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Bruno Guigas
Bruno Guigas
Associate Professor - Leiden University Medical Center
Verifisert e-postadresse på lumc.nl - Startside
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Cellular and molecular mechanisms of metformin: an overview
B Viollet, B Guigas, NS Garcia, J Leclerc, M Foretz, F Andreelli
Clinical science 122 (6), 253-270, 2012
22402012
Metformin: from mechanisms of action to therapies
M Foretz, B Guigas, L Bertrand, M Pollak, B Viollet
Cell metabolism 20 (6), 953-966, 2014
15282014
Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
B Viollet, M Foretz, B Guigas, S Horman, R Dentin, L Bertrand, L Hue, ...
The Journal of physiology 574 (1), 41-53, 2006
6552006
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
M Foretz, B Guigas, B Viollet
Nature Reviews Endocrinology 15 (10), 569-589, 2019
5992019
AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
B Viollet, B Guigas, J Leclerc, S Hébrard, L Lantier, R Mounier, F Andreelli, ...
Acta physiologica 196 (1), 81-98, 2009
5862009
AMPK: Lessons from transgenic and knockout animals
B Viollet, Y Athea, R Mounier, B Guigas, E Zarrinpashneh, S Horman, ...
Frontiers in bioscience (Landmark edition) 14, 19, 2009
3742009
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin
C Batandier, B Guigas, D Detaille, M El-Mir, E Fontaine, M Rigoulet, ...
Journal of bioenergetics and biomembranes 38, 33-42, 2006
3702006
Metformin: update on mechanisms of action and repurposing potential
M Foretz, B Guigas, B Viollet
Nature Reviews Endocrinology 19 (8), 460-476, 2023
3512023
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
X Stephenne, M Foretz, N Taleux, GC Van Der Zon, E Sokal, L Hue, ...
Diabetologia 54, 3101-3110, 2011
3492011
Metformin prevents high-glucose–induced endothelial cell death through a mitochondrial permeability transition-dependent process
D Detaille, B Guigas, C Chauvin, C Batandier, E Fontaine, ...
Diabetes 54 (7), 2179-2187, 2005
3392005
Role of mitochondria in the mechanism (s) of action of metformin
G Vial, D Detaille, B Guigas
Frontiers in endocrinology 10, 294, 2019
2992019
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons
MY El-Mir, D Detaille, G R-Villanueva, M Delgado-Esteban, B Guigas, ...
Journal of Molecular Neuroscience 34, 77-87, 2008
2972008
Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice
L Hussaarts, N García‐Tardón, L van Beek, MM Heemskerk, S Haeberlein, ...
The FASEB Journal, 3027-3039, 2015
2292015
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase–independent effect on glucokinase …
B Guigas, L Bertrand, N Taleux, M Foretz, N Wiernsperger, D Vertommen, ...
Diabetes 55 (4), 865-874, 2006
2202006
Role of AMP kinase and PPARδ in the regulation of lipid and glucose metabolism in human skeletal muscle
DK Krämer, L Al-Khalili, B Guigas, Y Leng, PM Garcia-Roves, A Krook
Journal of Biological Chemistry 282 (27), 19313-19320, 2007
2122007
Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice
JJ Geerling, MR Boon, GC van der Zon, SAA van den Berg, ...
Diabetes 63 (3), 880-891, 2014
2032014
Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study
B Guigas, D Detaille, C Chauvin, C Batandier, F De Oliveira, E Fontaine, ...
Biochemical journal 382 (3), 877-884, 2004
1942004
Mitochondrial metabolism and type-2 diabetes: a specific target of metformin
XM Leverve, B Guigas, D Detaille, C Batandier, EA Koceir, C Chauvin, ...
Diabetes & metabolism 29 (4), 6S88-6S94, 2003
1932003
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
L Bertrand, A Ginion, C Beauloye, AD Hebert, B Guigas, L Hue, ...
American Journal of Physiology-Heart and Circulatory Physiology 291 (1 …, 2006
1852006
Interleukin-33-activated islet-resident innate lymphoid cells promote insulin secretion through myeloid cell retinoic acid production
E Dalmas, FM Lehmann, E Dror, S Wueest, C Thienel, M Borsigova, ...
Immunity 47 (5), 928-942. e7, 2017
1592017
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