| Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage W Lee, HA Leddy, Y Chen, SH Lee, NA Zelenski, AL McNulty, J Wu, ... Proceedings of the National Academy of Sciences 111 (47), E5114-E5122, 2014 | 464 | 2014 |
| Regulation of pain and itch by TRP channels C Moore, R Gupta, SE Jordt, Y Chen, WB Liedtke Neuroscience bulletin 34, 120-142, 2018 | 299 | 2018 |
| UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling C Moore, F Cevikbas, HA Pasolli, Y Chen, W Kong, C Kempkes, P Parekh, ... Proceedings of the National Academy of Sciences 110 (34), E3225-E3234, 2013 | 263 | 2013 |
| Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway Y Chen, C Geis, C Sommer Journal of neuroscience 28 (22), 5836-5845, 2008 | 200 | 2008 |
| A craniofacial-specific monosynaptic circuit enables heightened affective pain E Rodriguez, K Sakurai, J Xu, Y Chen, K Toda, S Zhao, BX Han, D Ryu, ... Nature neuroscience 20 (12), 1734-1743, 2017 | 191 | 2017 |
| Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis W Lee, RJ Nims, A Savadipour, Q Zhang, HA Leddy, F Liu, AL McNulty, ... Proceedings of the National Academy of Sciences 118 (13), e2001611118, 2021 | 182 | 2021 |
| Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch Y Chen, Q Fang, Z Wang, JY Zhang, AS MacLeod, RP Hall, WB Liedtke Journal of Biological Chemistry 291 (19), 10252-10262, 2016 | 143 | 2016 |
| General anesthetics activate a potent central pain-suppression circuit in the amygdala T Hua, B Chen, D Lu, K Sakurai, S Zhao, BX Han, J Kim, L Yin, Y Chen, ... Nature neuroscience 23 (7), 854-868, 2020 | 141 | 2020 |
| Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion Y Chen, SH Williams, AL McNulty, JH Hong, SH Lee, NE Rothfusz, ... Pain® 154 (8), 1295-1304, 2013 | 140 | 2013 |
| Differences in inflammatory pain in nNOS-, iNOS-and eNOS-deficient mice MK Boettger, N Üceyler, M Zelenka, A Schmitt, A Reif, Y Chen, C Sommer European journal of pain 11 (7), 810-818, 2007 | 133 | 2007 |
| IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice X Luo, O Chen, Z Wang, S Bang, J Ji, SH Lee, Y Huh, K Furutani, Q He, ... Neuron 109 (17), 2691-2706. e5, 2021 | 120 | 2021 |
| Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice Y Chen, MK Boettger, A Reif, A Schmitt, N Üçeyler, C Sommer Molecular pain 6, 1744-8069-6-13, 2010 | 116 | 2010 |
| Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain Y Chen, HH Willcockson, JG Valtschanoff Experimental neurology 220 (2), 383-390, 2009 | 113 | 2009 |
| The role of mitogen-activated protein kinase (MAPK) in morphine tolerance and dependence Y Chen, C Sommer Molecular neurobiology 40, 101-107, 2009 | 113 | 2009 |
| TRP channels and pain R González-Ramírez, Y Chen, WB Liedtke, SL Morales-Lázaro Neurobiology of TRP channels 1, 125-147, 2017 | 104 | 2017 |
| TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor Y Chen, P Kanju, Q Fang, SH Lee, PK Parekh, W Lee, C Moore, ... PAIN® 155 (12), 2662-2672, 2014 | 88 | 2014 |
| Epithelia-sensory neuron cross talk underlies cholestatic itch induced by lysophosphatidylcholine Y Chen, ZL Wang, M Yeo, QJ Zhang, AE López-Romero, HP Ding, ... Gastroenterology 161 (1), 301-317. e16, 2021 | 82 | 2021 |
| Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain P Kanju, Y Chen, W Lee, M Yeo, SH Lee, J Romac, R Shahid, P Fan, ... Scientific reports 6 (1), 26894, 2016 | 81 | 2016 |
| Nociceptin and its receptor in rat dorsal root ganglion neurons in neuropathic and inflammatory pain models: implications on pain processing Y Chen, C Sommer Journal of the Peripheral Nervous System 11 (3), 232-240, 2006 | 69 | 2006 |
| Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritis Y Chen, HH Willcockson, JG Valtschanoff Osteoarthritis and cartilage 17 (2), 244-251, 2009 | 53 | 2009 |
Wolfgang LiedtkeChair of Neurology, Psychiatry, Pain Medicine and Sensory Systems; Global Development CouncilVerifisert e-postadresse på regeneron.com