Prof. Assaf Friedler

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Zvi HayoukaThe Robert H. Smith Faculty of Agriculture, Food and Environment,The Hebrew University of JerusalemVerifisert e-postadresse på mail.huji.ac.il
Alan FershtEmeritus Group Leader, MRC Laboratory of Molecular Biology, University of CambridgeVerifisert e-postadresse på cam.ac.uk
Chaim GilonProfessor Emeritus Active, Institute of Chemistry, HUJIVerifisert e-postadresse på mail.huji.ac.il
Deborah E ShalevHebrew University of JerusalemVerifisert e-postadresse på mail.huji.ac.il
Dmitry VeprintsevProfessor of Molecular and Cellular Pharmacology, University of NottinghamVerifisert e-postadresse på nottingham.ac.uk
Mattan HurevichAssociate Professor, Institute of Chemistry The Hebrew UniversityVerifisert e-postadresse på mail.huji.ac.il
Joseph RosenbluhDepartment of Biochemistry & Molecular Biology, Monash UniversityVerifisert e-postadresse på monash.edu
Rachel NechushtaiThe Hebrew University of JerusalemVerifisert e-postadresse på mail.huji.ac.il
Oded LivnahVerifisert e-postadresse på mail.huji.ac.il
Shahar SukenikDept. of Chemistry, Syracuse UniversityVerifisert e-postadresse på syr.edu
Eric J SundbergEmory University School of MedicineVerifisert e-postadresse på emory.edu
KOUSHIK CHANDRAAssociate Professor in ChemistryVerifisert e-postadresse på midnaporecollege.ac.in
Daniel HarriesInstitute of Chemistry, The Hebrew UniversityVerifisert e-postadresse på mail.huji.ac.il
Hermona SoreqProfessor of Molecular Neurobiology, The Hebrew University of JerusalemVerifisert e-postadresse på mail.huji.ac.il
Daniel BonsorFrederick National Laboratory for Cancer ResearchVerifisert e-postadresse på nih.gov
Penka NikolovaEmeritus Associate Professor (Reader), King's College LondonVerifisert e-postadresse på kcl.ac.uk
Patricia A. JenningsProfessor of Chemistry and Biochemistry, UCSDVerifisert e-postadresse på ucsd.edu
Tiago RitoThe Francis Crick InstituteVerifisert e-postadresse på crick.ac.uk
Shoshana RavidProfessor of BiochemistryVerifisert e-postadresse på mail.huji.ac.il
Robert Benny GerberThe Hebrew University of Jerusalem, University of California at Irvine, University of HelsinkiVerifisert e-postadresse på fh.huji.ac.il

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Prof. Assaf Friedler

Institute of Chemistry, The Hebrew University of Jerusalem

Verifisert e-postadresse på mail.huji.ac.il - Startside

peptides protein interactions medicinal chemistry biophysical chemistry intrinsically disordered proteins


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Molecular mechanism of the interaction between MDM2 and p53 O Schon, A Friedler, M Bycroft, SMV Freund, AR Fersht Journal of molecular biology 323 (3), 491-501, 2002	459	2002
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants A Friedler, LO Hansson, DB Veprintsev, SMV Freund, TM Rippin, ... Proceedings of the National Academy of Sciences 99 (2), 937-942, 2002	346	2002
Studying protein–protein interactions using peptide arrays C Katz, L Levy-Beladev, S Rotem-Bamberger, T Rito, SGD Rüdiger, ... Chemical Society Reviews 40 (5), 2131-2145, 2011	238	2011
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium Z Hayouka, J Rosenbluh, A Levin, S Loya, M Lebendiker, D Veprintsev, ... Proceedings of the National Academy of Sciences 104 (20), 8316-8321, 2007	237	2007
Butyrylcholinesterase attenuates amyloid fibril formation in vitro S Diamant, E Podoly, A Friedler, H Ligumsky, O Livnah, H Soreq Proceedings of the National Academy of Sciences 103 (23), 8628-8633, 2006	209	2006
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide N Issaeva, A Friedler, P Bozko, KG Wiman, AR Fersht, G Selivanova Proceedings of the National Academy of Sciences 100 (23), 13303-13307, 2003	194	2003
The C terminus of p53 binds the N-terminal domain of MDM2 MV Poyurovsky, C Katz, O Laptenko, R Beckerman, M Lokshin, J Ahn, ... Nature structural & molecular biology 17 (8), 982-989, 2010	177	2010
Two sequence motifs from HIF-1α bind to the DNA-binding site of p53 LO Hansson, A Friedler, S Freund, S Rüdiger, AR Fersht Proceedings of the National Academy of Sciences 99 (16), 10305-10309, 2002	174	2002
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules A Friedler, DB Veprintsev, LO Hansson, AR Fersht Journal of Biological Chemistry 278 (26), 24108-24112, 2003	173	2003
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation D Mayer, FF Damberger, M Samarasimhareddy, M Feldmueller, ... Nature communications 10 (1), 1261, 2019	116	2019
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation A Friedler, DB Veprintsev, SMV Freund, KI von Glos, AR Fersht Structure 13 (4), 629-636, 2005	112	2005
The structure of an FF domain from human HYPA/FBP11 M Allen, A Friedler, O Schon, M Bycroft Journal of molecular biology 323 (3), 411-416, 2002	110	2002
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for “mutant conformation” A Friedler, BS DeDecker, SMV Freund, C Blair, S Rüdiger, AR Fersht Journal of molecular biology 336 (1), 187-196, 2004	89	2004
Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling J Petersen, SC Wright, D Rodríguez, P Matricon, N Lahav, A Vromen, ... Nature communications 8 (1), 226, 2017	86	2017
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein Z Hayouka, M Hurevich, A Levin, H Benyamini, A Iosub, M Maes, ... Bioorganic & medicinal chemistry 18 (23), 8388-8395, 2010	83	2010
Chemical synthesis and expression of the HIV‐1 Rev protein P Siman, O Blatt, T Moyal, T Danieli, M Lebendiker, HA Lashuel, ... ChemBioChem 12 (7), 1097-1104, 2011	81	2011
Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif A Friedler, D Friedler, NW Luedtke, Y Tor, A Loyter, C Gilon Journal of biological chemistry 275 (31), 23783-23789, 2000	80	2000
Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in … A Friedler, N Zakai, O Karni, YC Broder, L Baraz, M Kotler, A Loyter, ... Biochemistry 37 (16), 5616-5622, 1998	79	1998
Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes O Schon, A Friedler, S Freund, AR Fersht Journal of molecular biology 336 (1), 197-202, 2004	77	2004
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53 A Friedler, DB Veprintsev, T Rutherford, KI von Glos, AR Fersht Journal of Biological Chemistry 280 (9), 8051-8059, 2005	75	2005

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