| Moisture stable dialkylimidazolium salts as heterogeneous and homogeneous Lewis acids in the Diels-Alder reaction J Howarth, K Hanlon, D Fayne, P McCormac Tetrahedron letters 38 (17), 3097-3100, 1997 | 355 | 1997 |
| Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries H Veith, N Southall, R Huang, T James, D Fayne, N Artemenko, M Shen, ... Nature biotechnology 27 (11), 1050-1055, 2009 | 214 | 2009 |
| Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer L Mawhinney, ME Armstrong, C O’Reilly, R Bucala, L Leng, ... Molecular Medicine 20, 729-735, 2014 | 87 | 2014 |
| Oncology exploration: charting cancer medicinal chemistry space DG Lloyd, G Golfis, AJS Knox, D Fayne, MJ Meegan, TI Oprea Drug discovery today 11 (3-4), 149-159, 2006 | 67 | 2006 |
| The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin … SM Cloonan, A Drozgowska, D Fayne, DC Williams Leukemia & lymphoma 51 (3), 523-539, 2010 | 60 | 2010 |
| “True” Antiandrogens Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer L Caboni, GK Kinsella, F Blanco, D Fayne, WN Jagoe, M Carr, ... Journal of medicinal chemistry 55 (4), 1635-1644, 2012 | 55 | 2012 |
| Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin AJS Knox, T Price, M Pawlak, G Golfis, CT Flood, D Fayne, DC Williams, ... Journal of medicinal chemistry 52 (8), 2177-2180, 2009 | 49 | 2009 |
| β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells AM Malebari, LM Greene, SM Nathwani, D Fayne, NM O'Boyle, S Wang, ... European journal of medicinal chemistry 130, 261-285, 2017 | 48 | 2017 |
| β-Lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells AM Malebari, D Fayne, SM Nathwani, F O’Connell, S Noorani, B Twamley, ... European journal of medicinal chemistry 189, 112050, 2020 | 42 | 2020 |
| Lead optimization of benzoxepin-type selective estrogen receptor (ER) modulators and downregulators with subtype-specific ERα and ERβ activity NM O’Boyle, I Barrett, LM Greene, M Carr, D Fayne, B Twamley, AJS Knox, ... Journal of medicinal chemistry 61 (2), 514-534, 2018 | 39 | 2018 |
| Novel selective estrogen receptor ligand conjugates incorporating endoxifen-combretastatin and cyclofenil-combretastatin hybrid scaffolds: Synthesis and biochemical evaluation PM Kelly, NO Keely, SA Bright, B Yassin, G Ana, D Fayne, DM Zisterer, ... Molecules 22 (9), 1440, 2017 | 39 | 2017 |
| The vascular targeting agent combretastatin-A4 and a novel cis-restricted β-lactam analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo … LM Greene, SM Nathwani, SA Bright, D Fayne, A Croke, M Gagliardi, ... The Journal of pharmacology and experimental therapeutics 335 (2), 302-313, 2010 | 37 | 2010 |
| Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds DK Nevin, MB Peters, G Carta, D Fayne, DG Lloyd Journal of medicinal chemistry 55 (11), 4978-4989, 2012 | 35 | 2012 |
| Rational targeting of peroxisome proliferating activated receptor subtypes D K. Nevin, D G. Lloyd, D Fayne Current medicinal chemistry 18 (36), 5598-5623, 2011 | 32 | 2011 |
| Novel microtubule-targeting agents, pyrrolo-1, 5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells SM Nathwani, S Butler, D Fayne, NN McGovern, B Sarkadi, MJ Meegan, ... Cancer chemotherapy and pharmacology 66, 585-596, 2010 | 31 | 2010 |
| Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles PM Kelly, SA Bright, D Fayne, JK Pollock, DM Zisterer, DC Williams, ... Bioorganic & Medicinal Chemistry 24 (18), 4075-4099, 2016 | 26 | 2016 |
| Modelling metal complexes of calixarene esters and phosphine oxides using molecular mechanics P Kane, K Kincaid, D Fayne, D Diamond, MA McKervey Molecular modeling annual 6, 272-281, 2000 | 24 | 2000 |
| Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators V Onnis, GK Kinsella, G Carta, WN Jagoe, T Price, DC Williams, D Fayne, ... Journal of medicinal chemistry 53 (8), 3065-3074, 2010 | 23 | 2010 |
| Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire AJ Kesel, Z Huang, MG Murray, MN Prichard, L Caboni, DK Nevin, ... Antiviral Chemistry and Chemotherapy 23 (5), 197-215, 2014 | 22 | 2014 |
| Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design PB McKay, MB Peters, G Carta, CT Flood, E Dempsey, A Bell, C Berry, ... Bioorganic & medicinal chemistry letters 21 (11), 3335-3341, 2011 | 22 | 2011 |