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Alan Huang
Alan Huang
Tango Therapeutics
Geverifieerd e-mailadres voor tangotx.com - Homepage
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Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
GM Frampton, SM Ali, M Rosenzweig, J Chmielecki, X Lu, TM Bauer, ...
Cancer discovery 5 (8), 850-859, 2015
8152015
Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor
SM Maira, S Pecchi, A Huang, M Burger, M Knapp, D Sterker, C Schnell, ...
Molecular cancer therapeutics 11 (2), 317-328, 2012
6222012
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas
P Lito, CA Pratilas, EW Joseph, M Tadi, E Halilovic, M Zubrowski, ...
Cancer cell 22 (5), 668-682, 2012
6212012
Convergent loss of PTEN leads to clinical resistance to a PI (3) Kα inhibitor
D Juric, P Castel, M Griffith, OL Griffith, HH Won, H Ellis, SH Ebbesen, ...
Nature 518 (7538), 240-244, 2015
6062015
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials
C Fritsch, A Huang, C Chatenay-Rivauday, C Schnell, A Reddy, M Liu, ...
Molecular cancer therapeutics 13 (5), 1117-1129, 2014
5242014
Single-vector inducible lentiviral RNAi system for oncology target validation
D Wiederschain, W Susan, L Chen, A Loo, G Yang, A Huang, Y Chen, ...
Cell cycle 8 (3), 498-504, 2009
5152009
CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors
SR Vora, D Juric, N Kim, M Mino-Kenudson, T Huynh, C Costa, ...
Cancer cell 26 (1), 136-149, 2014
4712014
Synthetic lethality as an engine for cancer drug target discovery
A Huang, LA Garraway, A Ashworth, B Weber
Nature reviews Drug discovery 19 (1), 23-38, 2020
4502020
Phosphatidylinositol 3-Kinase α–Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study
D Juric, J Rodon, J Tabernero, F Janku, HA Burris, JHM Schellens, ...
Journal of Clinical Oncology 36 (13), 1291-1299, 2018
4212018
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas
M Elkabets, E Pazarentzos, D Juric, Q Sheng, RA Pelossof, S Brook, ...
Cancer cell 27 (4), 533-546, 2015
3242015
mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer
M Elkabets, S Vora, D Juric, N Morse, M Mino-Kenudson, T Muranen, ...
Science translational medicine 5 (196), 196ra99-196ra99, 2013
3202013
Autosomal recessive retinitis pigmentosa caused by mutations in the α subunit of rod cGMP phosphodiesterase
SH Huang, SJ Pittler, X Huang, L Oliveira, EL Berson, TP Dryja
Nature genetics 11 (4), 468-471, 1995
3051995
Correlative analysis of genetic alterations and everolimus benefit in hormone receptor–positive, human epidermal growth factor receptor 2–negative advanced breast cancer …
GN Hortobagyi, D Chen, M Piccart, HS Rugo, HA Burris, KI Pritchard, ...
Journal of Clinical Oncology 34 (5), 419-426, 2016
2882016
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signaling
A Gaither, D Porter, Y Yao, J Borawski, G Yang, J Donovan, D Sage, ...
Cancer research 67 (24), 11493-11498, 2007
2822007
Alpelisib plus fulvestrant in PIK3CA-altered and PIK3CA-wild-type estrogen receptor–positive advanced breast cancer: a phase 1b clinical trial
D Juric, F Janku, J Rodón, HA Burris, IA Mayer, M Schuler, ...
JAMA oncology 5 (2), e184475-e184475, 2019
2512019
Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer
C Costa, H Ebi, M Martini, SA Beausoleil, AC Faber, CT Jakubik, A Huang, ...
Cancer cell 27 (1), 97-108, 2015
2112015
Re-establishing the regenerative potential of central nervous system axons in postnatal mice
KS Cho, L Yang, B Lu, H Feng Ma, X Huang, M Pekny, DF Chen
Journal of cell science 118 (5), 863-872, 2005
1942005
Molecular Cloning, Expression, and Characterization of a Novel Human Serine/Threonine Protein Phosphatase, PP7, That Is Homologous toDrosophila Retinal Degeneration C Gene …
X Huang, RE Honkanen
Journal of Biological Chemistry 273 (3), 1462-1468, 1998
1821998
Genomic analysis of nasopharyngeal carcinoma reveals TME-based subtypes
L Zhang, KD MacIsaac, T Zhou, PY Huang, C Xin, JR Dobson, K Yu, ...
Molecular Cancer Research 15 (12), 1722-1732, 2017
1602017
Optimization of AsCas12a for combinatorial genetic screens in human cells
PC DeWeirdt, KR Sanson, AK Sangree, M Hegde, RE Hanna, MN Feeley, ...
Nature biotechnology 39 (1), 94-104, 2021
1572021
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