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Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ... Nature communications 9 (1), 4610, 2018 | 371 | 2018 |
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry AD Durbin, MW Zimmerman, NV Dharia, BJ Abraham, AB Iniguez, ... Nature genetics 50 (9), 1240-1246, 2018 | 253 | 2018 |
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets JM Dempster, C Pacini, S Pantel, FM Behan, T Green, J Krill-Burger, ... Nature communications 10 (1), 5817, 2019 | 217 | 2019 |
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 L Chen, G Alexe, NV Dharia, L Ross, AB Iniguez, AS Conway, EJ Wang, ... The Journal of clinical investigation 128 (1), 446-462, 2018 | 147 | 2018 |
A first-generation pediatric cancer dependency map NV Dharia, G Kugener, LM Guenther, CF Malone, AD Durbin, AL Hong, ... Nature genetics 53 (4), 529-538, 2021 | 121 | 2021 |
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression A Renneville, P Van Galen, MC Canver, M McConkey, JM Krill-Burger, ... Blood, The Journal of the American Society of Hematology 126 (16), 1930-1939, 2015 | 121 | 2015 |
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers T Ito, MJ Young, R Li, S Jain, A Wernitznig, JM Krill-Burger, CT Lemke, ... Nature genetics 53 (12), 1664-1672, 2021 | 116 | 2021 |
Multiplex CRISPR/Cas9-based genome editing in human hematopoietic stem cells models clonal hematopoiesis and myeloid neoplasia Z Tothova, JM Krill-Burger, KD Popova, CC Landers, QL Sievers, ... Cell Stem Cell 21 (4), 547-555. e8, 2017 | 104 | 2017 |
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma B Adane, G Alexe, BKA Seong, D Lu, EE Hwang, D Hnisz, CA Lareau, ... Cancer cell 39 (6), 827-844. e10, 2021 | 85 | 2021 |
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML Z Tothova, AL Valton, RA Gorelov, M Vallurupalli, JM Krill-Burger, ... JCI insight 6 (3), e142149, 2021 | 74 | 2021 |
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer SR Viswanathan, MF Nogueira, CG Buss, JM Krill-Burger, MJ Wawer, ... Nature genetics 50 (7), 937-943, 2018 | 69 | 2018 |
MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors TP Howard, TE Arnoff, MR Song, AO Giacomelli, X Wang, AL Hong, ... Cancer research 79 (9), 2404-2414, 2019 | 62 | 2019 |
Expression analysis of human adipose-derived stem cells during in vitro differentiation to an adipocyte lineage L Satish, JM Krill-Burger, PH Gallo, SD Etages, F Liu, BJ Philips, S Ravuri, ... BMC Medical Genomics 8, 1-12, 2015 | 52 | 2015 |
Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography WA LaFramboise, R Dhir, LA Kelly, P Petrosko, JM Krill-Burger, CM Sciulli, ... BMC medicine 10, 1-11, 2012 | 52 | 2012 |
Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer DP Bondeson, BR Paolella, A Asfaw, MV Rothberg, TA Skipper, ... Nature cancer 3 (6), 681-695, 2022 | 46 | 2022 |
Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q JE Neggers, BR Paolella, A Asfaw, MV Rothberg, TA Skipper, A Yang, ... Cell reports 33 (11), 2020 | 38 | 2020 |
Renal cell neoplasms contain shared tumor type–specific copy number variations JM Krill-Burger, MA Lyons, LA Kelly, CM Sciulli, P Petrosko, UR Chandran, ... The American journal of pathology 180 (6), 2427-2439, 2012 | 37 | 2012 |
Small-molecule and CRISPR screening converge to reveal receptor tyrosine kinase dependencies in pediatric rhabdoid tumors EM Oberlick, MG Rees, B Seashore-Ludlow, F Vazquez, GM Nelson, ... Cell reports 28 (9), 2331-2344. e8, 2019 | 34 | 2019 |
Proteins secreted by embryonic stem cells activate cardiomyocytes through ligand binding pathways WA LaFramboise, P Petrosko, JM Krill-Burger, DR Morris, AR McCoy, ... Journal of proteomics 73 (5), 992-1003, 2010 | 33 | 2010 |