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Christopher B Newgard
Christopher B Newgard
Professor and Director, Duke Molecular Physiology Institute
Verifisert e-postadresse på mc.duke.edu
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Gut microbiota from twins discordant for obesity modulate metabolism in mice
VK Ridaura, JJ Faith, FE Rey, J Cheng, AE Duncan, AL Kau, NW Griffin, ...
Science 341 (6150), 1241214, 2013
43832013
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
CB Newgard, J An, JR Bain, MJ Muehlbauer, RD Stevens, LF Lien, ...
Cell metabolism 9 (4), 311-326, 2009
34492009
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
JC Yoon, P Puigserver, G Chen, J Donovan, Z Wu, J Rhee, G Adelmant, ...
Nature 413 (6852), 131-138, 2001
23022001
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
TR Koves, JR Ussher, RC Noland, D Slentz, M Mosedale, O Ilkayeva, ...
Cell metabolism 7 (1), 45-56, 2008
22052008
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
MD Hirschey, T Shimazu, E Goetzman, E Jing, B Schwer, DB Lombard, ...
Nature 464 (7285), 121-125, 2010
18282010
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor
T Shimazu, MD Hirschey, J Newman, W He, K Shirakawa, N Le Moan, ...
Science 339 (6116), 211-214, 2013
17662013
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
DM Muoio, CB Newgard
Nature reviews Molecular cell biology 9 (3), 193-205, 2008
16512008
Interplay between lipids and branched-chain amino acids in development of insulin resistance
CB Newgard
Cell metabolism 15 (5), 606-614, 2012
11152012
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and-independent glucose-stimulated insulin secretion.
HE Hohmeier, H Mulder, G Chen, R Henkel-Rieger, M Prentki, ...
Diabetes 49 (3), 424-430, 2000
10712000
Direct antidiabetic effect of leptin through triglyceride depletion of tissues
M Shimabukuro, K Koyama, G Chen, MY Wang, F Trieu, Y Lee, ...
Proceedings of the National Academy of Sciences 94 (9), 4637-4641, 1997
9251997
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
MD Hirschey, T Shimazu, E Jing, CA Grueter, AM Collins, B Aouizerat, ...
Molecular cell 44 (2), 177-190, 2011
8712011
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP
J Lin, R Yang, PT Tarr, PH Wu, C Handschin, S Li, W Yang, L Pei, M Uldry, ...
Cell 120 (2), 261-273, 2005
8042005
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
LV Blanton, MR Charbonneau, T Salih, MJ Barratt, S Venkatesh, ...
Science 351 (6275), aad3311, 2016
7672016
Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high‐fat diet
BP Sampey, AM Vanhoose, HM Winfield, AJ Freemerman, ...
Obesity 19 (6), 1109-1117, 2011
7642011
Metabolomics and metabolic diseases: where do we stand?
CB Newgard
Cell metabolism 25 (1), 43-56, 2017
7572017
Metabolic coupling factors in pancreatic beta-cell signal transduction.
CB Newgard, JD McGarry
Annual review of biochemistry 64, 689-719, 1995
7491995
STZ transport and cytotoxicity: specific enhancement in GLUT2-expressing cells
WJ Schnedl, S Ferber, JH Johnson, CB Newgard
Diabetes 43 (11), 1326-1333, 1994
7481994
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
VA Gerriets, RJ Kishton, AG Nichols, AN Macintyre, M Inoue, O Ilkayeva, ...
The Journal of clinical investigation 125 (1), 194-207, 2015
7392015
Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
J St-Pierre, J Lin, S Krauss, PT Tarr, R Yang, CB Newgard, ...
Journal of Biological Chemistry 278 (29), 26597-26603, 2003
7112003
Use of recombinant adenovirus for metabolic engineering of mammalian cells
TC Becker, RJ Noel, WS Coats, AM Gomez-Foix, T Alam, RD Gerard, ...
Methods in cell biology 43, 161-189, 1994
7101994
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Artikler 1–20