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Valerie G Brunton
Valerie G Brunton
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Verifisert e-postadresse på ed.ac.uk
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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
U Wellner, J Schubert, UC Burk, O Schmalhofer, F Zhu, A Sonntag, ...
Nature cell biology 11 (12), 1487-1495, 2009
19622009
The role of focal-adhesion kinase in cancer—a new therapeutic opportunity
GW McLean, NO Carragher, E Avizienyte, J Evans, VG Brunton, ...
Nature Reviews Cancer 5 (7), 505-515, 2005
12732005
The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
AM Krebs, J Mitschke, M Lasierra Losada, O Schmalhofer, M Boerries, ...
Nature cell biology 19 (5), 518-529, 2017
9902017
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
JP Morton, P Timpson, SA Karim, RA Ridgway, D Athineos, B Doyle, ...
Proceedings of the National Academy of Sciences 107 (1), 246-251, 2010
7922010
E-cadherin–integrin crosstalk in cancer invasion and metastasis
M Canel, A Serrels, MC Frame, VG Brunton
Journal of cell science 126 (2), 393-401, 2013
7892013
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth
MS Samuel, JI Lopez, EJ McGhee, DR Croft, D Strachan, P Timpson, ...
Cancer cell 19 (6), 776-791, 2011
5982011
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
A Hamilton, GV Helgason, M Schemionek, B Zhang, S Myssina, EK Allan, ...
Blood, The Journal of the American Society of Hematology 119 (6), 1501-1510, 2012
5012012
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
E Avizienyte, AW Wyke, RJ Jones, GW McLean, MA Westhoff, VG Brunton, ...
Nature cell biology 4 (8), 632-638, 2002
4732002
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity
A Serrels, T Lund, B Serrels, A Byron, RC McPherson, A von Kriegsheim, ...
Cell 163 (1), 160-173, 2015
4072015
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
M Zimmermann, O Murina, MAM Reijns, A Agathanggelou, R Challis, ...
Nature 559 (7713), 285-289, 2018
3892018
Mouse models of metastasis: progress and prospects
L Gómez-Cuadrado, N Tracey, R Ma, B Qian, VG Brunton
Disease models & mechanisms 10 (9), 1061-1074, 2017
3602017
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex
B Serrels, A Serrels, VG Brunton, M Holt, GW McLean, CH Gray, ...
Nature cell biology 9 (9), 1046-1056, 2007
3222007
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane
E Sandilands, C Cans, VJ Fincham, VG Brunton, H Mellor, ...
Developmental cell 7 (6), 855-869, 2004
3172004
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells
M Agochiya, VG Brunton, DW Owens, EK Parkinson, C Paraskeva, ...
Oncogene 18 (41), 5646-5653, 1999
3111999
Stimulated Raman scattering microscopy: an emerging tool for drug discovery
WJ Tipping, M Lee, A Serrels, VG Brunton, AN Hulme
Chemical Society Reviews 45 (8), 2075-2089, 2016
2842016
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell …
VG Brunton, E Avizienyte, VJ Fincham, B Serrels, CA Metcalf III, ...
Cancer research 65 (4), 1335-1342, 2005
2672005
Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity
P Timpson, GE Jones, MC Frame, VG Brunton
Current biology 11 (23), 1836-1846, 2001
2402001
Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry
VG Brunton, IRJ MacPherson, MC Frame
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1692 (2-3), 121-144, 2004
2342004
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function
NO Carragher, SM Walker, LA Scott Carragher, F Harris, TK Sawyer, ...
Oncogene 25 (42), 5726-5740, 2006
2192006
Src and focal adhesion kinase as therapeutic targets in cancer
VG Brunton, MC Frame
Current opinion in pharmacology 8 (4), 427-432, 2008
2182008
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Artikler 1–20