| Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility International Multiple Sclerosis Genetics Consortium*†, ANZgene, ... Science 365 (6460), eaav7188, 2019 | 1153* | 2019 |
| Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci PL De Jager, G Srivastava, K Lunnon, J Burgess, LC Schalkwyk, L Yu, ... Nature neuroscience 17 (9), 1156-1163, 2014 | 996 | 2014 |
| Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus J Bentham, DL Morris, DS Cunninghame Graham, CL Pinder, ... Nature genetics 47 (12), 1457-1464, 2015 | 976 | 2015 |
| Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes T Raj, K Rothamel, S Mostafavi, C Ye, MN Lee, JM Replogle, T Feng, ... Science 344 (6183), 519-523, 2014 | 559 | 2014 |
| Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing JK Nuñez, J Chen, GC Pommier, JZ Cogan, JM Replogle, C Adriaens, ... Cell 184 (9), 2503-2519. e17, 2021 | 535 | 2021 |
| Nucleosomes impede Cas9 access to DNA in vivo and in vitro MA Horlbeck, LB Witkowsky, B Guglielmi, JM Replogle, LA Gilbert, ... elife 5, e12677, 2016 | 452 | 2016 |
| Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq JM Replogle, RA Saunders, AN Pogson, JA Hussmann, A Lenail, A Guna, ... Cell 185 (14), 2559-2575. e28, 2022 | 405 | 2022 |
| Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing JM Replogle, TM Norman, A Xu, JA Hussmann, J Chen, JZ Cogan, ... Nature biotechnology 38 (8), 954-961, 2020 | 357 | 2020 |
| Mapping transcriptomic vector fields of single cells X Qiu, Y Zhang, JD Martin-Rufino, C Weng, S Hosseinzadeh, D Yang, ... Cell 185 (4), 690-711. e45, 2022 | 312 | 2022 |
| Exploring genetic interaction manifolds constructed from rich single-cell phenotypes TM Norman, MA Horlbeck, JM Replogle, AY Ge, A Xu, M Jost, LA Gilbert, ... Science 365 (6455), 786-793, 2019 | 278 | 2019 |
| Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution D Yang, MG Jones, S Naranjo, WM Rideout, KHJ Min, R Ho, W Wu, ... Cell 185 (11), 1905-1923. e25, 2022 | 218 | 2022 |
| Efficient C• G-to-G• C base editors developed using CRISPRi screens, target-library analysis, and machine learning LW Koblan, M Arbab, MW Shen, JA Hussmann, AV Anzalone, JL Doman, ... Nature biotechnology 39 (11), 1414-1425, 2021 | 189 | 2021 |
| CD33 modulates TREM2: convergence of Alzheimer loci G Chan, CC White, PA Winn, M Cimpean, JM Replogle, LR Glick, ... Nature neuroscience 18 (11), 1556-1558, 2015 | 172 | 2015 |
| CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility T Raj, KJ Ryan, JM Replogle, LB Chibnik, L Rosenkrantz, A Tang, ... Human molecular genetics 23 (10), 2729-2736, 2014 | 163 | 2014 |
| A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants KJ Ryan, CC White, K Patel, J Xu, M Olah, JM Replogle, M Frangieh, ... Science translational medicine 9 (421), eaai7635, 2017 | 145 | 2017 |
| GIGYF2 and 4EHP inhibit translation initiation of defective messenger RNAs to assist ribosome-associated quality control KL Hickey, K Dickson, JZ Cogan, JM Replogle, M Schoof, KN D’Orazio, ... Molecular cell 79 (6), 950-962. e6, 2020 | 143 | 2020 |
| Common risk alleles for inflammatory diseases are targets of recent positive selection T Raj, M Kuchroo, JM Replogle, S Raychaudhuri, BE Stranger, ... The American Journal of Human Genetics 92 (4), 517-529, 2013 | 135 | 2013 |
| Interindividual variation in human T regulatory cells A Ferraro, AM D’Alise, T Raj, N Asinovski, R Phillips, A Ergun, ... Proceedings of the National Academy of Sciences 111 (12), E1111-E1120, 2014 | 125 | 2014 |
| Microfluidics-free single-cell genomics with templated emulsification IC Clark, KM Fontanez, RH Meltzer, Y Xue, C Hayford, A May-Zhang, ... Nature Biotechnology 41 (11), 1557-1566, 2023 | 113 | 2023 |
| MTCH2 is a mitochondrial outer membrane protein insertase A Guna, TA Stevens, AJ Inglis, JM Replogle, TK Esantsi, G Muthukumar, ... Science 378 (6617), 317-322, 2022 | 97 | 2022 |
Jonathan S. WeissmanUCSF/HHMIVerifisert e-postadresse på ucsf.edu