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Jacob Househam
Jacob Househam
Data Science Team, The Institute of Cancer Research
Verifisert e-postadresse på icr.ac.uk - Startside
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Phenotypic plasticity and genetic control in colorectal cancer evolution
J Househam, T Heide, GD Cresswell, I Spiteri, C Kimberley, L Zapata, ...
Nature 611 (7937), 744-753, 2022
1242022
Evolutionary dynamics of neoantigens in growing tumors
E Lakatos, MJ Williams, RO Schenck, WCH Cross, J Househam, L Zapata, ...
Nature genetics 52 (10), 1057-1066, 2020
1122020
The co-evolution of the genome and epigenome in colorectal cancer
T Heide, J Househam, GD Cresswell, I Spiteri, C Lynn, M Mossner, ...
Nature 611 (7937), 733-743, 2022
882022
Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
C Gabbutt, RO Schenck, DJ Weisenberger, C Kimberley, A Berner, ...
Nature biotechnology 40 (5), 720-730, 2022
432022
The genomic landscape of 2,023 colorectal cancers
AJ Cornish, AJ Gruber, B Kinnersley, D Chubb, A Frangou, G Caravagna, ...
Nature 633 (8028), 127-136, 2024
342024
Phenotypic noise and plasticity in cancer evolution
FJH Whiting, J Househam, AM Baker, A Sottoriva, TA Graham
Trends in Cell Biology 34 (6), 451-464, 2024
132024
Integrated quality control of allele-specific copy numbers, mutations and tumour purity from cancer whole genome sequencing assays
J Househam, R Bergamin, S Milite, N Calonaci, A Antonello, MJ Williams, ...
BLENDING BIOLOGY AND BIOINFORMATICS, 38, 2021
12*2021
Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
AJ Cornish, AJ Gruber, B Kinnersley, D Chubb, A Frangou, G Caravagna, ...
BioRxiv, 2022.11. 16.515599, 2022
102022
Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A
DP Hart, N Uzun, S Skelton, A Kakoschke, J Househam, DS Moss, ...
haematologica 104 (3), 599, 2018
82018
Computational validation of clonal and subclonal copy number alterations from bulk tumor sequencing using CNAqc
A Antonello, R Bergamin, N Calonaci, J Househam, S Milite, MJ Williams, ...
Genome Biology 25 (1), 38, 2024
22024
Long deletion signatures in repetitive genomic regions track somatic evolution and enable sensitive detection of microsatellite instability
Q Guo, J Househam, E Lakatos, S Nowinski, I Al Bakir, H Grant, ...
bioRxiv, 2024.10. 03.616572, 2024
12024
Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer
E Lakatos, V Gunasri, L Zapata, J Househam, T Heide, N Trahearn, ...
bioRxiv, 2024
12024
Evolutionary dynamics of 1,976 lymphoid malignancies predict clinical outcome
C Gabbutt, M Duran-Ferrer, H Grant, D Mallo, F Nadeu, J Househam, ...
medRxiv, 2023.11. 10.23298336, 2023
12023
Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of oesophagael adenocarcinoma
M Barroux, J Househam, E Lakatos, T Ronel, AM Baker, H Salié, ...
Research Square, rs. 3. rs-2738048, 2023
12023
Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data
T Heide, J Househam, GD Cresswell, I Spiteri, C Lynn, C Kimberley, ...
bioRxiv, 2021.07. 14.451265, 2021
12021
Computational validation of clonal and subclonal copy number alterations from bulk tumour sequencing
A Antonello, R Bergamin, N Calonaci, J Househam, S Milite, MJ Williams, ...
bioRxiv, 2021.02. 13.429885, 2021
12021
MEMORI-Methods for computational analyses
M Barroux, J Househam, E Lakatos, T Ronel, T Graham
2025
Evolutionary dynamics of phenotypic plasticity in metastatic colorectal cancer
M Mossner, J Househam, P Kyle, D Donato-Brown, SL Woods, T Heide, ...
JOURNAL OF PATHOLOGY 264, S6-S6, 2024
2024
153P Determinants of tumour-immune evolutionary trajectory in colorectal cancer
E Lakatos, V Gunasri, L Zapata, J Househam, T Heide, N Trahearn, ...
Annals of Oncology 35, S68, 2024
2024
416P Evolutionary and immune microenvironment dynamics determine response to neoadjuvant treatment of oesophageal adenocarcinoma
M Barroux, J Househam, E Lakatos, T Ronel, AM Baker, H Salié, ...
Annals of Oncology 35, S168-S169, 2024
2024
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Artikler 1–20