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Luke Slade
Luke Slade
Verifisert e-postadresse på bioch.ox.ac.uk
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Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model
RA Ellwood, JE Hewitt, R Torregrossa, AM Philp, JP Hardee, S Hughes, ...
Proceedings of the National Academy of Sciences 118 (9), e2018342118, 2021
382021
The mitochondria‐targeted hydrogen sulfide donor AP39 improves health and mitochondrial function in a C. elegans primary mitochondrial disease model
BC Fox, L Slade, R Torregrossa, D Pacitti, C Szabo, T Etheridge, ...
Journal of Inherited Metabolic Disease 44 (2), 367-375, 2021
162021
Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans
AR Vintila, L Slade, M Cooke, CRG Willis, R Torregrossa, M Rahman, ...
Proceedings of the National Academy of Sciences 120 (32), e2216141120, 2023
132023
Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy
RA Ellwood, L Slade, J Lewis, R Torregrossa, S Sudevan, M Piasecki, ...
Communications Biology 5 (1), 1255, 2022
112022
An evaluation of the role of miR-361-5p in senescence and systemic ageing
E Manni, N Jeffery, D Chambers, L Slade, T Etheridge, LW Harries
Experimental Gerontology 174, 112127, 2023
62023
Hydrogen sulfide supplementation as a potential treatment for primary mitochondrial diseases
L Slade, CS Deane, NJ Szewczyk, T Etheridge, M Whiteman
Pharmacological Research, 107180, 2024
52024
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline
L Slade, T Etheridge, NJ Szewczyk
Ageing Research Reviews, 102456, 2024
32024
Bisphosphonates attenuate age‐related muscle decline in Caenorhabditis elegans
L Slade, SE Bollen, JJ Bass, BE Phillips, K Smith, DJ Wilkinson, ...
Journal of Cachexia, Sarcopenia and Muscle 14 (6), 2613-2622, 2023
32023
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
D Petrovic, L Slade, Y Paikopoulos, D D’Andrea, N Savic, A Stancic, ...
Cell metabolism 37 (2), 542-556. e14, 2025
12025
Proximate Causes of Ageing Are Likely Evolutionarily Bound and Appropriate Countermeasure Design Requires New Approaches
L Slade, T Etheridge, N Szewczyk
2024
The role of hydrogen sulfide supplementation in Caenorhabditis elegans ageing and disease models of mitochondrial dysfunction
L Slade
University of Exeter, 2024
2024
Global persulfidome changes in aging C. elegans
M Filipovic, D Petrovic, L Slade
Free Radical Biology and Medicine 208, S53, 2023
2023
Mitochondrial targeted Hydrogen Sulfide as a regulator of ageing in Caenorhabditis elegans.
L Slade
University of Exeter, 2020
2020
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Artikler 1–13