| Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury BT Lang, JM Cregg, MA DePaul, AP Tran, K Xu, SM Dyck, KM Madalena, ... Nature 518 (7539), 404-408, 2015 | 483 | 2015 |
| On-target resistance to the mutant-selective EGFR inhibitor osimertinib can develop in an allele-specific manner dependent on the original EGFR-activating mutation BP Brown, YK Zhang, D Westover, Y Yan, H Qiao, V Huang, Z Du, ... Clinical Cancer Research 25 (11), 3341-3351, 2019 | 101 | 2019 |
| Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity AB Hanker, BP Brown, J Meiler, A Marín, HS Jayanthan, D Ye, CC Lin, ... Cancer cell 39 (8), 1099-1114. e8, 2021 | 71 | 2021 |
| Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting Z Du, BP Brown, S Kim, D Ferguson, DC Pavlick, G Jayakumaran, ... Nature Communications 12 (1), 1382, 2021 | 67 | 2021 |
| General purpose structure-based drug discovery neural network score functions with human-interpretable pharmacophore maps BP Brown, J Mendenhall, AR Geanes, J Meiler Journal of chemical information and modeling 61 (2), 603-620, 2021 | 38 | 2021 |
| BCL:: Conf: improved open-source knowledge-based conformation sampling using the crystallography open database J Mendenhall, BP Brown, S Kothiwale, J Meiler Journal of chemical information and modeling 61 (1), 189-201, 2020 | 34 | 2020 |
| In vivo and in vitro ketamine exposure exhibits a dose-dependent induction of activity-dependent neuroprotective protein in rat neurons BP Brown, SC Kang, K Gawelek, RA Zacharias, SR Anderson, CP Turner, ... Neuroscience 290, 31-40, 2015 | 30 | 2015 |
| Computationally designed cyclic peptides derived from an antibody loop increase breadth of binding for influenza variants AM Sevy, IM Gilchuk, BP Brown, NG Bozhanova, R Nargi, M Jensen, ... Structure 28 (10), 1114-1123. e4, 2020 | 27 | 2020 |
| Introduction to the BioChemical Library (BCL): An application-based open-source toolkit for integrated cheminformatics and machine learning in computer-aided drug discovery BP Brown, O Vu, AR Geanes, S Kothiwale, M Butkiewicz, EW Lowe Jr, ... Frontiers in pharmacology 13, 833099, 2022 | 23 | 2022 |
| BCL:: MolAlign: three-dimensional small molecule alignment for pharmacophore mapping BP Brown, J Mendenhall, J Meiler Journal of chemical information and modeling 59 (2), 689-701, 2019 | 23 | 2019 |
| Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer BP Brown, YK Zhang, S Kim, P Finneran, Y Yan, Z Du, J Kim, AL Hartzler, ... Proceedings of the National Academy of Sciences 119 (30), e2206588119, 2022 | 21 | 2022 |
| Approximating projections of conformational Boltzmann distributions with AlphaFold2 predictions: opportunities and limitations BP Brown, RA Stein, J Meiler, HS Mchaourab Journal of Chemical Theory and Computation 20 (3), 1434-1447, 2024 | 18 | 2024 |
| Acquired Secondary HER2 Mutations Enhance HER2/MAPK Signaling and Promote Resistance to HER2 Kinase Inhibition in Breast Cancer A Marín, AA Mamun, H Patel, H Akamatsu, D Ye, DR Sudhan, L Eli, ... Cancer research 83 (18), 3145-3158, 2023 | 11 | 2023 |
| Lipocalin Blc is a potential heme‐binding protein NG Bozhanova, MW Calcutt, WN Beavers, BP Brown, EP Skaar, J Meiler FEBS letters 595 (2), 206-219, 2021 | 5 | 2021 |
| Macrocyclic octapeptide binding and inferences on protein substrate binding to histone deacetylase 6 PR Watson, S Gupta, P Hosseinzadeh, BP Brown, D Baker, ... ACS chemical biology 18 (4), 959-968, 2023 | 4 | 2023 |
| Dissecting monomer-dimer equilibrium of an RNase P protein provides insight into the synergistic flexibility of 5’leader pre-tRNA recognition D Zeng, A Abzhanova, BP Brown, NJ Reiter Frontiers in Molecular Biosciences 8, 730274, 2021 | 4 | 2021 |
| NMR resonance assignments of RNase P protein from Thermotoga maritima D Zeng, BP Brown, MW Voehler, S Cai, NJ Reiter Biomolecular NMR assignments 12, 183-187, 2018 | 2 | 2018 |
| Computer-Aided Design and Biological Evaluation of Diazaspirocyclic D4R Antagonists CAH Jones, BP Brown, DC Schultz, J Engers, VM Kramlinger, J Meiler, ... ACS chemical neuroscience 15 (12), 2396-2407, 2024 | 1 | 2024 |
| Toward automated design of mutant-selective tyrosine kinase inhibitors using dynamic pharmacophore mapping and machine learning BP Brown, J Mendenhall, C Lovly, J Meiler Clinical Cancer Research 26 (12_Supplement_1), 22-22, 2020 | | 2020 |
Jens MeilerVanderbilt University & University LeipzigVerifisert e-postadresse på meilerlab.org