| Coactivator condensation at super-enhancers links phase separation and gene control BR Sabari, A Dall’Agnese, A Boija, IA Klein, EL Coffey, K Shrinivas, ... Science 361 (6400), eaar3958, 2018 | 2188 | 2018 |
| Transcription factors activate genes through the phase-separation capacity of their activation domains A Boija, IA Klein, BR Sabari, A Dall’Agnese, EL Coffey, AV Zamudio, ... Cell 175 (7), 1842-1855. e16, 2018 | 1583 | 2018 |
| Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes JM Dowen, ZP Fan, D Hnisz, G Ren, BJ Abraham, LN Zhang, ... Cell 159 (2), 374-387, 2014 | 967 | 2014 |
| Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis M Huch, P Bonfanti, SF Boj, T Sato, CJM Loomans, M Van De Wetering, ... The EMBO journal 32 (20), 2708-2721, 2013 | 760 | 2013 |
| Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers D Hnisz, J Schuijers, CY Lin, AS Weintraub, BJ Abraham, TI Lee, ... Molecular cell 58 (2), 362-370, 2015 | 511 | 2015 |
| Enhancer features that drive formation of transcriptional condensates K Shrinivas, BR Sabari, EL Coffey, IA Klein, A Boija, AV Zamudio, ... Molecular cell 75 (3), 549-561. e7, 2019 | 384 | 2019 |
| Adult mammalian stem cells: the role of Wnt, Lgr5 and R‐spondins J Schuijers, H Clevers The EMBO journal 31 (12), 2685-2696, 2012 | 320 | 2012 |
| Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts J Schuijers, JP Junker, M Mokry, P Hatzis, BK Koo, V Sasselli, ... Cell stem cell 16 (2), 158-170, 2015 | 308 | 2015 |
| Mediator condensates localize signaling factors to key cell identity genes AV Zamudio, A Dall’Agnese, JE Henninger, JC Manteiga, LK Afeyan, ... Molecular cell 76 (5), 753-766. e6, 2019 | 243 | 2019 |
| Wnt‐induced transcriptional activation is exclusively mediated by TCF/LEF J Schuijers, M Mokry, P Hatzis, E Cuppen, H Clevers The EMBO journal 33 (2), 146-156, 2014 | 212 | 2014 |
| Transcriptional dysregulation of MYC reveals common enhancer-docking mechanism J Schuijers, JC Manteiga, AS Weintraub, DS Day, AV Zamudio, D Hnisz, ... Cell reports 23 (2), 349-360, 2018 | 195 | 2018 |
| MeCP2 links heterochromatin condensates and neurodevelopmental disease CH Li, EL Coffey, A Dall’Agnese, NM Hannett, X Tang, JE Henninger, ... Nature 586 (7829), 440-444, 2020 | 182 | 2020 |
| DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus LTJ Kaaij, M van de Wetering, F Fang, B Decato, A Molaro, ... Genome biology 14, 1-15, 2013 | 127 | 2013 |
| Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus J Schuijers, LG van der Flier, J van Es, H Clevers Stem cell reports 3 (2), 234-241, 2014 | 119 | 2014 |
| TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions MP Verzi, P Hatzis, R Sulahian, J Philips, J Schuijers, H Shin, E Freed, ... Proceedings of the National Academy of Sciences 107 (34), 15157-15162, 2010 | 93 | 2010 |
| Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes M Mokry, P Hatzis, J Schuijers, N Lansu, FP Ruzius, H Clevers, E Cuppen Nucleic acids research 40 (1), 148-158, 2012 | 86 | 2012 |
| Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles M Mokry, P Hatzis, E de Bruijn, J Koster, R Versteeg, J Schuijers, ... PloS one 5 (11), e15092, 2010 | 62 | 2010 |
| Regulation and dysregulation of chromosome structure in cancer D Hnisz, J Schuijers, CH Li, RA Young Annual Review of Cancer Biology 2 (1), 21-40, 2018 | 41 | 2018 |
| Coactivator condensation at super-enhancers links phase separation and gene control. Science BR Sabari, A Dall’Agnese, A Boija, IA Klein, EL Coffey, K Shrinivas, ... | 12 | 2018 |
| Targeted perturbation of signaling-driven condensates T Gui, C Fleming, C Manzato, B Bourgeois, N Sirati, J Heuer, ... Molecular Cell 83 (22), 4141-4157. e11, 2023 | 9 | 2023 |
Richard YoungProfessor of Biology, MITGeverifieerd e-mailadres voor wi.mit.edu