| Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing JM Replogle, TM Norman, A Xu, JA Hussmann, J Chen, JZ Cogan, ... Nature biotechnology 38 (8), 954-961, 2020 | 343 | 2020 |
| Memory and modularity in cell-fate decision making TM Norman, ND Lord, J Paulsson, R Losick Nature 503 (7477), 481-486, 2013 | 328 | 2013 |
| Exploring genetic interaction manifolds constructed from rich single-cell phenotypes TM Norman, MA Horlbeck, JM Replogle, AY Ge, A Xu, M Jost, LA Gilbert, ... Science 365 (6455), 786-793, 2019 | 271 | 2019 |
| An epigenetic switch governing daughter cell separation in Bacillus subtilis Y Chai, T Norman, R Kolter, R Losick Genes & development 24 (8), 754-765, 2010 | 221 | 2010 |
| Stochastic switching of cell fate in microbes TM Norman, ND Lord, J Paulsson, R Losick Annual review of microbiology 69 (1), 381-403, 2015 | 198 | 2015 |
| Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis A Chastanet, D Vitkup, GC Yuan, TM Norman, JS Liu, RM Losick Proceedings of the National Academy of Sciences 107 (18), 8486-8491, 2010 | 180 | 2010 |
| Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs M Jost, DA Santos, RA Saunders, MA Horlbeck, JS Hawkins, SM Scaria, ... Nature biotechnology 38 (3), 355-364, 2020 | 149 | 2020 |
| Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis Y Chai, T Norman, R Kolter, R Losick The EMBO journal 30 (7), 1402-1413, 2011 | 99 | 2011 |
| Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis MH Smith, VR Gao, PK Periyakoil, A Kochen, EF DiCarlo, SM Goodman, ... Nature Immunology 24 (7), 1200-1210, 2023 | 68 | 2023 |
| Constraints on fluctuations in sparsely characterized biological systems A Hilfinger, TM Norman, G Vinnicombe, J Paulsson Physical review letters 116 (5), 058101, 2016 | 68 | 2016 |
| Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors JM Replogle, JL Bonnar, AN Pogson, CR Liem, NK Maier, Y Ding, ... Elife 11, e81856, 2022 | 67 | 2022 |
| Stochastic antagonism between two proteins governs a bacterial cell fate switch ND Lord, TM Norman, R Yuan, S Bakshi, R Losick, J Paulsson Science 366 (6461), 116-120, 2019 | 61 | 2019 |
| Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction A Regev, B Adamson, B Cleary, L Cong, A Dixit, J Gaublomme, ... | 57 | 2017 |
| Exploiting natural fluctuations to identify kinetic mechanisms in sparsely characterized systems A Hilfinger, TM Norman, J Paulsson Cell systems 2 (4), 251-259, 2016 | 48 | 2016 |
| Approaches to maximize sgRNA-barcode coupling in Perturb-seq screens B Adamson, TM Norman, M Jost, JS Weissman BioRxiv, 298349, 2018 | 35 | 2018 |