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Srinivasa R. Penumutchu
Srinivasa R. Penumutchu
Senior Research Associate, HHMI
Verifisert e-postadresse på pennmedicine.upenn.edu - Startside
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IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
J Davila-Calderon, NN Patwardhan, LY Chiu, A Sugarman, Z Cai, ...
Nature communications 11 (1), 4775, 2020
922020
Structural insights into calcium-bound S100P and the V domain of the RAGE complex
SR Penumutchu, RH Chou, C Yu
PloS one 9 (8), e103947, 2014
612014
Genome-wide analysis of heterogeneous nuclear ribonucleoprotein (hnRNP) binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing
SB Kutluay, A Emery, SR Penumutchu, D Townsend, K Tenneti, ...
Journal of virology 93 (21), 10.1128/jvi. 01048-19, 2019
362019
Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions
CCL Yifan Dai a b 1 , Liang-Yuan Chiu c 1 , Yongkun Sui d , Quanbin Dai e ...
Talanta 195, Pages 46-54, 2019
232019
Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H
SR Penumutchu, LY Chiu, JL Meagher, AL Hansen, JA Stuckey, ...
Journal of the American Chemical Society 140 (37), 11661-11673, 2018
162018
Interaction between S100P and the anti-allergy drug cromolyn
SR Penumutchu, RH Chou, C Yu
Biochemical and biophysical research communications 454 (3), 404-409, 2014
152014
A structurally conserved RNA element within SARS-CoV-2 ORF1a RNA and S mRNA regulates translation in response to viral S protein-induced signaling in human lung cells
A Basu, S Penumutchu, K Nguyen, U Mbonye, BS Tolbert, J Karn, ...
Journal of Virology 96 (2), e01678-21, 2022
102022
Phosphomimetic substitutions in TDP-43’s transiently α-helical region suppress phase separation
R Haider, S Penumutchu, S Boyko, WK Surewicz
Biophysical Journal 123 (3), 361-373, 2024
92024
Thermodynamic Coupling of the tandem RRM domains of hnRNP A1 underlie its Pleiotropic RNA Binding Functions
JD Levengood, D Potoyan, S Penumutchu, A Kumar, Y Wang, AL Hansen, ...
Sci. Adv.10, eadk 6580(2024), 2024
62024
Enterovirus evolution reveals the mechanism of an RNA-targeted antiviral and determinants of viral replication
J Davila-Calderon, ML Li, SR Penumutchu, C Haddad, L Malcolm, J King, ...
Science Advances 10 (7), eadg3060, 2024
52024
Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid neoplasms
BA Wang, HM Mehta, SR Penumutchu, BS Tolbert, C Cheng, M Kimmel, ...
Leukemia 36 (10), 2499-2508, 2022
52022
Design, synthesis, molecular docking and cytotoxic activity of novel urea derivatives of 2-amino-3-carbomethoxythiophene
KRAUP Venugopalarao Vikram, Srinivasa R Penumutchu, Raviraj Vankayala ...
Journal of Chemical Sciences 132 (126), 2020
42020
1H, 15N and 13C assignments of the calcium bound S100P
SR Penumutchu, SK Mohan, C Yu
Biomolecular NMR assignments 7, 5-8, 2013
42013
The repurposing of cellular proteins during enterovirus A71 infection
SM Abedeera, J Davila-Calderon, C Haddad, B Henry, J King, ...
Viruses 16 (1), 75, 2023
22023
Backbone resonance assignments of the PRYSPRY domain of TRIM25
C Kong, SR Penumutchu, K Hung, H Huang, T Lin, C Yu
Biomolecular NMR assignments 9, 313-315, 2015
22015
Protocol to identify drug-binding sites in proteins using solution NMR spectroscopy
S Penumutchu, J Liu, UK Singh, TG Kutateladze, Y Zhang
STAR protocols 3 (4), 101842, 2022
12022
Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex
J Davila-Calderon, N Patwardhan, LY Chiu, A Sugarman, Z Cai, ...
bioRxiv, 2020.03. 10.981167, 2020
12020
A regulatory interplay: hnRNP A1 and AUF1 compete for the same IRES domain to regulate viral translation in EV71
S Penumutchu, J Calderon, B Tolbert
The FASEB Journal 33, 625.5-625.5, 2019
1*2019
Design, synthesis and biological studies of tetrazole fused imidazopyridines.
MVBR Banoth Reddy, Amit Kumar Taneja, Mandava Bhuvan Tej, Komati Navya Sri ...
Carbon Letters 2024, 34 (1) , 41-49 34 (1), 41-49, 2024
2024
Investigating the Interaction of Enterovirus A71 3C Protease and the 5’-Untranslated Region to Highlight Druggable Surfaces
BST Christina Haddad1 , Srinivasa Penumutchu1
ICMRBS 2022, 2022
2022
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Artikler 1–20