Molecular safeguarding of CRISPR gene drive experiments J Champer, J Chung, YL Lee, C Liu, E Yang, Z Wen, AG Clark, ... Elife 8, e41439, 2019 | 118 | 2019 |
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs SE Champer, SY Oh, C Liu, Z Wen, AG Clark, PW Messer, J Champer Science Advances 6 (10), eaaz0525, 2020 | 105 | 2020 |
CRISPR gene drive efficiency and resistance rate is highly heritable with no common genetic loci of large effect J Champer, Z Wen, A Luthra, R Reeves, J Chung, C Liu, YL Lee, J Liu, ... Genetics 212 (1), 333-341, 2019 | 46* | 2019 |
Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain A Bhattacharya, DD Vo, C Jops, M Kim, C Wen, JL Hervoso, B Pasaniuc, ... Nature genetics 55 (12), 2117-2128, 2023 | 37* | 2023 |
Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain C Wen, M Margolis, R Dai, P Zhang, PF Przytycki, DD Vo, A Bhattacharya, ... Science 384 (6698), eadh0829, 2024 | 26 | 2024 |
Brain cell-type shifts in Alzheimer’s disease, autism, and schizophrenia interrogated using methylomics and genetics CX Yap, DD Vo, MG Heffel, A Bhattacharya, C Wen, Y Yang, KE Kemper, ... Science Advances 10 (21), eadn7655, 2024 | 7 | 2024 |
Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements HE Pratt, G Andrews, N Shedd, N Phalke, T Li, A Pampari, M Jensen, ... Science Advances 10 (21), eadj4452, 2024 | 5 | 2024 |
Multivariate variance components analysis uncovers genetic architecture of brain isoform expression and novel psychiatric disease mechanisms M Kim, DD Vo, CT Jops, C Wen, A Patowary, A Bhattacharya, CX Yap, ... medRxiv, 2022.10. 18.22281204, 2022 | 3 | 2022 |
Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis N Aygün, C Vuong, O Krupa, J Mory, BD Le, JM Valone, D Liang, B Shafie, ... The American Journal of Human Genetics 111 (9), 1877-1898, 2024 | | 2024 |
Trans-Ancestry Analysis of Psychosis Biotypes: Shared Polygenic Risk and Unique Genomic Associations E Gershon, C Xia, N Alliey-Rodriguez, C Tamminga, M Keshavan, ... | | 2024 |